DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and Y48G1C.5

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_490668.4	Gene:	Y48G1C.5 / 171595	WormBaseID:	WBGene00021678	Length:	1161	Species:	Caenorhabditis elegans

Alignment Length:	468	Identity:	94/468 - (20%)
Similarity:	166/468 - (35%)	Gaps:	158/468 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   547 NCEKLQPLLRQSHNDYNLAVLVGIIFSCFGIILIIMAFFLWSRKCFHAAYYYLDDPPHHPNAPQV 611
            |.||..| ..|:|..|.:..|:.|:     ||..|:|:|..:                 ||..::
Worm   772 NSEKNGP-PPQTHGQYVILALIVIV-----IICAIIAYFCLT-----------------PNGYKI 813

  Fly   612 -DWEVPVKI--GDEIRAAVPVNE--FAKHVASLHADGDIGFSRE------YEAIQN--ECISDDL 663
             |.|...|:  .:::.:.|.|||  |:..:.:.:.......:|:      :|.:.|  |...||.
Worm   814 LDSEEKEKLYPPNQMISRVDVNETRFSNFLKTFNTQISDFVTRKRNCTSVFENVPNNLEITGDDF 878

  Fly   664 ------------PCEHSQHPENKRKN---RYLNITAYDHS-RVHLHPTPG---QKKNLDYINANF 709
                        .|:...: |:.:||   ...::...|:. :..|.|.|.   .||:.|.:
Worm   879 AQFCGLQGGNHCQCDPVSY-ESSKKNGQGESSHVVELDNGLKFVLMPAPQLPVDKKSSDIL---- 938

  Fly   710 IDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVE------RGRRKCDMYWPKDGV 768
                               ....||..:...:.:.|||:.:..|      ..:..||.|:|.:
Worm   939 -------------------AIAAFWESVKLNKPSTIVMLCDFAEIDHFIGANKVNCDRYFPTE-- 982

  Fly   769 ETYGVIQVKLIEEEVMSTYT-------VRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPD 826
                 :..|||..::..|.|       ::|.|:. |...||:   |:::.: |.||.||:|..|.
Worm   983 -----LDEKLILADLTITCTKSISKPLLKTRQLL-LTFGKKR---TQEVTH-YQYTGWPEHMGPK 1037

  Fly   827 HPLPV---LNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVFGFLRHI 888
            ....:   |..|..|..       |:.|.|:.|.||:..:::::::.:.|
Worm  1038 DAEEIRYLLKLVTDSER-------PVFVVCNTGGGRSAAFVLIESLFQAI--------------- 1080

  Fly   889 RAQRNFLVQTEEQYIFLHDALVEAIASGETNL--MAEQVEELKNCTP----YLE-QQYKNIIQFQ 946
                    .|.|              :||.|.  :.||....:.|..    ||. ..|..:..|.
Worm  1081 --------NTSE--------------TGEINYRSLIEQTRSKRKCAAPDPIYLAFAFYTTLTLFY 1123

  Fly   947 PKDIHIASAMKQV 959
            |.:.|..:.:.|:
Worm  1124 PANAHDDAYVTQI 1136

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	57/307 (19%)
		PTPc	676..911	CDD:238006	49/257 (19%)
		PTPc	935..1186	CDD:214550	6/26 (23%)
		PTPc	963..1169	CDD:238006
Y48G1C.5	NP_490668.4	WSN	47..111	CDD:280385
Y48G1C.5	NP_490668.4	PTPc	<940..1085	CDD:304379	40/200 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900