Protein Alignment Ptp99A and ptrg-1

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_001255470.1
• Gene: ptrg-1 / 177898
• WormBaseID: WBGene00010558
• Length: 1159
• Species: Caenorhabditis elegans
• Alignment Length: 1279
• Identity: 347/1279 - (27%)
• Similarity: 571/1279 - (44%)
• Gaps: 238/1279 - (18%)

  Fly    20 FVLLLILATLPATQAGRIFDVTNLDYVKVNAEAGKNVTIPCPG----VNEH--------SLVDTL 72
            |:.|:.|          .:...:.:.:.|.::......:.||.    :..|        .||..|
 Worm     6 FIFLIFL----------FWKFDSAESISVTSKNATEALLRCPPAENFIRTHMAPDFETPRLVRRL 60

  Fly    73 VWKTASTTIAQF-------ANRIPLLHSPRIQLLSDNFGLQFSPSLASDTSEYICLVNDRHI--- 127
            .|....:.:|.:       ::|...:...|.||:...:.|:.||....|:..|.|.:....:
 Worm    61 DWFQDDSLVASYQQDILADSSRQWWVSDGRYQLIRPFYTLRVSPVTPEDSGTYRCRLETDPLFSS 125

  Fly   128 PE--AIVDLLVQDVPDPPERPLLISFTSRSVNLSWAHSQHPRNAPVTHFIIETREGEDGIWEQLA 190
            |:  |..:|.|...|..|..|.:.:||:||:.|.|.|:....:.|:..|.:..|...|.....:|
 Worm   126 PQSTATQELAVMVKPVAPSSPEIKTFTNRSITLVWTHNAARAHRPILRFSVSVRTVSDNTRFVMA 190

  Fly   191 RIYTKTNATSYQVTGLTPFTVYSFRLLAVNKLGISPPSKESYYIVTLREAPTGKPIPTTAHNTSS 255
               ..:|||:..|..|:|:|:|:|.:.|.|..|.|....|:.: .||.|:|...|......|.:|
 Worm   191 ---APSNATTVIVDNLSPYTLYAFSVRAENSAGSSDFGPETTF-RTLGESPNRPPQIQKIRNITS 251

  Fly   256 TSVYISWKAPPPDTILGEFLGYRITYRPRDRDPNDT--KEIYIRDNTVESHEIQNLQTYTQYKVT 318
            ..|.::  ..|||.:.||...|.:..:.    .|:|  :::.....|.....|..|...|.|.:.
 Worm   252 ECVEVT--ITPPDEMNGELDKYLVLIQA----VNETIPRKMTFDKPTSTPLTICALSPSTDYALA 310

  Fly   319 VQVFNPEGLGPETTILVMTDEGVPS-KPQNLTILDVSAN-SITMSW-HPPKNQNGAIAGYHVFH- 379
            ::..|..|..|:.|::..|::.||: .|..:|.|.|... .||:.| .||.|....:..||:::
 Worm   311 IEADNGFGTSPQATLVFHTEDSVPNWSPSTITTLPVVGKPEITVLWPAPPLNATEKVIKYHLYYK 375

  Fly   380 -IHDNQTGVEIVKNSRNSVET-LIHFELQNLRPYTDYRVIVKAFTTKNEG-EPSDQIAQRTDVGG 441
             .:::|..:|.:..|.|.|:: |..:.|.:|.|.|.||:.|.|.|.|.|| :.:|.:|| ||||.
 Worm   376 AKNEDQWKIEHLNVSPNGVKSKLFKYRLVDLNPNTQYRIRVSASTIKGEGAQSADSVAQ-TDVGE 439

  Fly   442 PSAPAIVNLTCHSQESITIRWRRPYE-FYNTIDFYIIKTRLAGQDTHRDIRINASAKELETAMIL 505
            |......:|....:..:.:||.  || ..|:........::..|.|  .::.|.:...|:    :
 Worm   440 PGTVTFKDLNFDCKNGVKLRWN--YEPSVNSKKSPTFTVKVTNQTT--SLQFNTTMLSLD----I 496

  Fly   506 QNLTTNSYYEVKVAAATFSVINPKKIVLGKFSESRIIQLQPNC----------EKLQPLLRQSHN 560
            .:|:....|.:::.....|.|:...|::||:|:|....|:..|          ||...|...:.|
 Worm   497 IDLSLYDEYTLRIIVLERSTIDNSTILIGKYSDSHQFILKDKCSYQSSFCSPGEKCAKLTSSAGN 561

  Fly   561 DYNLAVLVGIIFSCFGIILIIMAFFLWSRKCFHAAYY------------------YLDD--PPHH 605
            ...::||: :||:     :||.||.     ||...::                  ||::  |..:
 Worm   562 PRYISVLI-VIFA-----IIIFAFI-----CFVIVHFARGSMNFKHLLKKKEKCVYLEEISPLVY 615

  Fly   606 PNAPQVDWEVPVKIGDEIRAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECI---SDDLPCEH 667
            .:|.|.|              :||..|..:|..|:.:..:.|..:::.::::..   |.|....:
 Worm   616 DSAGQED--------------IPVELFYGYVEDLNRNDSLKFKTQFQILESQTSGIDSVDSGESN 666

  Fly   668 SQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDC 732
            |...||.:||||.||.|.:.:|:.|:...|.    ||||||::|...:.:|:|.||.|||.||..
 Worm   667 SSSDENSQKNRYNNIGAIEATRIRLNSPTGN----DYINANYVDSCNERNAYIATQAPLPSTFSD 727

  Fly   733 FWRMIWEQRVAIIVMITNLVERGRRKCDMYWP--KDGVETYGVIQVKLIEEEVMSTYTVRTLQIK 795
            ||.|||::|..|||.|||:||.|:||||.|||  :|..:|:|..||.|:.|...:.::.|.|.:|
 Worm   728 FWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSPQTFGNYQVTLVSESTNAHFSHRILDLK 792

  Fly   796 HLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRT 860
            ..|....    .|:.|:|.|:..|||||.|....|:|:||..:|..:  ..||:||||||||||:
 Worm   793 IAKAVPA----VERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDIH--STGPVVVHCSAGVGRS 851

  Fly   861 GTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQV 925
            |:||::|:|.:.:.....:||.|.|.|:|.||..||||.|||||.|:|:.:.|..|.|.:.::..
 Worm   852 GSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITRVHSDLF 916

  Fly   926 --------EELKNCTPYLEQQYKNI--IQFQPKDIHIASAMKQVNSIKNRGAIFPIEGSRVHLTP 980
                    ||..|....::.|:::|  .:.||:.:                    ||
 Worm   917 MRYLHYLSEENLNGKTRMQLQFEDICDCKHQPRCL--------------------IE-------- 953

  Fly   981 KPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDINFAQFW 1045
                  ||.|.   |.|:.|..:|:|..  ..:..:|.|::.|....||:|:|:..|     .||
 Worm   954 ------SDVIT---LPGYHRSDEFMVGS--WGNECEDLWRLTWQQKVQTIVILNQRD-----SFW 1002

  Fly  1046 PDEATPIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKM-------LHCPSWPEMSNPN 1103
            ....:.|.....:::.          ..:||:.. :||.:|.|::       |....|.|:.|
 Worm  1003 RKLPSCIYDGEIQLQH----------GDNFVLLQ-KDDQQLCVRIVNVSRADLDTDFWREIEN-- 1054

  Fly  1104 SIYDFIVDVHERCNDYRNGPIVIV-DRY----------------------GGAQACTFCAISSLA 1145
                    |.::...|.:.|::|: .:|                      ..|.|.:.||.::||
 Worm  1055 --------VQKQRITYHDAPLLILAHKYPPSVPSPTDSTSTLSLSILFNDDTALAFSICAATTLA 1111

  Fly  1146 IEMEYCSTANVYQYAKLYHNKRPGVWTSSEDIRVIYNILSFLPG 1189
            .::|.....:|.|....|...:.|::.|.::|.:||..:|.|.|
 Worm  1112 CQLETTGCVDVVQVLSSYTEIQCGIFASKQEIEIIYEKMSQLVG 1155

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	29/95 (31%)
		FN3	243..337	CDD:238020	21/95 (22%)
		fn3	343..430	CDD:394996	30/93 (32%)
		FN3	442..520	CDD:238020	13/78 (17%)
		R5-PTPc-1	704..907	CDD:350397	97/204 (48%)
		R5-PTP-2	989..1182	CDD:350398	46/222 (21%)
ptrg-1	NP_001255470.1	FN3	40..490	CDD:442628	124/464 (27%)
		FN3	140..232	CDD:238020	29/95 (31%)
		PTPc	642..900	CDD:214550	115/267 (43%)
		PTP_DSP_cys	959..1148	CDD:475123	45/216 (21%)