DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp99A and ptpn23a

DIOPT Version :9

Sequence 1:	NP_651691.4	Gene:	Ptp99A / 43469	FlyBaseID:	FBgn0004369	Length:	1397	Species:	Drosophila melanogaster
Sequence 2:	XP_005158252.1	Gene:	ptpn23a / 100007322	ZFINID:	ZDB-GENE-100921-24	Length:	2003	Species:	Danio rerio

Alignment Length:	395	Identity:	97/395 - (24%)
Similarity:	179/395 - (45%)	Gaps:	51/395 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   613 WEVPVKIGDEIRAAVPVNEFAKHVASLHADGDIGFSREYEAIQNECISDDLPCEHSQHPENKR-- 675
            ::.|.::.   :.:..:..|...|.||......|...|.:|...|       .:..|..:.::
Zfish  1485 YQAPERVS---KLSAQLERFRSTVQSLERPTGEGGLSELDAQWKE-------LQEQQEKDTRQLS 1539

  Fly   676 ---------KNRYLNITAYDHSRVHLHPTPGQKKNLDYINANFIDGYQK-GHAFIGTQGPLPDTF 730
                     |||:.::..||.:||.||  .|:.   |||||:|.:.... ....|.||.||..|.
Zfish  1540 IAIARCYTMKNRHQDVMPYDCNRVVLH--SGKD---DYINASFTEDLSPYCPRLIATQAPLTGTA 1599

  Fly   731 DCFWRMIWEQRVAIIVMITNLVERGRRKCDMYWPKDGVE--TYGVIQVKLIEEEVMSTYTVRTLQ 793
            ..||.|::||:|::|||:.:..|..::|...|:|.:..:  ..|.|.:.|..::...|:..|.:.
Zfish  1600 ADFWLMVYEQKVSVIVMLVSEQELEKQKVLRYFPSERGQQLAQGPITLTLTTQKSTPTHIERMIG 1664

  Fly   794 IKHLKLKKKKQCNTEKLVYQYHYTNWPDHGTPDHPLPVLNFVKKSSA----ANPAEAGPIVVHCS 854
            :::      :..:..:.|....:|:||:.|.|:....::.|:::...    ..|... |:|||||
Zfish  1665 LQY------RDQSLRRTVVHLQFTSWPELGLPESKSNLIRFIQEVHGHYLLQRPLHT-PVVVHCS 1722

  Fly   855 AGVGRTGTYIVLDAMLKQIQQKN-IVNVFGFLRHIRAQRNFLVQTEEQYIFLHDALV---EAIAS 915
            :||||||.:.:|.|.|::|:..| |.::...:|.:|.||..::|.:....|.::|::   |.:..
Zfish  1723 SGVGRTGAFCLLYAALQEIEAGNGIPDLIQLVRKMRQQRKNMLQEKLHLKFCYEAVLKHTEQVLQ 1787

  Fly   916 GETNLMAEQVEELKNCTPYLEQQYKNIIQFQPKDIHIASAMKQVNSIKNRGAIFPIEGSRVHLTP 980
            ....:.:.......|.|      .|:..:.:.:||.:...| .::||:...|...|....|....
Zfish  1788 RHGIITSPCTRTPNNIT------LKSYSRQESQDIVLGGDM-PISSIQATVAKLSIRPPSVDHEQ 1845

  Fly   981 KPGED 985
            :|.:|
Zfish  1846 EPSQD 1850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020
		fn3	249..331	CDD:278470
		FN3	342..437	CDD:238020
		FN3	442..520	CDD:238020
		PTPc	646..911	CDD:214550	78/286 (27%)
		PTPc	676..911	CDD:238006	73/245 (30%)
		PTPc	935..1186	CDD:214550	11/51 (22%)
		PTPc	963..1169	CDD:238006	5/23 (22%)
ptpn23a	XP_005158252.1	BRO1_HD-PTP_like	2..357	CDD:185762
		V_HD-PTP_like	362..698	CDD:185747
		ALIX_LYPXL_bnd	416..701	CDD:290660
		Y_phosphatase	1548..1780	CDD:278528	73/243 (30%)
		PTPc	1549..1779	CDD:238006	73/241 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900