DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp99A and Ptpn12

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	NP_476456.2	Gene:	Ptpn12 / 117255	RGDID:	620894	Length:	766	Species:	Rattus norvegicus

Alignment Length:	842	Identity:	201/842 - (23%)
Similarity:	328/842 - (38%)	Gaps:	184/842 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   629 VNEFAKHVASLHA---DGDIGFSREYEAI-------QNECISDDLPCEHSQHPENKRKNRYLNIT 683
            :..|.:.|.::.:   :|:..|:|::..:       :.|.|   .|....:..||.:||||.:|.
  Rat     7 LRRFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKI---YPTATGEKEENVKKNRYKDIL 68

  Fly   684 AYDHSRVHLH-PTPGQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVM 747
            .:|||||.|. .||.|  :.||||||||.|.....|::.|||||.:|...|||||||..|.||||
  Rat    69 PFDHSRVKLTLKTPSQ--DSDYINANFIKGVYGPRAYVATQGPLANTVIDFWRMIWEYNVVIIVM 131

  Fly   748 ITNLVERGRRKCDMYWPKDGVE--TYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKL 810
            .....|.||:||:.|||..|.:  |:...::....|:..:.|.:|||.::..        |..:.
  Rat   132 ACREFEMGRKKCERYWPLYGEDPITFAPFKISCENEQARTDYFIRTLLLEFQ--------NESRR 188

  Fly   811 VYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLD---AMLKQ 872
            :||:||.|||||..|.....:|:.:.........|..||.:|||||.||||....:|   .:||.
  Rat   189 LYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKA 253

  Fly   873 IQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELKNCTPYLEQ 937
            .:.....|||..::.:|.||:..|||:|||..:|.|:.:....
  Rat   254 GKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEK---------------------- 296

  Fly   938 QYKNIIQFQPKDIHIASAMKQVNSIKNRGAIFPIEGSRVHL-TPKPGEDGSDYINASWLHGFRRL 1001
                  |.|..:||.|..:...|.|.....:..|:..:... .|||....|..:...       .
  Rat   297 ------QLQLYEIHGAQKITDGNEISTGNMVSSIDSEKQDSPPPKPPRTRSCLVEGD-------A 348

  Fly  1002 RDFIVTQHPMAH---------------TIKDFWQMVWDHNAQTVVLLSSLDDINFAQFWPDEATP 1051
            ::.|: |.|..|               |:...||....::.:.|:.::|           .|..|
  Rat   349 KEEIL-QPPEPHPVPPILTPSPPSAFPTVTTVWQDSDRYHPKPVLHMAS-----------PEQPP 401

  Fly  1052 IESDHYRVKFLNKTNKSDYVSR-----DFVIQSIQDDYELTVKMLHCPSWPEMSNPNSIYD---- 1107
            .:.:.      |....:|.:.|     :...:.::.:....:|.:.....|:..:.|::.:
  Rat   402 TDLNR------NYDKSADLMGRSESAVEHTDKKLEQNLSFEIKKVPLQEGPKSFDGNTLLNRGHA 460

  Fly  1108 --------FIVDVHERCNDYRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYH 1164
                    .:||...:..:..:|.:.:.|  ....:|..|:.|.|         .|..:.::...
  Rat   461 IKIKSASSSVVDKSSKPQELSSGDLKVHD--VSQNSCADCSASHL---------DNAPESSEESQ 514

  Fly  1165 NK----RPGVWTSSEDIRVIYNILSFLPGNLNLLKRTALRTEFEDVTTATPDLYSKICSNVAPLS 1225
            |.    ||......:...|.:::..  |.|         .|...|    :||.:|:....|:...
  Rat   515 NSHTPPRPDCLPLDKKGHVTWSLHG--PEN---------ATPVSD----SPDNHSQTLKTVSSTP 564

  Fly  1226 SSSS------TTPPPPSTPTPQPPQTIQLSSH---SPSDLSHQISSTVANAGSPATASAGATPT- 1280
            :|::      .|....|:|.|:.|.:.....|   |.||..:...:...|..|.:||||..:|.
  Rat   565 NSTAEEESHDLTEHHNSSPLPRAPLSFTNPLHSDDSDSDEGNSDGAVTKNKTSISTASATVSPAS 629

  Fly  1281 ---TPMTPTVPPTIPTIPSLASQNSLTLTNANFHTVTNNAADLMEHQ---------QQQMLALMQ 1333
               :..|..|.|.     |:|.|...    ...|:.....||:.|..         :..:||.|.
  Rat   630 STESACTRRVLPM-----SIARQEMA----GRRHSGAEKDADVSEESPPPLPERTPESFVLADMP 685

  Fly  1334 QQTQLQQQYNTHPQQHHNNVGDLLMNN----ADNSPTA--SPTITNNNHITNNNVTSAAATD 1389
            .::...:..:....:|..:.|.:...|    |..|.||  |||.::.......::|.  .||
  Rat   686 IRSDWHELPSQECSEHRESEGLITSGNDKHDAGVSHTAACSPTFSDKKEEITESLTE--VTD 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	105/277 (38%)
		PTPc	676..911	CDD:238006	98/240 (41%)
		PTPc	935..1186	CDD:214550	42/287 (15%)
		PTPc	963..1169	CDD:238006	33/242 (14%)
Ptpn12	NP_476456.2	PTPc	28..292	CDD:214550	105/276 (38%)
Ptpn12	NP_476456.2	PTPc	60..292	CDD:238006	98/241 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810