DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and F25H5.7

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_492454.1	Gene:	F25H5.7 / 172740	WormBaseID:	WBGene00009129	Length:	490	Species:	Caenorhabditis elegans

Alignment Length:	358	Identity:	99/358 - (27%)
Similarity:	160/358 - (44%)	Gaps:	62/358 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   600 DDPPHHPNAPQVDWEVPVKIGDEIRAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDLP 664
            :.||...:.|:..|        ..:||   ....:.::.||.|...|:               :|
Worm   154 EQPPEPGSDPRKIW--------AFKAA---KMKCQAISKLHQDKIKGY---------------MP 192

  Fly   665 --CEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQKGHA-FIGTQGPL 726
              |.::.:..|...|||.::...:.:||.|     :..:.|||:|:::....|..: :|.|||||
Worm   193 PNCTYTAYDANPDLNRYADVRCIEETRVVL-----KNHDRDYIHASWMRMPGKDQSTYITTQGPL 252

  Fly   727 PDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPK--DGVETYGVIQVKLIE--EEVMSTY 787
            |:|...||.||:::::|.::|:..|.|.|..||.:|:|:  ..|..:|..::.|.|  ||.::..
Worm   253 PETLSDFWHMIYQEKIAYVLMLCTLFEGGVEKCALYYPEKLGEVVKFGKYEITLTECKEEAIAGT 317

  Fly   788 TVRTLQIKHLKLKKKKQCNTEKLVYQYHYTN------WPDHGTPDHPLPVLNFVKKSSAANPAEA 846
            ....|.:          .|||....:..|.|      |||...|:...|::...|.....||.|.
Worm   318 IWNALTV----------TNTEDASSEPLYMNHVQVPWWPDQLAPEDARPMIELYKWVKKVNPKET 372

  Fly   847 GPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVE 911
             ||.||||||||||.|::.:|....:|.:...:.:...:|.:||.|...||:..|::||:..|:|
Worm   373 -PICVHCSAGVGRTATFVGIDYATIRIMENPNIEMLDIVREMRAMRFQAVQSHMQFLFLYVVLME 436

  Fly   912 AIASGETNLMAEQVEELKNCTPYLEQQYKNIIQ 944
                   ..:.|.|.|..........|||...|
Worm   437 -------YFIGEGVVERTGRVDTFMTQYKKHAQ 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	82/277 (30%)
		PTPc	676..911	CDD:238006	78/245 (32%)
		PTPc	935..1186	CDD:214550	4/10 (40%)
		PTPc	963..1169	CDD:238006
F25H5.7	NP_492454.1	PTPc	192..436	CDD:214550	81/259 (31%)
F25H5.7	NP_492454.1	PTPc	205..436	CDD:238006	78/246 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810