DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and F47B3.7

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_491276.1	Gene:	F47B3.7 / 171983	WormBaseID:	WBGene00018531	Length:	374	Species:	Caenorhabditis elegans

Alignment Length:	282	Identity:	89/282 - (31%)
Similarity:	141/282 - (50%)	Gaps:	48/282 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   650 EYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQ 714
            |:..:.|:  :.::|.:  ....|..||||.:|...:.:||.| .|.|...  |||:||::....
Worm    71 EFSEVANK--NPNVPVD--AFKSNPEKNRYTDIKCIEKTRVIL-TTDGASS--DYIHANYVGISI 128

  Fly   715 KGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLI 779
            |...||.||||...|...||.|:.:..|..|:|:..::|..|.||:.|||....:|
Worm   129 KPKKFICTQGPKDSTIYDFWAMVIQDNVESIIMLCKVIELARVKCEQYWPAVEGQT--------- 184

  Fly   780 EEEVMSTYTVR--TLQIKHLKLKKKKQ-------CNTE-------KLVYQYHYTNWPDHGTPDHP 828
                 :||..:  |:.|.:|.:.....       .|.|       :.:..|.:|||||||.|...
Worm   185 -----NTYVSKGHTITINNLGVGTLSPDDDFINVTNLELVWAGKTRSITHYQWTNWPDHGAPPIN 244

  Fly   829 LPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYI----VLDAMLKQIQQKNIVNVFGFLRHIR 889
            :..:|.::   |.| .:..|:||||||||||:||.:    ::|.|::.|..|::..:   :..||
Worm   245 MGAINLIE---AVN-YDTNPVVVHCSAGVGRSGTIVGISLIMDKMIQGINCKDMKKL---VEEIR 302

  Fly   890 AQRNFLVQTEEQYIFLHDALVE 911
            .||::.:|||.||:::|..|:|
Worm   303 NQRHYAIQTEAQYMYIHRVLLE 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	88/280 (31%)
		PTPc	676..911	CDD:238006	84/254 (33%)
		PTPc	935..1186	CDD:214550
		PTPc	963..1169	CDD:238006
F47B3.7	NP_491276.1	Y_phosphatase	90..324	CDD:278528	85/257 (33%)
F47B3.7	NP_491276.1	PTPc	92..324	CDD:238006	84/255 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810