DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and EGFLAM

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_001192230.1	Gene:	EGFLAM / 133584	HGNCID:	26810	Length:	1017	Species:	Homo sapiens

Alignment Length:	380	Identity:	85/380 - (22%)
Similarity:	144/380 - (37%)	Gaps:	80/380 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 LLAVNKLGISPPSKESYYIVTLREAPTGKPIPTTAHNTSSTSVYISWKAP--PPDTILGEFLGYR 278
            ||..:.||   |...|......:....|.|:.......:.|:..|.||.|  |...|    |||.
Human    12 LLLASSLG---PGAVSLRAAIRKPGKVGPPLDIKLGALNCTAFSIQWKMPRHPGSPI----LGYT 69

  Fly   279 ITYRPRDRDPNDTKEIY----IRDNTVESHEIQNLQTYTQYKVTVQVFNPEGLG----PETTILV 335
            :.|.....|.:..::::    .||.......|.:|:..|:|:|::..::..|.|    |.....:
Human    70 VFYSEVGADKSLQEQLHSVPLSRDIPTTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTL 134

  Fly   336 MTDEGV-PSKPQNLTILDVSANSITMSWHPPKNQNGAIAGYHVFHIHDNQTGVEIVKNSRNSVET 399
            ..|..: |:.||...::.||.:.:.:||.|..::..|...|:         .||.::...:...|
Human   135 SQDSCLPPAAPQQPHVIVVSDSEVALSWKPGASEGSAPIQYY---------SVEFIRPDFDKKWT 190

  Fly   400 LIHFELQ-------NLRPYTDYRVIVKAFTTKNEGEPSDQIAQRTDVGGPSAPAIVNLTCHSQES 457
            .||..:|       .|.|.|:|:..|:|.   |...||.:          |.|:.:..|...:|:
Human   191 SIHERIQMDSMVIKGLDPDTNYQFAVRAM---NSHGPSPR----------SWPSDIIRTLCPEEA 242

  Fly   458 ITIRWRRPYEFYNTIDFYIIKTRLAGQDT---HRDIRINASAKELETAMILQNLTTNSYYEVKVA 519
            .:.|:...|          |....||:|.   ..|:.::.|.:|::..    ..|.....:..|.
Human   243 GSGRYGPRY----------ITDMGAGEDDEGFEDDLDLDISFEEVKPL----PATKGGNKKFLVE 293

  Fly   520 AATFSVINPKKIVLGKFSESRIIQLQPNCEKL-------QPLLRQSHNDYNLAVL 567
            :...|:.|||.|       ||:|  .|....|       ||:..|......:|::
Human   294 SKKMSISNPKTI-------SRLI--PPTSASLPVTTVAPQPIPIQRKGKNGVAIM 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	6/19 (32%)
		fn3	249..331	CDD:278470	22/91 (24%)
		FN3	342..437	CDD:238020	25/101 (25%)
		FN3	442..520	CDD:238020	15/80 (19%)
		PTPc	646..911	CDD:214550
		PTPc	676..911	CDD:238006
		PTPc	935..1186	CDD:214550
		PTPc	963..1169	CDD:238006
EGFLAM	NP_001192230.1	FN3	36..133	CDD:238020	24/100 (24%)
		FN3	142..234	CDD:238020	27/113 (24%)
		LamG	391..541	CDD:238058
		EGF_CA	560..602	CDD:238011
		LamG	618..765	CDD:238058
		EGF_CA	<792..820	CDD:238011
		Laminin_G_2	868..993	CDD:280389
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900