DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and F36H1.3

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_502058.3	Gene:	F36H1.3 / 185379	WormBaseID:	WBGene00009492	Length:	532	Species:	Caenorhabditis elegans

Alignment Length:	391	Identity:	119/391 - (30%)
Similarity:	178/391 - (45%)	Gaps:	49/391 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   605 HPNAPQVDWEVPVKIGDEIRAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDLPC---E 666
            ||:|..             |.:|....|.....::.:.|..|.::||    .|.:...||.   |
Worm    94 HPDALN-------------RHSVQTEAFETFTTTVTSMGVDGLAKEY----LETLVPFLPVGYFE 141

  Fly   667 HSQHPENK--RKNRYLNITAYDHSRVHLHP-TPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPD 728
            .|...:|.  :||||.::...|.:||.|.. .||     ||::||::.|.:.  .||.|||||.|
Worm   142 RSIFDKNTEFKKNRYKDVPCNDKTRVILKDGYPG-----DYVHANYVKGTKP--MFILTQGPLKD 199

  Fly   729 TFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWP--KDGVETYGVIQVKLIEEEVMSTYTVRT 791
            |....|||:.::.||.|.|:..|:|.||.||:.|:|  :..|.|:|.|.|...|......:|
Worm   200 TAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQVLTFGEITVTCTESTTPDNHT--- 261

  Fly   792 LQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAG 856
             |:|.|.:..||...:.|| |.|....|||.......|.:|..: :|....|   ||||||||||
Worm   262 -QLKMLTVMDKKSGKSHKL-YHYKIITWPDKSIALSNLAILRTL-RSLRKMP---GPIVVHCSAG 320

  Fly   857 VGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVE---AIASGET 918
            :|||||:..::...:.:...........:|.:|..|...||.:.||:.|.:|:::   |....|.
Worm   321 IGRTGTFAAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDLGVAFKYIED 385

  Fly   919 NLMAEQVEELK-NCTPYLEQQYKNIIQFQ-PKDIHIASAMKQVNSIKNRGAIFPIEGSRVHLTPK 981
            ....:.:|..| |...|:|.....:..|: |..:.|... |:.:..::.||  ....:.||..|.
Worm   386 PKSLDAIETYKRNVADYVEAHPPPLEMFKAPPKVEIEKE-KEKDKDEDDGA--QPSSAPVHTPPA 447

  Fly   982 P 982
            |
Worm   448 P 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	95/272 (35%)
		PTPc	676..911	CDD:238006	86/237 (36%)
		PTPc	935..1186	CDD:214550	11/49 (22%)
		PTPc	963..1169	CDD:238006	6/20 (30%)
F36H1.3	NP_502058.3	PTPc	122..375	CDD:214550	95/272 (35%)
F36H1.3	NP_502058.3	PTPc	152..375	CDD:238006	86/238 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810