Protein Alignment Ptp99A and Ptpru

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: XP_017448609.1
• Gene: Ptpru / 116680
• RGDID: 620782
• Length: 1452
• Species: Rattus norvegicus
• Alignment Length: 1388
• Identity: 343/1388 - (24%)
• Similarity: 574/1388 - (41%)
• Gaps: 321/1388 - (23%)

  Fly    11 NHRGLIIPGFVLLLILATLPATQAGRIFDVTNLDYVKVNAEAGKNVTIPCPGVNEHSLVDTLVWK 75
            :|:|.|....:||.......|....|:.|      |:||  ||:|.:..|......:..:....:
  Rat   169 DHKGYIGLDDILLFSHPCAKAPHFSRLGD------VEVN--AGQNASFQCMAAGRAAEAERFFLQ 225

  Fly    76 TASTTIAQFANRIPLLHSPRIQLLSDNFGLQFSPSLASDTSE---YICLVNDRHIPEA-----IV 132
            ..|..:...|.         ::.:|....|...|..:...||   |.|:   ...|..     ..
  Rat   226 RQSGVLVPAAG---------VRHISHRRFLATFPLASVGRSEQDLYRCV---SQAPRGAGVSNFA 278

  Fly   133 DLLVQDVPDPPERP---------LLISFTSRSVNLSWAHSQHPRNAPVTHFIIETREGEDGIWEQ 188
            :|:|::.|.|...|         |:|...:.|:         ..:.|:....||.|... |.|.:
  Rat   279 ELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSI---------IGDGPIVRKEIEYRMAR-GPWAE 333

  Fly   189 LARIYTKTNATSYQVTGLTPFTVYSFRLLAVNKLGISPPSKESYYIVTLREAPTGKPIPTTAHNT 253
            :..:    |..:|::..|.|.|.|...:|      ::.|.          :..||:|.|.....|
  Rat   334 VHAV----NLQTYKLWHLDPDTEYEISVL------LTRPG----------DGGTGRPGPPLLSRT 378

  Fly   254 SSTSVYISWKAPP----------PDTILGEFLGYRIT------------YRPRDRDPNDTKEIYI 296
            ....   ..:||.          ..|:..|.|||.:|            |..........:|...
  Rat   379 KCAE---PTRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYAVSLCYHYTLGGSHNQTIRECVK 440

  Fly   297 RDNTVESHEIQNLQTYTQYKVTVQVFNPEGLGPETTILVMTDEGVPS--KPQNLTILDVSANSIT 359
            .:.....:.|:||..:....|.:.:.||||......:...|||.||.  ..::||...:. :.|.
  Rat   441 MERGASRYTIKNLLPFRNVHVRLILTNPEGRKEGKEVTFQTDEDVPGGIAAESLTFTPLE-DMIF 504

  Fly   360 MSWHPPKNQNGAIAGYHVFH--IHDNQTGVEIVKNSRNSVETL---IHFELQNLRPYTDYRVIVK 419
            :.|..|:..||.|..|.:.:  |..:...|. |...|.::..|   .:....||:|.|.|...|:
  Rat   505 LKWEEPQEPNGLITQYEISYQSIESSDPAVN-VPGPRRTISKLRNETYHVFSNLQPGTTYLFSVR 568

  Fly   420 AFTTKNEGEPS-DQIAQRTDVGGPS-----APAIVNLTCHSQESITIRWR------RPYEFYNTI 472
            |.|:|..|:.: .:|.  |::..||     .|:.:.   .|:.:||:..|      .|...|..:
  Rat   569 ARTSKGFGQAALTEIT--TNISAPSFDYADMPSPLG---ESENTITVLLRPAQGRGAPISVYQVV 628

  Fly   473 DFYIIKTRLAGQDTHRDIRINASAKE-------LETAMILQNLTTNSYYEVKVAAAT------FS 524
                     ..::..|.:|.....::       .||| :.:.|.  .|:..::||::      |:
  Rat   629 ---------VEEERPRRLRREPGGQDCFSVPLTFETA-LARGLV--HYFGAELAASSLLEAMPFT 681

  Fly   525 V-------------INPKKIVLGKF-------SESRI----IQLQPNCEKLQPLLRQSHNDYNLA 565
            |             :.|:|..|..|       .|:|:    |..:..|::.:..|..|.....:.
  Rat   682 VGDNQTYRGFWNPPLEPRKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQRSEEMG 746

  Fly   566 VLVGIIFSCFG----IILIIMAFFLWSRK---CFHAAYY-------------------------- 597
            :::||   |.|    :||::.|..:..||   .:..:||
  Rat   747 LILGI---CAGGLAVLILLLGAIIIIIRKGRDRYAYSYYPKPVNMAKATVNYRQEKTHMMTAVDR 808

  Fly   598 -----------------YLDDPPHHPNAPQVDWEV--------------------PVKIGDEIRA 625
                             ::|.|.:.|...|....|                    |...| ::..
  Rat   809 SFTDQSTLQEDERLGLSFMDAPGYSPRGDQRSSGVTEASSLLGGSPRRPCGRKGSPYHTG-QLHP 872

  Fly   626 AVPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYDHSRV 690
            ||.|.:..:|:..:......||.:|||:...       ..:.::..:..:..|...::|||..||
  Rat   873 AVRVADLLQHINQMKTAEGYGFKQEYESFFE-------GWDATKKKDKLKSGRQEPVSAYDRHRV 930

  Fly   691 HLHPTPGQKKNLDYINANFID------GYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMIT 749
            .|||..|. .:.|||:||:||      ||.:.:.||.||||.|:....||||:|:::...:|||:
  Rat   931 KLHPMLGD-PDADYISANYIDIRINRQGYHRSNHFIATQGPKPEMIYDFWRMVWQEQCVSVVMIS 994

  Fly   750 NLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQY 814
            .|||.||.||..|||:|. :.||.|::.|::.|.::.|.|||..:      :::..:....|.|:
  Rat   995 KLVEVGRVKCSRYWPEDS-DMYGDIKITLVKTETLAEYVVRTFAL------ERRGYSARHEVRQF 1052

  Fly   815 HYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIV 879
            |:|.||:||.|.|...:|.|:::..|:.|.:|||:|:|||||.||||.|||||.||...:.:.:|
  Rat  1053 HFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPVVIHCSAGTGRTGCYIVLDVMLDMAECEGVV 1117

  Fly   880 NVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNL-----------------------M 921
            :::..::.:.::|..::||||||||:|||::||...|||.:                       :
  Rat  1118 DIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVNEFKATYREMIRIDPQSNSSQL 1182

  Fly   922 AEQVEELKNCTPYLEQQYKNIIQFQPKDIHIAS-AMKQVNSIKNRGA-IFPIEGSRVHLTPKPGE 984
            .|:.:.|.:.||             |.|:...| |:...|..|||.. :.|.:.....|....|
  Rat  1183 REEFQTLNSVTP-------------PLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISSDG- 1233

  Fly   985 DGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSLDDINFA----QFW 1045
            |.::||||:....:.|...||||.||:..|..|||::|:|:...::|:|:.|:..|.|    |:|
  Rat  1234 DPNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYW 1298

  Fly  1046 PDEATPIESDH--YRVKFLNKTNKSDYVSRDFVIQS---IQDDYELTVKMLHCPSWPE-MSNPNS 1104
            |:   |....:  ..|:|::.|...|.|||.|.:|:   :|:.: |.|:......|.. ...|:|
  Rat  1299 PE---PGRQQYGLMEVEFVSGTANEDLVSRVFRVQNSSRLQEGH-LLVRHFQFLRWSAYRDTPDS 1359

  Fly  1105 IYDF---IVDVHERCNDYRNGPIVIVDRYGGAQACTFCAISSLAIEMEYC-STANVYQYAKLYHN 1165
            ...|   :.:|.:...:..:|..|:....||.::.||||.::: :||..| |..:|:..||...|
  Rat  1360 RKAFLHLLAEVDKWQAESGDGRTVVHCLNGGGRSGTFCACATV-LEMIRCHSLVDVFFAAKTLRN 1423

  Fly  1166 KRPGVWTSSEDIRVIYNI-LSFL 1187
            .:|.:..:.:.....|:: |.:|
  Rat  1424 YKPNMVETMDQYHFCYDVALEYL 1446

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	20/104 (19%)
		FN3	243..337	CDD:238020	22/115 (19%)
		fn3	343..430	CDD:394996	24/93 (26%)
		FN3	442..520	CDD:238020	16/95 (17%)
		R5-PTPc-1	704..907	CDD:350397	87/208 (42%)
		R5-PTP-2	989..1182	CDD:350398	60/206 (29%)
Ptpru	XP_017448609.1	MAM	22..186	CDD:214533	5/16 (31%)
		fn3	291..365	CDD:394996	18/103 (17%)
		FN3	<347..>624	CDD:442628	68/302 (23%)
		fn3	494..577	CDD:394996	23/84 (27%)
		PTP_DSP_cys	943..1153	CDD:475123	92/216 (43%)
		R-PTPc-U-2	1238..1444	CDD:350485	61/210 (29%)