Protein Alignment Ptp99A and Ptpre

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: XP_038964618.1
• Gene: Ptpre / 114767
• RGDID: 620771
• Length: 719
• Species: Rattus norvegicus
• Alignment Length: 617
• Identity: 214/617 - (34%)
• Similarity: 328/617 - (53%)
• Gaps: 74/617 - (11%)

  Fly   606 PNAPQVDWEVPVK-IGDEIRAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDLPCEHSQ 669
            |:.|:..:.:||: :.:|||..             .||....|..|:         :.||..|.|
  Rat   125 PSGPKKYFPIPVEHLEEEIRVR-------------SADDCKRFREEF---------NSLPSGHIQ 167

  Fly   670 -------HPENKRKNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQKGHAFIGTQGPLP 727
                   ..||:.||||.||...||.||.|....|...: |||||::||||::.:.||..|||..
  Rat   168 GTFELANKEENREKNRYPNILPNDHCRVILSQLDGIPCS-DYINASYIDGYKEKNKFIAAQGPKQ 231

  Fly   728 DTFDCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTL 792
            :|.:.||||:||||.|.|||:|||.||...||..|||..|..|||.|:|.:.:..|:..||:|..
  Rat   232 ETVNDFWRMVWEQRSATIVMLTNLKERKEEKCYQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKF 296

  Fly   793 QIKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGV 857
            .| |.:|  ...|...:||.|.|:|:|||.|.|..|:.:|.|:||....||:.||||||||||||
  Rat   297 CI-HPQL--PDSCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPSHAGPIVVHCSAGV 358

  Fly   858 GRTGTYIVLDAMLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNL-- 920
            |||||:||:|||:..|..:..|:||.|:..||.||..:|||:.||.|::.||:|....|:|.|
  Rat   359 GRTGTFIVIDAMMDMIHSEQKVDVFEFVSRIRNQRPQMVQTDVQYTFIYQALLEYYLYGDTELDV 423

  Fly   921 --MAEQVEELKNCTPY-----LEQQYKNI--IQFQPKDI---HIASAMKQVNSIKNRGAIFPIEG 973
              :...::.|.....:     ||::::.:  ::...:::   ::.:.||:...|:    |.|.:.
  Rat   424 SSLERHLQTLHGTATHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQ----IIPYDF 484

  Fly   974 SRVHLTPKPGEDGSDYINASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLLSSL-- 1036
            :||.|:.|.|::.:||||||::.|:|:...|:.||.|:|||::|||:|||:..:.|:|:|:.:
  Rat   485 NRVILSMKRGQEFTDYINASFIDGYRQKDYFMATQGPLAHTVEDFWRMVWEWKSHTIVMLTEVQE 549

  Fly  1037 -DDINFAQFWPDEATPIESDHYRVKFLNKTNKSDYVS-----RDFVIQ-----SIQDDYELTVKM 1090
             :.....|:||.|.:....|      :....|||.:|     |||::.     :.|::....|:.
  Rat   550 REQDKCYQYWPTEGSVTHGD------ITIEIKSDTLSEAISIRDFLVTFKQPLARQEEQVRMVRQ 608

  Fly  1091 LHCPSWPEMSNP---NSIYDFIVDVHERCNDYRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCS 1152
            .|...|||:..|   ..:.|.|..|.::.....|.||.:....|..:..||.|:|::...::...
  Rat   609 FHFHGWPEVGIPTEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEG 673

  Fly  1153 TANVYQYAKLYHNKRPGVWTSSEDIRVIYNIL 1184
            ..:|:|..|....:||.:..:.|.....|.::
  Rat   674 LLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVV 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		FN3	243..337	CDD:238020
		fn3	343..430	CDD:394996
		FN3	442..520	CDD:238020
		R5-PTPc-1	704..907	CDD:350397	104/202 (51%)
		R5-PTP-2	989..1182	CDD:350398	59/208 (28%)
Ptpre	XP_038964618.1	R-PTPc-E-1	184..412	CDD:350468	116/231 (50%)
		PTP_DSP_cys	499..708	CDD:475123	61/213 (29%)