DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and T22C1.8

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_492194.1	Gene:	T22C1.8 / 172571	WormBaseID:	WBGene00011918	Length:	591	Species:	Caenorhabditis elegans

Alignment Length:	408	Identity:	107/408 - (26%)
Similarity:	183/408 - (44%)	Gaps:	58/408 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   589 RKCFHAAYYYLDDPPHHPNAPQVDWEVPVKIGDEIRAAVPVNEFAKHVASLHA---------DGD 644
            |.|.|..:.  .|...|.|..:....:|:| ||      |:::..|.|....|         :..
Worm    73 RACSHPVWN--PDKKIHFNNEKTHAIIPLK-GD------PLSDVQKKVFFKFASDAVKKNPPEYS 128

  Fly   645 IGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANF 709
            :.|..:.:....:      |.|......|..||||.::...|.:||.|    ....:.|||:||:
Worm   129 VEFMTKVKPYPGQ------PMERKIFDANPTKNRYKDVVCNDITRVIL----SDGGDGDYIHANY 183

  Fly   710 IDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVE--TYG 772
            ::|...  .||.|||....|...||||:...:.|.|||:..::|.|:.||..|:|:...|  |:|
Worm   184 VNGLNA--PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFG 246

  Fly   773 VIQVKL-IEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVK 836
            ...:.. :|::..:....|||.::::...|      |.::...|..:|||...|:..:.:|..:.
Worm   247 AWTILCSLEDDKDANIIKRTLSVRNVDNGK------EHILKHLHTKSWPDRCVPNSTMALLRMLY 305

  Fly   837 KSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQ 901
            ....|    :||:.||||||:|||||::.::|.|:.:.....:::.|..|.:|..|...:|.:.|
Worm   306 IVRTA----SGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQ 366

  Fly   902 YIFLHDALVEAIAS-GETNLMAEQVEELKNCTPYLEQQYKNIIQFQPKDIHIAS--AMKQVNSIK 963
            |:    |||:.:.: |:.|...:. .:|.:....|....:..||.:.|..|:.:  :...:|
Worm   367 YM----ALVQILINYGKDNGYWDD-SDLDDRVELLTWNIQQFIQTRGKVDHVPTTPSTPALN--- 423

  Fly   964 NRGAIFPIEGSRVHLTPK 981
                |.|.:...|.:.||
Worm   424 ----IIPADAKPVPVVPK 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	78/267 (29%)
		PTPc	676..911	CDD:238006	74/237 (31%)
		PTPc	935..1186	CDD:214550	11/49 (22%)
		PTPc	963..1169	CDD:238006	5/19 (26%)
T22C1.8	NP_492194.1	PTPc	130..376	CDD:214550	79/271 (29%)
T22C1.8	NP_492194.1	PTPc	153..376	CDD:238006	75/242 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810