DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and Ptpn18

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_035336.2	Gene:	Ptpn18 / 19253	MGIID:	108410	Length:	453	Species:	Mus musculus

Alignment Length:	274	Identity:	97/274 - (35%)
Similarity:	146/274 - (53%)	Gaps:	18/274 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   673 NKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMI 737
            |..||||.::.|||.:||.|.... ::.:.||||||||.|.....|:|.||||||.|...|||::
Mouse    56 NTNKNRYKDVVAYDETRVILSLLQ-EEGHGDYINANFIRGIDGSQAYIATQGPLPHTLLDFWRLV 119

  Fly   738 WEQRVAIIVMITNLVERGRRKCDMYWPKDGVE-TYGVIQVKLIEEEVMST-YTVRTLQIKHLKLK 800
            ||..|.:|:|.....|.|||||:.||.::... ..|...:.|.:|..::. .|:||||:...|
Mouse   120 WEFGVKVILMACQETENGRRKCERYWAREQEPLKAGPFCITLTKETTLNADITLRTLQVTFQK-- 182

  Fly   801 KKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIV 865
                  ..:.|:|..|.:|||||.|.....:|..|:::........||:.||||||.||||....
Mouse   183 ------EFRSVHQLQYMSWPDHGVPSSSDHILTMVEEARCLQGLGPGPLCVHCSAGCGRTGVLCA 241

  Fly   866 LDAMLKQIQQKNI---VNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIAS--GETNLMAEQV 925
            :|.:.:.:..:.|   .::|..:..:|.||...|||||||.||:..:.:..:.  .:|:...:.:
Mouse   242 VDYVRQLLLTQTIPPNFSLFQVVLEMRKQRPAAVQTEEQYRFLYHTVAQLFSRTLQDTSPHYQNL 306

  Fly   926 EELKNCTPYLEQQY 939
            :|  ||.|..::.:
Mouse   307 KE--NCAPICKEAF 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	92/242 (38%)
		PTPc	676..911	CDD:238006	91/239 (38%)
		PTPc	935..1186	CDD:214550	0/5 (0%)
		PTPc	963..1169	CDD:238006
Ptpn18	NP_035336.2	Y_phosphatase	56..290	CDD:278528	92/242 (38%)
		PTPc	59..290	CDD:238006	91/239 (38%)
		Substrate binding. /evidence=ECO:0000250	229..235		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	384..453
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810