DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and F38H4.4

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_502243.1	Gene:	F38H4.4 / 178115	WormBaseID:	WBGene00009548	Length:	501	Species:	Caenorhabditis elegans

Alignment Length:	255	Identity:	64/255 - (25%)
Similarity:	115/255 - (45%)	Gaps:	28/255 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   669 QHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCF 733
            |..:|..|||:.::...|||:|||       .:..||:|::::...:..|.: ||.|||.|...|
Worm   221 QFVKNMHKNRFADVICLDHSKVHL-------SDSSYIHASYLELDTQKRAIL-TQLPLPHTSADF 277

  Fly   734 WRMIWEQRVAIIVMITNLVERGRRKCDMYWPKD----GVETYGVIQVKLIEEEVMSTYTVRTLQI 794
            |:||.||||..::::....|......|..:|::    ..|...:...:....|:|..:.::.:.:
Worm   278 WQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDFLNFEERSIRVGEFKRVEIMDGWVLKVVSV 342

  Fly   795 KHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVK-----KSSAANPAEAGPIVVHCS 854
            .:...|        ..::.:||..||.:..|.:..|  .|||     :|.....:.:.|.|....
Worm   343 SNGDYK--------SFLHIHHYNAWPHNNIPGNGSP--KFVKQIWQLQSVLRKYSPSTPTVYMSL 397

  Fly   855 AGVGRTGTYIVLD-AMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAI 913
            :|.||.||:.:.: |.|....::..:::...|..:|..|....|...|:.|::..|.|.|
Worm   398 SGCGRAGTFALFETAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	62/251 (25%)
		PTPc	676..911	CDD:238006	60/244 (25%)
		PTPc	935..1186	CDD:214550
		PTPc	963..1169	CDD:238006
F38H4.4	NP_502243.1	PTPc	214..455	CDD:214550	62/251 (25%)
F38H4.4	NP_502243.1	PTPc	227..455	CDD:238006	60/245 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810