DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and F36H12.10

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_500756.1	Gene:	F36H12.10 / 185396	WormBaseID:	WBGene00018124	Length:	398	Species:	Caenorhabditis elegans

Alignment Length:	277	Identity:	86/277 - (31%)
Similarity:	130/277 - (46%)	Gaps:	64/277 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   676 KNRYLNITAYDHSRVHL-HPTPGQKKNLDYINANFIDGYQKG------HAFIGTQGPLPDTFDCF 733
            ||||.::...|.|.|.| .|:|     .:||:||::     |      ..||..||||..|.|.|
Worm   134 KNRYQDVPCQDLSAVKLDQPSP-----CNYIHANYV-----GCPMIPEKRFICAQGPLDQTIDEF 188

  Fly   734 WRMIWEQRVAIIVMITNLVERGRRKCDMYWP---------KDGVETYGVIQVKLIEEEVMSTYTV 789
            |.|:.:.:|..|||:...||.|:.||..|||         |.|.....|...|.:|.:.....|:
Worm   189 WWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVENVSGSKPMERDPEIQITM 253

  Fly   790 --------RTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEA 846
                    :|:.::||:                 :|.|||.|.|...|..|..:   ||...::.
Worm   254 LNLTYSGGQTMSVRHLQ-----------------WTEWPDRGVPPCKLTSLELL---SAIRGSKV 298

  Fly   847 GPIVVHCSAGVGRTGTYIVLDAMLKQI-QQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALV 910
             |||||||||:|||||.:.::.:|::| :.|....:...::.:|.||.|.:|.:.||:|:|..::
Worm   299 -PIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVML 362

  Fly   911 EAIASGETNLMAEQVEE 927
                    |...|:.:|
Worm   363 --------NYFLEKYKE 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	83/259 (32%)
		PTPc	676..911	CDD:238006	83/259 (32%)
		PTPc	935..1186	CDD:214550
		PTPc	963..1169	CDD:238006
F36H12.10	NP_500756.1	PTPc	101..363	CDD:214550	83/267 (31%)
F36H12.10	NP_500756.1	PTPc	133..363	CDD:238006	83/267 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810