DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and ptpn-22

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_500128.2	Gene:	ptpn-22 / 176981	WormBaseID:	WBGene00021507	Length:	469	Species:	Caenorhabditis elegans

Alignment Length:	358	Identity:	114/358 - (31%)
Similarity:	182/358 - (50%)	Gaps:	62/358 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   602 PPHHPNAPQVDWEVP--VKIGD-------EIRAAVPVNE-----FAKHVASLHADGDI-GFSREY 651
            ||..|.:..|..:.|  |..||       |.|||..|..     |.|:.|   .||.: .|.:|.
Worm    27 PPPLPTSNPVVKDTPNVVPTGDLIQFESEEERAATTVPNGNPVIFEKNPA---MDGLLREFLKEE 88

  Fly   652 EA--------------IQNECI--SDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKK 700
            ||              ::.|.:  ..:...|.:..|::..:|||.:|..||.:||.:     ||.
Worm    89 EAYTPQDYLRRFYQIRVEQEKLRMEAEYRSECAVAPQHYARNRYRDILPYDKNRVEI-----QKD 148

  Fly   701 NLD---YINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMY 762
            :.:   |:||:.|........||..|.|||.|.|.:|:||.|.||:::|::..|||..:.||:.|
Worm   149 SENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERY 213

  Fly   763 WPKD--GVETYGVIQVKLIEEEVM--STYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHG 823
            ||:.  ..|.:|..::.|.||::.  ..|.:|.|::::   :...:|   :.|:|.||..|||||
Worm   214 WPEQVGESELFGDYEITLEEEKLFDDDEYLMRCLKMEN---QTTGEC---RKVHQLHYREWPDHG 272

  Fly   824 TPDHPLPVLNFV----KKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNI--VNVF 882
            .|.....:||.:    ......:|.::.||:||||||||||||.|.::.:.:|::.:.:  :::|
Worm   273 CPSGEKQLLNMIDLMENIHEEVSPQDSSPILVHCSAGVGRTGTIIAINFIREQMKAETLHSIDIF 337

  Fly   883 GFLRHIRAQRNFLVQTEEQYIFLHDALVEAIAS 915
            |.:..:|.||..:|||::|:.|:|    ..|||
Worm   338 GLVMTLRKQRASMVQTQDQFQFVH----RCIAS 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	93/293 (32%)
		PTPc	676..911	CDD:238006	86/247 (35%)
		PTPc	935..1186	CDD:214550
		PTPc	963..1169	CDD:238006
ptpn-22	NP_500128.2	PTPc	102..365	CDD:214550	89/277 (32%)
ptpn-22	NP_500128.2	PTPc	129..365	CDD:238006	86/250 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810