DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and C33H5.16

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_501293.3	Gene:	C33H5.16 / 183190	WormBaseID:	WBGene00016382	Length:	341	Species:	Caenorhabditis elegans

Alignment Length:	322	Identity:	98/322 - (30%)
Similarity:	155/322 - (48%)	Gaps:	35/322 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   621 DEIRAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAY 685
            || |..:...:..:.|.:....|.||...|:.|::.  .:|....:..:..::..||||.::...
Worm    26 DE-RQKMQKKQIVQFVQTTLEKGPIGLRNEFNAMKR--FNDFDKMQSFKKAQDHHKNRYKDVGCL 87

  Fly   686 DHSRVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITN 750
            |::||.|...|...   |||:|||:........||..|.||.:|...||.|..::||..|.|:.|
Worm    88 DNNRVKLAHPPWPH---DYIHANFVSTPANAKRFICAQAPLDNTCADFWYMCLQERVEAIFMLCN 149

  Fly   751 LVERGRRKCDMYW-PKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVY-- 812
            |:|:|.:||..|: .|:..|        |:..|.....||:......:|..|..:...::.|.
Worm   150 LMEKGAKKCSEYYATKEKPE--------LVFHEKDQKITVKYEASGTVKFVKPTKAVVKETVLII 206

  Fly   813 -----------QYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVL 866
                       .||:.:|||.|.|...|.::..:.|   |.|.: |||.||||||:||||:.:::
Worm   207 EGPGGQVLKTTHYHWIDWPDRGVPPADLSIIELLIK---ARPLK-GPIAVHCSAGIGRTGSVVMI 267

  Fly   867 DAMLKQIQQKN-IVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEE 927
            :.|.:|:...| |......|:.||.|||..:||:.||:|:|..::....  |..|..|:|::
Worm   268 EYMCEQLLNGNQIEETDKILQKIREQRNNSIQTDHQYLFVHQVMMNFFL--EKKLFDEEVKK 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	88/279 (32%)
		PTPc	676..911	CDD:238006	84/249 (34%)
		PTPc	935..1186	CDD:214550
		PTPc	963..1169	CDD:238006
C33H5.16	NP_501293.3	Y_phosphatase	76..313	CDD:278528	84/251 (33%)
C33H5.16	NP_501293.3	PTPc	77..313	CDD:238006	84/250 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810