DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and sre-45

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_496843.2	Gene:	sre-45 / 186258	WormBaseID:	WBGene00010071	Length:	369	Species:	Caenorhabditis elegans

Alignment Length:	196	Identity:	37/196 - (18%)
Similarity:	69/196 - (35%)	Gaps:	59/196 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   857 VGRTGTYIVLDAM-----------LKQIQQKNIV--NVFGFLRHIRAQRNFLV------------ 896
            ||:|.|.:|:..:           ...|...||:  .:|.:::|:..|.|..:
Worm   176 VGQTSTNLVMGYLFFFNAAHFAVGFSIILSTNIIAMGIFTYVKHVNRQVNRAIEDFSNPSLYCLP 240

  Fly   897 ---QTEE-----QYI--FLHDALVEAIASGETNLMAEQVEELKNCTPYLEQQYKNIIQFQPKDIH 951
               |..|     |.|  .:|..|...:.:...||.. .:|......|.|...:::.|...|..|
Worm   241 ARFQVRENVRCFQMITKVIHAGLFLILTACFVNLFM-YLELTPGLDPLLNLIFESAINLNPVVI- 303

  Fly   952 IASAMKQVNSIKN---------------RGAIFPI-------EGSRVHLTPKPGEDGSDYINASW 994
            :.:.:..||:.:|               |..|..:       :|::...|.|..:...|.:|::|
Worm   304 VPTLLGSVNAWRNFTFSSGVCLGFKAQVRLKIIKVSSVSIGNDGAKSDRTRKETDAYFDQLNSAW 368

  Fly   995 L 995
            :
Worm   369 I 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	18/88 (20%)
		PTPc	676..911	CDD:238006	18/88 (20%)
		PTPc	935..1186	CDD:214550	15/83 (18%)
		PTPc	963..1169	CDD:238006	9/55 (16%)
sre-45	NP_496843.2	Sre	1..369	CDD:251743	36/194 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900