Protein Alignment Ptp99A and ptpra

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: NP_571963.2
• Gene: ptpra / 140818
• ZFINID: ZDB-GENE-020107-1
• Length: 831
• Species: Danio rerio
• Alignment Length: 657
• Identity: 223/657 - (33%)
• Similarity: 349/657 - (53%)
• Gaps: 64/657 - (9%)

  Fly   563 NLAVLVGIIFSCFGIILIIMAFFLWSRKCFHAAYYYL-----DDP-----PHHPNAPQVDWEVPV 617
            :|.|:|.||     |||.::.|..:.:...|:..:.|     ||.     |....:|..:.:.|
Zfish   190 SLLVIVFII-----IILYMLRFKKYKQAGSHSNSFRLTNGRADDTELQSVPLLARSPSTNRKYP- 248

  Fly   618 KIGDEIRAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDLP-------CEHSQHPENKR 675
                    .:||::..:.:....||.:..|..|:.|         ||       |:.:...|||.
Zfish   249 --------PLPVDKLEEEMNRRMADDNKLFREEFNA---------LPVCPIQASCDAASKEENKE 296

  Fly   676 KNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQ 740
            ||||:||..||||||||....|...: |||||::|:|||:.:.||..|||..:|.:.:|||||||
Zfish   297 KNRYVNILPYDHSRVHLTSLEGVPDS-DYINASYINGYQEKNKFIAAQGPKEETVNDYWRMIWEQ 360

  Fly   741 RVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHL-KLKKKKQ 804
            ..|.|||:|||.||...||..|||..|..|||.|:|.:.:..::..||:|...|:.: .:..||
Zfish   361 NTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDTMILVDYTIRKFCIQQVGDVSGKK- 424

  Fly   805 CNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAM 869
              .::||.|:|:|:|||.|.|..|:.:|.|:||....||..||||:||||||||||||:||:|||
Zfish   425 --PQRLVTQFHFTSWPDFGVPFTPIGMLKFLKKVKNCNPQYAGPIMVHCSAGVGRTGTFIVIDAM 487

  Fly   870 LKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELKN---- 930
            |..:..:..|:||||:..|||||..:|||:.||:|:..||:|....|:|.|....:|...|
Zfish   488 LDMMGAERKVDVFGFVTRIRAQRCQMVQTDMQYVFIFQALLEHYLYGDTELEVTSLETHMNKLYA 552

  Fly   931 ------CTPYLEQQYKNIIQFQPKDIHIASAMKQVNSIKNRG-AIFPIEGSRVHLTPKPGEDGSD 988
                  |.. ||.::|.:...:.::..:.:.....|..|||. .|.|.|.:||.:..|.||:.:|
Zfish   553 PLPGAGCGG-LEAEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTD 616

  Fly   989 YINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDD---INFAQFWPDEAT 1050
            |||||::.|:|:...::..|.|:.|||:|:|:|:|:..:.::|:|:.|::   ...||:||.:..
Zfish   617 YINASFIDGYRQKDSYMACQGPLQHTIEDYWRMIWEWRSCSIVMLTELEERGQEKCAQYWPTDGV 681

  Fly  1051 PIESDHYRVKFLNKTNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNPN---SIYDFIVDV 1112
            .:..| ..::...:.....|..||.::.:.:::....|:..|...|||:..|:   .:.:.|..|
Zfish   682 MVCGD-MSIELKREEESESYTVRDLLVTNNRENKSRAVRQFHFHGWPEVGIPSDGKGMINIIAAV 745

  Fly  1113 HERCNDYRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSEDI 1177
            .::.....|.||.:....|..:..||||:|::...::.....:|:|..|....:||.:..:.|..
Zfish   746 QKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQY 810

  Fly  1178 RVIYNIL 1184
            ...|.::
Zfish   811 EFCYKVV 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		FN3	243..337	CDD:238020
		fn3	343..430	CDD:394996
		FN3	442..520	CDD:238020
		R5-PTPc-1	704..907	CDD:350397	102/203 (50%)
		R5-PTP-2	989..1182	CDD:350398	50/198 (25%)
ptpra	NP_571963.2	PHA03255	<55..>176	CDD:165513
		R-PTPc-A-1	243..538	CDD:350469	137/316 (43%)
		R-PTPc-A-2	592..819	CDD:350471	61/227 (27%)