DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and Ptpn23

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_476552.2	Gene:	Ptpn23 / 117552	RGDID:	619892	Length:	1666	Species:	Rattus norvegicus

Alignment Length:	419	Identity:	112/419 - (26%)
Similarity:	180/419 - (42%)	Gaps:	89/419 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   601 DPPHHPNAPQVDWEVPVKIGDEIRAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDLPC 665
            ||..||...|       |:..|:.:               ..|.:|.:...:|:..|.      .
  Rat  1193 DPYEHPERLQ-------KLQQELES---------------FRGQLGDAGALDAVWREL------Q 1229

  Fly   666 EHSQHPENKR----------KNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQK-GHAF 719
            |..:|....|          |||:.::..||.:||.|.  .|:.   |||||:.::|... ....
  Rat  1230 EAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLR--SGKD---DYINASCVEGLSPYCPPL 1289

  Fly   720 IGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVE--TYGVIQVKLIEEE 782
            :.||.|||.|...||.|:.||:|::|||:.:..|..::|...|:|.:..:  .:|.:.|.|....
  Rat  1290 VATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPIERGQPMVHGALSVALSSVR 1354

  Fly   783 VMSTYTVR--TLQIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSA----A 841
            ...|:..|  :||.:...||:       .||: .|:..||:.|.||.|..:|.|:::..|    .
  Rat  1355 TTDTHVERVLSLQFRDQSLKR-------SLVH-LHFPTWPELGLPDSPGNLLRFIQEVHAHYLHQ 1411

  Fly   842 NPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQ-KNIVNVFGFLRHIRAQRNFLVQTEEQYIFL 905
            .|... |||||||:||||||.:.:|.|.:::::. ..|..:...:|.:|.||..::|.:....|.
  Rat  1412 RPLHT-PIVVHCSSGVGRTGAFALLYAAVQEVEAGSGIPELPQLVRRMRQQRKHMLQEKLHLKFC 1475

  Fly   906 HDALVEAIASGETNLMAEQVEELKNCTP--------------YLEQQYKNIIQFQPKDIHIASAM 956
            |:|||..:         |||.:.....|              :|.|..::::  ...|:.|:|..
  Rat  1476 HEALVRHV---------EQVLQRHGVPPPGKPVASMSVSQKSHLPQDSQDLV--LGGDVPISSIQ 1529

  Fly   957 KQVN--SIKNRGAIFPIEGSRVHLTPKPG 983
            ..:.  ||:..|.:.....|...|...||
  Rat  1530 ATIAKLSIRPLGGLDSPAASLPSLVEPPG 1558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	87/284 (31%)
		PTPc	676..911	CDD:238006	81/244 (33%)
		PTPc	935..1186	CDD:214550	12/51 (24%)
		PTPc	963..1169	CDD:238006	5/21 (24%)
Ptpn23	NP_476552.2	BRO1_HD-PTP_like	2..357	CDD:185762
		V_HD-PTP_like	362..702	CDD:185747
		ALIX_LYPXL_bnd	417..703	CDD:290660
		Y_phosphatase	1250..1480	CDD:278528	80/243 (33%)
		PTPc	1250..1479	CDD:238006	79/242 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900