DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp99A and SPEG

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_011508781.1	Gene:	SPEG / 10290	HGNCID:	16901	Length:	3277	Species:	Homo sapiens

Alignment Length:	1467	Identity:	267/1467 - (18%)
Similarity:	455/1467 - (31%)	Gaps:	532/1467 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 LQFSPSLASDTSEYICLVNDRHIPE---AIVDLLVQDVPDPPERPLLISFTSRSVNLSWAHSQHP 166
            |...||||   ..:..|:.|..:.|   |..|..:...|.|.              ::|
Human  1066 LTVRPSLA---PLFTRLLEDVEVLEGRAARFDCKISGTPPPV--------------VTW------ 1107

  Fly   167 RNAPVTHFIIETREGEDGIWEQLARIYTKTNATSYQVTGLTPFTVYSFRLLAVNKLGISPPSKES 231
                 |||.....|.|:      .|:.......|..:..:.......:.:.|||..|.:..|.:.
Human  1108 -----THFGCPMEESEN------LRLRQDGGLHSLHIAHVGSEDEGLYAVSAVNTHGQAHCSAQL 1161

  Fly   232 YYIVTLREAPTGKPIPTTAHNTSSTSVYISWKAP--PPDTILGEF--LGYRITYRP-RDRDPNDT 291
            |    :.|       |.||.:..|:.:.   |.|  |.:...||.  |......|| :|.:....
Human  1162 Y----VEE-------PRTAASGPSSKLE---KMPSIPEEPEQGELERLSIPDFLRPLQDLEVGLA 1212

  Fly   292 KEIYIRDNTV-----------ESHEIQNL--QTYTQYKVTVQVFNPEGLGPE------TTI---- 333
            ||..:.....           ..|.||:.  :..|||:...::..| .:||:      :.|
Human  1213 KEAMLECQVTGLPYPTISWFHNGHRIQSSDDRRMTQYRDVHRLVFP-AVGPQHAGVYKSVIANKL 1276

  Fly   334 --------LVMTDEGVPSKPQNL-TILDVSANSITMSWHPPKNQNGAI----AGYHVFH-IHDNQ 384
                    |.:||. ||..|... .::.|:...:|::|:||::.:.||    ..|.|.| :..:.
Human  1277 GKAACYAHLYVTDV-VPGPPDGAPQVVAVTGRMVTLTWNPPRSLDMAIDPDSLTYTVQHQVLGSD 1340

  Fly   385 TGVEIVKNSRNS--VETLIHFELQNLRPYTDYRVIVKAFTTKNEGEPSD-----QIAQRTDVGGP 442
            ....:|...|..  ..|.:...:|::     :||:  :.|.|:..:||.     |:.:.    ||
Human  1341 QWTALVTGLREPGWAATGLRKGVQHI-----FRVL--STTVKSSSKPSPPSEPVQLLEH----GP 1394

  Fly   443 S---APA------IVNLTCHSQESITIRWRRPYEFYNTIDFYIIKTRLAG--------------- 483
            :   |||      ||.:......|:|:.       :|.::..::.....|
Human  1395 TLEEAPAMLDKPDIVYVVEGQPASVTVT-------FNHVEAQVVWRSCRGALLEARAGVYELSQP 1452

  Fly   484 QDTHRDIRI-NASAKEL-------------ETAMILQNLTTNSYYE-----VKVAA---ATFSVI 526
            .|....:|| ..|.:::             :|..:...|.....:|     |:|.|   |.|:|
Human  1453 DDDQYCLRICRVSRRDMGALTCTARNRHGTQTCSVTLELAEAPRFESIMEDVEVGAGETARFAV- 1516

  Fly   527 NPKKIVLGK------FSESRIIQLQPNCEKLQPLLRQSH-------NDYNLAVLV-----GIIFS 573
                :|.||      :.:..::           |...||       |:.:|.||.     |.:::
Human  1517 ----VVEGKPLPDIMWYKDEVL-----------LTESSHVSFVYEENECSLVVLSTGAQDGGVYT 1566

  Fly   574 CFGIILIIMAFFLWSRKCFHAAYYYLDDPPHHPNAPQVDWEVPVKIGDEIRAAVPVNEFAKHVAS 638
            |                                .|..:..||..|.           |.|.|.|.
Human  1567 C--------------------------------TAQNLAGEVSCKA-----------ELAVHSAQ 1588

  Fly   639 LHADGDIGFSREYEAIQNECISDDLPCEHSQHPENKRKNRYLNITAYD-HSRV------HLHPTP 696
                         .|::.|.:.:|         |:.|..|..:.  || |..:      :|....
Human  1589 -------------TAMEVEGVGED---------EDHRGRRLSDF--YDIHQEIGRGAFSYLRRIV 1629

  Fly   697 GQKKNLDYINANFIDGYQKGHAFIGTQGPLPDTF--DC--FWRMIWEQRVAIIVM----ITNLVE 753
            .:...|::. |.||....|..|....:..|....  ||  ::...:|:|..::::    ...|:|
Human  1630 ERSSGLEFA-AKFIPSQAKPKASARREARLLARLQHDCVLYFHEAFERRRGLVIVTELCTEELLE 1693

  Fly   754 RGRRK---CDMYWPKDGVETYGVIQVKLIEEEVM-STYTVRTLQIKHLKLKKK------------ 802
            |..||   |:.             :::....:|: ..:.:....:.||.:|.:
Human  1694 RIARKPTVCES-------------EIRAYMRQVLEGIHYLHQSHVLHLDVKPENLLVWDGAAGEQ 1745

  Fly   803 --KQC---NTEKLV---YQYHYTNWPDHGTPDHPLP-VLNFVKKSSAANPAEAGPIVVHCSAGVG 858
              :.|   |.::|.   .||     ..:|||:...| ::|....|...:....|.:...|..|:.
Human  1746 QVRICDFGNAQELTPGEPQY-----CQYGTPEFVAPEIVNQSPVSGVTDIWPVGVVAFLCLTGIS 1805

  Fly   859 -------RTGTYIVLDAMLKQIQQKNIV-NVFGFLRHIRAQRNFL-------------------- 895
                   ||        .|..|:..|:. ....||...|..|.||
Human  1806 PFVGENDRT--------TLMNIRNYNVAFEETTFLSLSREARGFLIKVLVQDRLRPTAEETLEHP 1862

  Fly   896 ----------VQTEEQYIFL-HDALVEAIASGETNLMAEQVEELKNCTPYLEQQYKNIIQFQPKD 949
                      |.|:...:|| ......:..|.:.:|:...:.||....|  |:.:..:.:..|..
Human  1863 WFKTQAKGAEVSTDHLKLFLSRRRWQRSQISYKCHLVLRPIPELLRAPP--ERVWVTMPRRPPPS 1925

  Fly   950 IHIASA-------MKQVNSIKNRGAIFPIE----GSRVHLTPKPGEDGSDYINASWLHGFRRLRD 1003
            ..::|:       ::::.|:..     |::    ||||.||..|.||                 :
Human  1926 GGLSSSSDSEEEELEELPSVPR-----PLQPEFSGSRVSLTDIPTED-----------------E 1968

  Fly  1004 FIVTQHPMAHTIKDFWQ-----MVWDHNAQTVVLLSSLDDINFAQFWP-----------DEATPI 1052
            .:.|....|.|..| ||     ...|..|.:...|.|......|...|           :.|.|.
Human  1969 ALGTPETGAATPMD-WQEQGRAPSQDQEAPSPEALPSPGQEPAAGASPRRGELRRGSSAESALPR 2032

  Fly  1053 ESDHYRVKFLNKT-----------------------NKSDYVSRDFVIQSIQDDYELTVKMLHCP 1094
            .......:.|:|.                       .:.:|..|   :|:::.      ::|.
Human  2033 AGPRELGRGLHKAASVELPQRRSPSPGATRLARGGLGEGEYAQR---LQALRQ------RLLR-- 2086

  Fly  1095 SWPEMSNPNSIYDFIVDVHERCNDYRNGPIVIVDRYGG-------AQACTFCAISSLAIEMEYCS 1152
            ..||....:.:               .||  :::..||       |:|.     ||.|..
Human  2087 GGPEDGKVSGL---------------RGP--LLESLGGRARDPRMARAA-----SSEAAP----- 2124

  Fly  1153 TANVYQYAKLYHNKRP----GVWTSSEDIRVIYNILSFLPGNL---NLLKRTALRTEFEDVTTAT 1210
                       |::.|    |:..||          ||..|..   ...:|.....|........
Human  2125 -----------HHQPPLENRGLQKSS----------SFSQGEAEPRGRHRRAGAPLEIPVARLGA 2168

  Fly  1211 PDLYSKICSNVAPLSSSSSTTPPPPSTPTPQPPQTIQLSSHSPSDLSHQISSTVANAGSPATASA 1275
            ..|...  .:::.||.:..::|..||.|.|..|::.:.|:.:|||.....:...|...:|   ..
Human  2169 RRLQES--PSLSALSEAQPSSPARPSAPKPSTPKSAEPSATTPSDAPQPPAPQPAQDKAP---EP 2228

  Fly  1276 GATPTTPMTPTVPP------TIPTIPSLASQNSLTLT 1306
            ...|.....|..||      .:|..|......||.|:
Human  2229 RPEPVRASKPAPPPQALQTLALPLTPYAQIIQSLQLS 2265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	16/95 (17%)
		fn3	249..331	CDD:278470	23/105 (22%)
		FN3	342..437	CDD:238020	23/107 (21%)
		FN3	442..520	CDD:238020	19/120 (16%)
		PTPc	646..911	CDD:214550	60/343 (17%)
		PTPc	676..911	CDD:238006	55/313 (18%)
		PTPc	935..1186	CDD:214550	50/311 (16%)
		PTPc	963..1169	CDD:238006	43/259 (17%)
SPEG	XP_011508781.1	I-set	43..125	CDD:254352
		Ig	45..125	CDD:299845
		I-set	732..821	CDD:254352
		Ig	755..822	CDD:299845
		SPEG_u2	822..878	CDD:293256
		I-set	879..969	CDD:254352
		IGc2	892..959	CDD:197706
		I-set	983..1068	CDD:254352	1/1 (100%)
		Ig	995..1065	CDD:143165
		I-set	1074..1163	CDD:254352	21/123 (17%)
		Ig	1091..1163	CDD:299845	18/106 (17%)
		I-set	1198..1287	CDD:254352	16/89 (18%)
		Ig	1215..1287	CDD:299845	11/72 (15%)
		I-set	1400..1490	CDD:254352	13/96 (14%)
		I-set	1495..1584	CDD:254352	24/147 (16%)
		Ig	1512..1581	CDD:143165	19/127 (15%)
		STKc_SPEG_rpt1	1608..1864	CDD:271010	50/284 (18%)
		S_TKc	1611..1864	CDD:214567	50/279 (18%)
		I-set	2594..2684	CDD:254352
		Ig	2615..2684	CDD:299845
		STKc_SPEG_rpt2	2972..3228	CDD:271013
		S_TKc	2976..3228	CDD:214567
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0613
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900