DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and B0207.1

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_491722.2	Gene:	B0207.1 / 181834	WormBaseID:	WBGene00015026	Length:	564	Species:	Caenorhabditis elegans

Alignment Length:	324	Identity:	90/324 - (27%)
Similarity:	148/324 - (45%)	Gaps:	51/324 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   629 VNEFAKHVASLHADGDIGFSREYEAIQNECISDDLPCEHSQHP-----ENKRKNRYLNITAYDHS 688
            :|.:.:||.|:   |..|..:||:         |.|...|...     .|..:|||.||...|.:
Worm   258 INAWIRHVLSI---GIEGLKKEYQ---------DSPNGGSIRSAQVFVANPTRNRYTNIPCCDAT 310

  Fly   689 RVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVE 753
            ||.:...|.     .||:||.:.. .|....|..|.||..|.:.|||||....|..|||:..::|
Worm   311 RVKIDDDPD-----FYIHANIVSS-AKYRRIICAQAPLKGTIEEFWRMILSSGVEYIVMLCEIIE 369

  Fly   754 RGRRKCDMYWPKDGVETYGVIQ----VKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQY 814
            .|:.|...|:|....:...:.:    .|:..:::....::..|:|       .::......|...
Worm   370 LGKEKSANYFPSKLGQAMRIGKFCNITKVQHDDIDKVISMSLLRI-------TREGQEPVFVKHV 427

  Fly   815 HYTNWPDHGTPD---HPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQK 876
            |:.||||||.|:   .||.:||..:       :...||::|||||||||||..::...|:.::..
Worm   428 HWHNWPDHGVPESYMSPLHLLNIFR-------SHQKPILIHCSAGVGRTGTLALILIALQTLRSV 485

  Fly   877 NIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELKNCTPYLEQQYK 940
            :...:......:|.:|...:|||.||:|:|..::|.:...:.|:..:      :.|.:| ::||
Worm   486 DFSGIRPLFTRLREERFKAIQTEMQYLFVHRCVLEYLVQKKYNVNRD------DYTKFL-KEYK 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	79/276 (29%)
		PTPc	676..911	CDD:238006	72/241 (30%)
		PTPc	935..1186	CDD:214550	3/6 (50%)
		PTPc	963..1169	CDD:238006
B0207.1	NP_491722.2	PTPc	272..520	CDD:214550	79/276 (29%)
B0207.1	NP_491722.2	PTPc	297..520	CDD:238006	72/242 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810