DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and ptp-5.2

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_502779.1	Gene:	ptp-5.2 / 190372	WormBaseID:	WBGene00013304	Length:	482	Species:	Caenorhabditis elegans

Alignment Length:	414	Identity:	88/414 - (21%)
Similarity:	157/414 - (37%)	Gaps:	113/414 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   600 DDPP--------------------HHPNAPQVDWEVPVKIGDEIR------AAVPVNEFAKHVAS 638
            ||||                    ...||.|...|| |..|.:.:      .|.||:.  |...:
Worm   100 DDPPLPIATSVAGTVTTTGMPALLPAENATQPLKEV-VNSGKKSKGAPNSATATPVSH--KSTIT 161

  Fly   639 LHADGDIG---------------FSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHS 688
            ..||..:|               ..:|:|.:|:..:..:..|:  ....|.:.|:..:..|.|.:
Worm   162 EGADKWVGEDVAKNWMDSIDLAEVKKEFEKLQSMKVDVEKECK--TWKANSKYNQSEDFPALDSN 224

  Fly   689 RVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVE 753
            .:        |...||:|.:.::.....:.:|| |.|:.||.:.||:.::::|:..|.:|.
Worm   225 LL--------KVEKDYVNISRVEIPLGRNIYIG-QVPVKDTEETFWKAVFDKRIVSIDVIV---- 276

  Fly   754 RGRRKCDMYWPK--DGVETYGVIQVKLIEEEVMSTYTVR-TLQIKHLKLKKKKQCNTEKLVYQYH 815
             |....: ::||  :..:.||.:.:...:.|.:|....| ::::..........||...:
Worm   277 -GDEPIE-FFPKKAEDYKNYGQMWINNRKVEYVSDDVFRFSIEVLPHGCSNSIICNVTVI----- 334

  Fly   816 YTNWPDHGTPDHPLPVLNFVKKSSAAN------------PAEAGPIVVHCSAGVGRTGTYIVLDA 868
             :||.....|         ||::.|..            ||:.. .:::...|.||.|.::.|..
Worm   335 -SNWKVDSVP---------VKQAIAIKEAFGLNSYLLKAPADDN-AMINSQHGAGRAGYFLALAV 388

  Fly   869 MLKQIQQK----NIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELK 929
            .:..|..|    .||::   ::.||:||...|.:..||..|:.:|:..|....|    :..|..|
Worm   389 AVHTIDTKVAEPCIVDI---VKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKVT----KPAEGDK 446

  Fly   930 NCTP---YLE-------QQYKNII 943
            ..||   ||.       :|:.||:
Worm   447 KSTPTNKYLHKKSVEMTKQFTNIL 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	60/298 (20%)
		PTPc	676..911	CDD:238006	54/253 (21%)
		PTPc	935..1186	CDD:214550	4/16 (25%)
		PTPc	963..1169	CDD:238006
ptp-5.2	NP_502779.1	PTPc	185..432	CDD:214550	59/282 (21%)
ptp-5.2	NP_502779.1	PTPc_motif	336..432	CDD:214649	26/108 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810