DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and ZK484.7

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_491758.1	Gene:	ZK484.7 / 191327	WormBaseID:	WBGene00022753	Length:	344	Species:	Caenorhabditis elegans

Alignment Length:	349	Identity:	100/349 - (28%)
Similarity:	158/349 - (45%)	Gaps:	61/349 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   631 EFAKHVASLHADGDIGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPT 695
            :..|.|.:....|..|...|:.|::.  .:|....:..:..:...||||.::...||:||.|||
Worm    39 QIVKFVKNALEKGPAGLRAEFAAMKR--FNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHP- 100

  Fly   696 PGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRK-C 759
            |...   |||:|||:........||.||.||..:...||.|..:::|..|.|:.|::|:|.:| |
Worm   101 PWPH---DYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCC 162

  Fly   760 DMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVY------------ 812
            |.:..||        :..|..||......|:......:|.:|.......:.|:
Worm   163 DYFACKD--------KPVLEFEEKGHKIIVKFESTGKMKFEKNTDAKITETVFTVEGPGGLAQKV 219

  Fly   813 -QYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQI--- 873
             |||:.:|||.|.|...:.::..:.|:   .|:: ||.|||||||:||||:.::::.:|.|:
Worm   220 TQYHWIDWPDRGVPTADMAIVELLAKT---RPSK-GPTVVHCSAGIGRTGSVVMIEYILDQLLGG 280

  Fly   874 QQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELKNCTPYLEQQ 938
            ||  |......|:.||.|||..:||::||:|:|..:                  |..|..
Worm   281 QQ--IEETDKILQKIREQRNNSIQTDQQYLFVHQVI------------------LNYCLD----- 320

  Fly   939 YKNIIQFQPKDIHIASAMKQVNSI 962
             |.:.....|..|:|...|.:.|:
Worm   321 -KKMFDVDVKLAHLAFTEKYMKSV 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	89/281 (32%)
		PTPc	676..911	CDD:238006	85/251 (34%)
		PTPc	935..1186	CDD:214550	6/28 (21%)
		PTPc	963..1169	CDD:238006	100/349 (29%)
ZK484.7	NP_491758.1	Y_phosphatase	80..316	CDD:278528	85/271 (31%)
ZK484.7	NP_491758.1	PTPc	81..316	CDD:238006	85/270 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810