Protein Alignment Ptp99A and R155.3

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_497485.1
• Gene: R155.3 / 187909
• WormBaseID: WBGene00020117
• Length: 1165
• Species: Caenorhabditis elegans
• Alignment Length: 1115
• Identity: 209/1115 - (18%)
• Similarity: 392/1115 - (35%)
• Gaps: 295/1115 - (26%)

  Fly    35 GRIFDVTNLDYVKVNAEAGKNVTIPCPG-------------------VNEHS--LVDTL----VW 74
            |.::::....:::|::.|.|:|:....|                   |.:||  |.:.|    .:
 Worm   142 GTLYELLKSRHLRVSSVALKHVSGFLNGHSDILHLFKDLEDKWIKDAVRDHSGNLANALNQLKTF 206

  Fly    75 KTASTTIAQ-FANRIPLLHS--------PRIQLLSDNFGLQFSPSLASDTSEYICLVNDRHIPEA 130
            :.::..:.| |.:...:|..        |:...|:|...     :|.|...|.:...:.: :|.:
 Worm   207 EASTRKVHQSFVSEAVMLEEVSKIRSKIPKYSGLADKIA-----TLPSKIHEILGTPSVK-LPTS 265

  Fly   131 IVDLLVQDVPDPPERPLLISFTSRSVNLSWAHSQHPRNAPVTHFIIE--TREGEDGIWEQLARIY 193
            ..|.:.:.:|...:.|..:....:.:|.| ...:.|.||.....|||  .::|::.:...|....
 Worm   266 DKDKVDKAIPLMAQLPAQLKALEKLMNFS-EQLKLPENAKKLGNIIEIVNQDGKNQLENTLKMFK 329

  Fly   194 TKTNATSYQVTGLTPFTVYSFRLLAVNKLGISPPSKESYYIVTLREAPTGKPIPTTAHNTSSTSV 258
            :.|:...          :|:..|          |.|::.      |.....||..||.|..|:.
 Worm   330 SSTDVKE----------IYTLLL----------PVKDTL------ELLKDNPIHETAANIISSL- 367

  Fly   259 YISWKAPPPDTILGEFLGYRITYRPRDRDPNDTKEIYIRDNTVESHE-----IQNLQTYTQYKVT 318
                     |.:              ::...|..:.:...|::...|     |..:.|..|.:::
 Worm   368 ---------DKV--------------EKFAQDMADFFTALNSIRQIEESSLIIPVITTIRQLRLS 409

  Fly   319 VQVFNPEGLGPETTILVMTDEGVPSKPQNLTILDVSANSITMSWHPPKNQNGAIAGYHVFHIHDN 383
            ...|   ||   ||:|    ..:|.....|:.|....||:..:.|.   :..|:..:....:|..
 Worm   410 NDQF---GL---TTVL----NNLPMIKTQLSSLTSYINSVKKTKHA---ETDALKDFEKIGLHSR 461

  Fly   384 QTGV---------------------EIVKNSRNSVETLIHFE-LQNLR--------------PYT 412
            ..|.                     ::||:....|:..::.| :.||:              ...
 Worm   462 VIGTATRGISNMQKLVDFKDLADIGDLVKSEVEKVKDQLNDENVANLKALAGIEGQLKTASGEIV 526

  Fly   413 DYRVIVKAFTTKNEGEPSDQIAQRTDVGGPS--APAIVNLTCHSQESITIRWRRPYEFYNTIDFY 475
            .|:..||..|:.:..:.|........|.|.:  .|||::........:.||..|.......:|.|
 Worm   527 GYKKSVKPVTSTSLPDYSTFFLDAKKVKGINLKLPAIISSMEKLNNLVPIRSSRATRSSTQLDGY 591

  Fly   476 IIKTR------LAGQDTHRDIRINASAKELETAMILQNLTTNSYYEVKVAAATFSVINPKKIVLG 534
            ::..:      |.....|:.  .:.|.:.|:...:......|:..:.|.|||.      :|...|
 Worm   592 LLSLQSLSSISLDFTKFHKS--FDGSTQSLQDLGVSFAKYNNTLTKQKAAAAA------QKSGGG 648

  Fly   535 KFSESRIIQ--LQPNCEKLQPLLRQSHNDYNLAVLVGIIFSCFGIILIIMA-----FFLW----- 587
            ..|.|...|  .:.|                 :.:|.|:|.|...|.:|:.     |:|.
 Worm   649 SSSASGGSQGVFESN-----------------STIVLIVFGCIVFICVILIPASSWFYLHQKDPA 696

  Fly   588 SRKCFHAAYYYLDDPPHHPNAPQVDWEVPVKIGD--------EIRAAVPVNEFAKHVASLHADGD 644
            :||||...           ..|..:.:.|||..|        |.......:|..|.|..|..:.|
 Worm   697 ARKCFAIR-----------ELPMEEVKKPVKKKDVSKMDNKPERELEKTQDESIKDVPKLILELD 750

  Fly   645 IGFSRE-----YEAIQN----ECI---SDDL------------------PCEHSQHPENKRKNRY 679
            :..:.:     |||:|:    .||   |::|                  |...:...|..::.
 Worm   751 MSSAEKYVDCRYEALQDMHKETCIPFLSEELIKKFYGVKFDAMNEKYEVPGREALKSEQMKQR-- 813

  Fly   680 LNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQGP-------LPDTFDCFWRMI 737
            |.|.....:||.|... |...|.|||:||.:. ...|...|.:|.|       ...|.:.:|...
 Worm   814 LPIPLVMDTRVVLKDY-GTLFNDDYIHANRVT-CSHGLQLILSQAPQEANGESCESTIESYWWTA 876

  Fly   738 WEQRVAIIVMITNLVER--GR-RKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKL 799
            .:::...:||:.:..|:  |: ..|..|:|:...|:   ::.|.:..|..|....:..:.:.|::
 Worm   877 KQEKSTQLVMMCDFDEKCPGKTNSCARYYPESVGES---MKFKNLTVECKSKIAEKDFETRELEV 938

  Fly   800 K----KKKQCNTEKLVYQYHYTNW-PDHGTPDHPL--PVLNFVKKSSAANPAEAGPIVVHCSAGV 857
            |    :.......:||      .| |.:..||..|  .::..:|.|:.       |::|||..|:
 Worm   939 KFDGHEPHTVTHSRLV------GWNPLNVQPDTLLFTSLIQKIKNSTT-------PVMVHCIDGI 990

  Fly   858 GRTGTY--IVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIA------ 914
            .|:..:  :::...| .||....|.:...:.:||:||...:.:..:..|:...:|:.:.
 Worm   991 SRSAAFASMIIGYQL-VIQSLGSVKLEAVVSYIRSQRAMAITSALELAFVDAGIVKLLGLFVDAQ 1054

  Fly   915 --SGETN----LMAEQVEELKNCTPYLE-QQYKNIIQFQPKDIHIASAMKQVNSIKNRGAIFPIE 972
              .||..    ::|:| |.::..|...| |::.:..|.|..........|::..:|:.|.....|
 Worm  1055 QNKGELTREQCILAQQ-ELMRFYTSCPEAQKWFSWPQKQQAKTGEKRTYKKIKQLKDYGFEVAPE 1118

  Fly   973 GSRVHLTPKP 982
            .....:.|:|
 Worm  1119 PKPTPIAPEP 1128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	17/97 (18%)
		FN3	243..337	CDD:238020	19/98 (19%)
		fn3	343..430	CDD:394996	18/122 (15%)
		FN3	442..520	CDD:238020	14/85 (16%)
		R5-PTPc-1	704..907	CDD:350397	47/221 (21%)
		R5-PTP-2	989..1182	CDD:350398
R155.3	NP_497485.1	PTPc	802..1045	CDD:214550	56/263 (21%)