DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and egg-4

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_491269.1	Gene:	egg-4 / 171980	WormBaseID:	WBGene00020652	Length:	753	Species:	Caenorhabditis elegans

Alignment Length:	761	Identity:	155/761 - (20%)
Similarity:	259/761 - (34%)	Gaps:	260/761 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   381 HDNQTGVEIVKNSRNSVETLIHFELQNLRPYTDYRVIVKAFTTKNEGEP------SDQIAQRTDV 439
            :..|.||..::...||..||          ...:|..||....|:....      |::.|.....
Worm    53 YPQQKGVSCMRARFNSESTL----------SKSFRKKVKKLAQKDRRSKERLNGNSEEDAIEVPR 107

  Fly   440 GGPS---APAIVN----LTCHSQESITIRWRRPYE-----------FYNTIDFYIIKTRLAGQDT 486
            |.||   ||:.:.    |.|...|......||...           .:|.:...:...|
Worm   108 GAPSTYAAPSKLRKSKALDCLVSEKPKDEGRREDSGHGADIEMAKGHFNNVRMKVFAAR------ 166

  Fly   487 HRDIRINASAKELETAMILQNLTTNSYYEVKVAA-------ATFSVINPKKIVLGKFSESRIIQL 544
                    :|.::|.|::::   |....|:|.|.       ..||:....||...  :|||:..:
Worm   167 --------TAMQVEPALVMK---TRKALEMKNAVLENHQSPGAFSLHAAYKIAAS--AESRVGSI 218

  Fly   545 QPNCEK------LQPLLRQSHNDYNLAVLVGIIFSC-FGIILIIMAFFLWSRKCFHAAYYYLDDP 602
            .| |.|      :..|:|.|::|  ..:...::||. |..        .|..: :...|...|:.
Worm   219 TP-CNKKVTKEAMANLIRSSYDD--TEITQELLFSSKFDT--------KWKGR-YTDIYMRRDEN 271

  Fly   603 PHHPNAP--QVDWEVPVK-----------------------------------------IGDEIR 624
            ...|..|  ...|.:|:|                                         |.|...
Worm   272 GKKPKRPVNGQGWVMPLKSICEKFGINSTFFTNHRIDLKSARDQVLLMRLLSHDQTSTWISDIHP 336

  Fly   625 AAVPVNEFAKHV-----------------ASLHADGDI--------------------------- 645
            .||.....|:::                 |::.||.|.
Worm   337 EAVKNETMAEYLLRELDASTMQKRVQAFKANVLADRDRVRVAGQFYNNIRIGKRMFGAARKAKYL 401

  Fly   646 -----GFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYI 705
                 |..|.:|.::|..  :.:|..||....|:.|.|...:...|.:|:.|....||... |:|
Worm   402 STIIGGMERRFEILENSV--NHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLG-DFI 463

  Fly   706 NANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKD---- 766
            :||.|.|....:.||.||.|:.:|.|.||||:|::.|..|||:|:..|..|  |:.||||.
Worm   464 HANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPER--CEYYWPKSPSDP 526

  Fly   767 --------GVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKL----KKKKQCNTEKLVYQYHYTNW 819
                    .:|.:||.|.           .....::.||:|    ::::           |..:|
Worm   527 AVTVPGGLRIENFGVYQA-----------PDPLFRVTHLRLIGPDREER-----------HVEHW 569

  Fly   820 PDHGTPDH------PLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLD----AMLKQIQ 874
              .|..::      ||.:|..::.:|.       |:|:|...||.|....:..:    ::|:...
Worm   570 --QGDVNNSSNMYSPLNILRLLRNASK-------PVVIHDHLGVSRAACLVAAEIAICSLLRGPT 625

  Fly   875 QKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELKNCTPYLEQQY 939
            .|..|.  ..::.:|.:|.|.::|..||||:|            .|:|....::......|:..|
Worm   626 YKYPVQ--RAVQFLRQRRPFSIETPMQYIFVH------------RLVAFFFRDVIGSAKELDVDY 676

  Fly   940 KNIIQFQPKDIHIASAMKQVNSIKNRGAIFPIEGSRVHLTPKPGED 985
            :..:|.:.:.:.:.....            ||.|.|: |:|:...|
Worm   677 ERWLQERSERMFLDDLAA------------PIPGYRL-LSPRADPD 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020	13/61 (21%)
		FN3	442..520	CDD:238020	17/95 (18%)
		PTPc	646..911	CDD:214550	77/290 (27%)
		PTPc	676..911	CDD:238006	69/260 (27%)
		PTPc	935..1186	CDD:214550	10/51 (20%)
		PTPc	963..1169	CDD:238006	7/23 (30%)
egg-4	NP_491269.1	PTPc	407..660	CDD:214550	78/302 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19134
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910