Protein Alignment Ptp99A and ptprg

DIOPT Version :10

• Sequence 1: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Sequence 2: XP_031757104.1
• Gene: ptprg / 100488629
• XenbaseID: XB-GENE-991516
• Length: 1411
• Species: Xenopus tropicalis
• Alignment Length: 1322
• Identity: 421/1322 - (31%)
• Similarity: 621/1322 - (46%)
• Gaps: 263/1322 - (19%)

  Fly     1 MTQRISATYGNHRGL--IIPG-----------FVLLLILATLPATQAGRIFDVTNLDYVKVNAEA 52
            |:....||..|:..|  ||.|           |:...||..|..:..|..:..|
 Frog   200 MSVFFQATQRNNPALDPIIHGLKGVVHHEKETFLDPFILRELLPSSLGSFYRYT----------- 253

  Fly    53 GKNVTIPCPGVNEHSLVDTLVWKTASTTIAQFANRIPLL-----------------HSPRIQLLS 100
            |...|.||..:.|        |       ..|:..:|:.                 |...:..|.
 Frog   254 GSLTTPPCSEIVE--------W-------VIFSRPVPISYHQLEAFYSIFTTEQQDHVKSVDYLR 303

  Fly   101 DNFGLQFSPSLASDTSEYICLVNDRHIPEAIVDLLVQDVP----------DPPERPLLISFTSRS 155
            :||..:.|   .:|.:.|...|.|...|: ::|.|  |.|          .||....:......:
 Frog   304 NNFRPRQS---LNDRAVYKSAVKDAWSPD-MMDYL--DSPFGTEASKVCSTPPVNMKVHPVNKTA 362

  Fly   156 VNLSWAHSQHPRNAPVTHFIIETREGEDGIW----EQLARIYTKTNATSYQ--VTGLTPFTVYSF 214
            :.::|...:...:.||..|::...      |    |...:.:||.|....:  :..:|...:|.|
 Frog   363 LLVTWNQPETIYHPPVISFMVSYS------WTKNDEAKEKTFTKENDKDLKAVINHVTADILYLF 421

  Fly   215 RLLAV--NKLGISPPSKESYYIVTLREAPTGK----------PIPTTAHNTSSTSVYIS-----W 262
            |:.||  |.|      :..:....|.:|.|.:          .:||.:..:|:....||     |
 Frog   422 RVQAVCQNDL------RSDFSQTMLFQANTTRIFEGTRIVKTGVPTVSPASSADMAPISSGSSTW 480

  Fly   263 KAPPPDTILGEFLGYRITYRPRDRDPNDTKEIYIRDNTVESHEIQ--NLQTY------TQYKVTV 319
            .:   ..|...|:.......|.......|....:....:......  .|.::      |:...||
 Frog   481 TS---SGIPFSFVSMATGMGPSSSGSQATVASVVTSTLLAGLGFSGGGLPSFPSTVWPTRLPTTV 542

  Fly   320 QVFNPEGLGPETTILVMTDEGVPSKPQNLTILDVSANSITMSWHPPKNQNGAIAGYHVFHIHDNQ 384
            ...:.:...|    :|.|.|.:||     |..|..|:       |.|::.||..|    ..::|.
 Frog   543 SSTSKQAAKP----VVSTTEPLPS-----TGSDSDAS-------PNKSKEGAEEG----EKNENN 587

  Fly   385 TGVE----------------IVKNSRNSVETLIHFELQNLRPYTDYRVIVKAFTT----KNEGEP 429
            .|.|                ...:|..|.|...|.|.......||......|..|    :..|..
 Frog   588 EGEEGDRDQDEEGEKESEKKEKSSSTRSSEVQNHTESTPTAVSTDKVAEAGANETITDPRQNGNT 652

  Fly   430 SDQIAQRTD------VGGPSAPAIVNLTCHSQESITIRWRRPYEFYNTIDFYIIKTRLAGQDTHR 488
            |....|.|.      ..|||.||:.::..:..:..|...|...:.|:.            .||..
 Frog   653 SLIEPQETKPSTPGATAGPSHPAVTSIEDYYVDLTTTMHRSRSKEYSE------------GDTEV 705

  Fly   489 DIRINASAKELETAMILQNLTTNSYYEVKVAAATFSVINPKKIVLGKFSESRIIQLQPNCEKLQP 553
            |||                               |..:||...:      :..:.:.|:..|::.
 Frog   706 DIR-------------------------------FFTVNPDPQI------NSSMAMWPHPGKMEW 733

  Fly   554 LLRQSHNDYNLAVLVGIIFSCFGIILIIMAFFLWSRKCFHAAYYYLDDPPHHPNAPQV--DWEVP 616
            ::       .|.|:..:.|.|   :::::|..::.||||..|::|::|    .::|:|  :..:|
 Frog   734 II-------PLVVVSALTFVC---LILLLAVLVYWRKCFQTAHFYVED----SSSPRVIPNESIP 784

  Fly   617 -VKIGDEIRAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECISD-DLPCEHSQHPENKRKNRY 679
             :.|.|::. |:||.:|.||::.|:::...|||.|:|.:| .|.|| ::..|||.||:||.||||
 Frog   785 IIPIPDDME-AIPVKQFIKHISELYSNNQHGFSEEFEEVQ-RCTSDMNITAEHSNHPDNKHKNRY 847

  Fly   680 LNITAYDHSRVHLHPTPGQ-KKNLDYINANFIDGYQKGHAFIGTQGPLPDTFDCFWRMIWEQRVA 743
            :||.|||||||.|.|.||: .|:.||||||::|||.|..|:|.|||||..||:.||||||||...
 Frog   848 INIVAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTG 912

  Fly   744 IIVMITNLVERGRRKCDMYWPKDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCN-- 806
            ||||||||||:||||||.|||.:..:.||.|.|.|....|.:.||||...|:::|:||.::.|
 Frog   913 IIVMITNLVEKGRRKCDQYWPTENSDEYGNIMVTLKSTRVYACYTVRKFTIRNMKMKKGQKGNAK 977

  Fly   807 ---TEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDA 868
               .|:.|.|||||.|||.|.|::.||||.||::|||....|.||::|||||||||||||||:|:
 Frog   978 GRHNERTVMQYHYTQWPDMGVPEYALPVLTFVRRSSAVQLPEMGPVLVHCSAGVGRTGTYIVIDS 1042

  Fly   869 MLKQIQQKNIVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVEELKN--C 931
            ||:||:.|:.||..|||:|||.|||:||||||||||:||||:|||...||.:.|.|:....|  .
 Frog  1043 MLQQIKDKSTVNALGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVCANQLHSYVNSIL 1107

  Fly   932 TP------YLEQQYKNIIQFQPKDIHIASAMKQVNSIKNR-GAIFPIEGSRVHLTPKPGEDGSDY 989
            ||      .||:|::.:.|...|.:...||.|..|..||| .::.|.|.:||.|.|.||..|:||
 Frog  1108 TPGPGGRTRLEKQFRLVTQCNAKYVECFSAQKDSNKEKNRNSSVVPSERARVGLAPLPGMKGTDY 1172

  Fly   990 INASWLHGFRRLRDFIVTQHPMAHTIKDFWQMVWDHNAQTVVLL---SSLDDINFAQFWPDEATP 1051
            ||||::.|:.|..:||:|||||.||.||||:|:||||||.:|:|   .||.:..|. :||.....
 Frog  1173 INASYIMGYLRSNEFIITQHPMPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFV-YWPSREES 1236

  Fly  1052 IESDHYRVKFLNK-----TNKSDYVSRDFVIQSIQDDYELTVKMLHCPSWPEMSNP-NSIYDFIV 1110
            :..:.:.|..::|     :|:...:..||::::.||||.|.|:...||.||....| :|.::.|.
 Frog  1237 MNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISSAFELIN 1301

  Fly  1111 DVHERCNDYRNGPIVIVDRYGGAQACTFCAISSLAIEMEYCSTANVYQYAKLYHNKRPGVWTSSE 1175
            .:.|.... |:||.::.|.:|...|.|.||:::|:.:||..:..:|||.||:.:..||||:|..|
 Frog  1302 VIKEEALT-RDGPTIVHDEFGAVSAGTLCALATLSQQMENENAVDVYQVAKMINLMRPGVFTDIE 1365

  Fly  1176 DIRVIY----NILSFLPGNLNL 1193
            ..:.:|    :::|......||
 Frog  1366 HYQFLYKAMLSLISTKENGTNL 1387

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	20/113 (18%)
		FN3	243..337	CDD:238020	16/116 (14%)
		fn3	343..430	CDD:394996	22/106 (21%)
		FN3	442..520	CDD:238020	12/77 (16%)
		R5-PTPc-1	704..907	CDD:350397	126/207 (61%)
		R5-PTP-2	989..1182	CDD:350398	77/205 (38%)
ptprg	XP_031757104.1	alpha_CARP_receptor_like	67..319	CDD:239396	28/147 (19%)
		FN3	349..426	CDD:214495	15/82 (18%)
		R-PTPc-G-1	815..1088	CDD:350505	166/273 (61%)
		R-PTP-G-2	1172..1376	CDD:350508	77/205 (38%)