DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and egg-5

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_491316.1	Gene:	egg-5 / 172007	WormBaseID:	WBGene00020035	Length:	753	Species:	Caenorhabditis elegans

Alignment Length:	755	Identity:	156/755 - (20%)
Similarity:	262/755 - (34%)	Gaps:	248/755 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   381 HDNQTGVEIVKNSRNSVETLIHFELQNLRPYTDYRVIVKAFTTKNEGEP------SDQIAQRTDV 439
            :..|.||..::...||..||          ...:|..||....|:....      |::.|.....
Worm    53 YPQQKGVSCMRARFNSESTL----------SKSFRKKVKKLAQKDRRSKERLNGNSEEDAIEVPR 107

  Fly   440 GGPS---APAIVN----LTCHSQESITIRWRRPYEFYNTIDFYIIKTRLAGQDTHRDIRINA--- 494
            |.||   ||:.:.    |.|...|......|.....:.. |..:.|...      .|:|:..
Worm   108 GAPSTYAAPSKLRKSKALDCLVSEKPKDEGRSEDSGHGA-DIEMAKGHF------NDVRMKVFAA 165

  Fly   495 -SAKELETAMILQNLTTNSYYEVKVAA-------ATFSVINPKKIVLGKFSESRIIQLQPNCEK- 550
             :|.::|.|::::   |....|:|.|.       ..||:....||...  :|||:..:.| |.|
Worm   166 RTAMQVEPALVMK---TRKALEMKNAVLENHQSPGAFSLHAAYKIAAS--AESRVGSITP-CNKK 224

  Fly   551 -----LQPLLRQSHNDYNLAVLVGIIFSCFGIILIIMAFF--LWSRKCFHAAYYYLDDPPHHPNA 608
                 :..|:|.|::|  ..:...::||         :.|  .|..: :...|...|:....|..
Worm   225 VTKEAMANLIRSSYDD--TEITQELLFS---------SKFDSKWKGR-YTDIYMRRDENGKKPKR 277

  Fly   609 P--QVDWEVPVK-----------------------------------------IGDEIRAAVPVN 630
            |  ...|.:|:|                                         |.|....||...
Worm   278 PVNGQGWVMPLKSICEKFGINSTFFTNHRIDLKSARDQVLLMRLLSHDQTSTWISDIHPEAVKNE 342

  Fly   631 EFAKHV-----------------ASLHADGDI--------------------------------G 646
            ..|:::                 |::.||.|.                                |
Worm   343 TLAEYLLRELDASTMQKRVQAFKANVLADRDRVRVAGQFYNNIRIGKRMFGAARKAKYLSTIIGG 407

  Fly   647 FSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFID 711
            ..|.:|.::|..  :.:|..||....|:.|.|...:...|.:|:.|....||... |:|:||.|.
Worm   408 MERRFEILENSV--NHIPFTHSASDNNQEKCRNPRVHCRDSTRIALQFPRGQYLG-DFIHANRIS 469

  Fly   712 GYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKD---------- 766
            |....:.||.||.|:.:|.|.||||:|::.|..|||:|:..|..|  |:.||||.
Worm   470 GKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPER--CEYYWPKSPSDPAVTVPG 532

  Fly   767 --GVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKL----KKKKQCNTEKLVYQYHYTNWPDHGTP 825
              .:|.:||.|.           .....::.||:|    ::::           |..:|  .|..
Worm   533 GLRIENFGVYQA-----------PDPLFRVTHLRLIGPDREER-----------HVEHW--QGDV 573

  Fly   826 DH------PLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLD----AMLKQIQQKNIVN 880
            ::      ||.:|..::.:|.       |:|:|...||.|....:..:    ::|:....|..|.
Worm   574 NNSSNMYSPLNILRLLRNASK-------PVVIHDHLGVSRAACLVAAEIAICSLLRGPTYKYPVQ 631

  Fly   881 VFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELKNCTPYLEQQYKNIIQF 945
              ..::.:|.:|.|.::|..||||:|            .|:|....::......|:..|:..:|.
Worm   632 --RAVQFLRQRRPFSIETPMQYIFVH------------RLVAFFFRDVIGSAKELDVDYERWLQE 682

  Fly   946 QPKDIHIASAMKQVNSIKNRGAIFPIEGSRVHLTPKPGED 985
            :.:.:.:.....            ||.|.|: |:|:...|
Worm   683 RSERMFLDDLAA------------PIPGYRL-LSPRADPD 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020	13/61 (21%)
		FN3	442..520	CDD:238020	18/88 (20%)
		PTPc	646..911	CDD:214550	77/290 (27%)
		PTPc	676..911	CDD:238006	69/260 (27%)
		PTPc	935..1186	CDD:214550	10/51 (20%)
		PTPc	963..1169	CDD:238006	7/23 (30%)
egg-5	NP_491316.1	PTPc	407..660	CDD:214550	78/302 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910