DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and W01B6.6

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_501827.3	Gene:	W01B6.6 / 189083	WormBaseID:	WBGene00012173	Length:	366	Species:	Caenorhabditis elegans

Alignment Length:	328	Identity:	74/328 - (22%)
Similarity:	132/328 - (40%)	Gaps:	50/328 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   630 NEFAKHVASLHADGDIGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHP 694
            :|.||.:.:..|......:..::.:.|...|.|: |  |....|.:|:|..:....|:..:.|..
Worm    76 DETAKKLVASGAFNTSTITSGFKELSNPKPSADM-C--SIFKNNPKKSRAPDWPIADNKLIKLSH 137

  Fly   695 TPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPD-----TFDCFWRMIWEQRVAIIVMITNLVER 754
            .||     ::|.|..:|..:.....|.||  :||     ..:.|||||:::.:..||:....:|.
Worm   138 APG-----NFICAAKVDVPEFNRTMIVTQ--IPDVTVSANIEDFWRMIFQEEIVSIVIAVMPLEC 195

  Fly   755 GRRKCDMYWPKDGV-ETYG--VIQVKLIEEEV-MSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYH 815
            ......::....|. ..:|  .:..|.::..| |:.||:..|         ...|:...|...||
Worm   196 SVTLQQLFPLLSGTFSNHGKMFLNNKKVDSAVAMTAYTLEVL---------PDGCSNSLLSTVYH 251

  Fly   816 YTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVN 880
            ..||......::...::..|:|....|.    ..|:....|:||.||.:.|...:..:|:...||
Worm   252 LHNWKQKQGLENVGELVTTVEKVLKTNE----NTVLMSMNGIGRAGTMLTLFTSMLSVQKSKEVN 312

  Fly   881 VFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELKN-CTPYLEQQYKNIIQ 944
            ....|..:|.:|:.||:..:|:..:|.|:               ....|| |:.  |:..|.:::
Worm   313 PKEILIKLRGERSGLVENADQFNTVHRAM---------------ALWFKNKCSD--EEVQKKVVE 360

  Fly   945 FQP 947
            |.|
Worm   361 FAP 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	63/273 (23%)
		PTPc	676..911	CDD:238006	57/243 (23%)
		PTPc	935..1186	CDD:214550	4/13 (31%)
		PTPc	963..1169	CDD:238006
W01B6.6	NP_501827.3	PTPc	97..342	CDD:214550	63/282 (22%)
W01B6.6	NP_501827.3	PTPc	118..342	CDD:304379	57/258 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810