DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and Ptpn1

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_035331.3	Gene:	Ptpn1 / 19246	MGIID:	97805	Length:	432	Species:	Mus musculus

Alignment Length:	494	Identity:	139/494 - (28%)
Similarity:	222/494 - (44%)	Gaps:	132/494 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   651 YEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQK 715
            |:.|::|  :.|.||:.::.|:||.:|||.:::.:||||:.||    |:.| |||||:.|...:.
Mouse    20 YQDIRHE--ASDFPCKVAKLPKNKNRNRYRDVSPFDHSRIKLH----QEDN-DYINASLIKMEEA 77

  Fly   716 GHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWP----KDGVETYGVIQV 776
            ..::|.||||||:|...||.|:|||:...:||:..::|:|..||..|||    |:.|.....:::
Mouse    78 QRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRIMEKGSLKCAQYWPQQEEKEMVFDDTGLKL 142

  Fly   777 KLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKK--SS 839
            .||.|:|.|.||||.|::::|..|:.::      :..:|||.|||.|.|:.|...|||:.|  .|
Mouse   143 TLISEDVKSYYTVRQLELENLTTKETRE------ILHFHYTTWPDFGVPESPASFLNFLFKVRES 201

  Fly   840 AANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQK---NIVNVFGFLRHIRAQRNFLVQTEEQ 901
            .:...|.||||||||||:||:||:.:.|..|..:.::   :.|::...|..:|..|..|:||.:|
Mouse   202 GSLSLEHGPIVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRRFRMGLIQTADQ 266

  Fly   902 YIFLHDALVEAIASGETNLMAEQVEELKNCTPYLEQQYKNIIQFQPKDIHIASAMKQVNSIKNRG 966
            ..|.:.|::|    |...:|.:.         .::.|:|.:.:   :|:.:
Mouse   267 LRFSYLAVIE----GAKFIMGDS---------SVQDQWKELSR---EDLDL-------------- 301

  Fly   967 AIFPIEGSRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVV 1031
               |.|    |:.|.|                          .|...|::       .||.:...
Mouse   302 ---PPE----HVPPPP--------------------------RPPKRTLE-------PHNGKCKE 326

  Fly  1032 LLSSLDDINFAQFWPDEATPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKML----- 1091
            |.||       ..|..|.|..:.|.     |.:.......|....:.|:..|.|:..:|:
Mouse   327 LFSS-------HQWVSEETCGDEDS-----LAREEGRAQSSAMHSVSSMSPDTEVRRRMVGGGLQ 379

  Fly  1092 ------------------HCPSWPEMSNPNSIYDFIVDV 1112
                              |...||....|     |:|:|
Mouse   380 SAQASVPTEEELSSTEEEHKAHWPSHWKP-----FLVNV 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	104/268 (39%)
		PTPc	676..911	CDD:238006	95/243 (39%)
		PTPc	935..1186	CDD:214550	32/201 (16%)
		PTPc	963..1169	CDD:238006	29/173 (17%)
Ptpn1	NP_035331.3	PTPc	3..276	CDD:214550	104/268 (39%)
		PTPc	43..276	CDD:238006	95/243 (39%)
		Substrate binding. /evidence=ECO:0000250	215..221		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..322		9/78 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..399		9/68 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810