DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment stg and CDC25A

DIOPT Version :9

Sequence 1:	NP_001263066.1	Gene:	stg / 43466	FlyBaseID:	FBgn0003525	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_001780.2	Gene:	CDC25A / 993	HGNCID:	1725	Length:	524	Species:	Homo sapiens

Alignment Length:	467	Identity:	146/467 - (31%)
Similarity:	222/467 - (47%)	Gaps:	74/467 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NISNNTSSSSSI-NKMSGSRRARRSLELMSMDQEELSFYDDDVVPQDQ----QRSASPELMGLLS 76
            |:.|......|: .|:.|...|.:.....|:|.:.....|.|...:::    ::...|...|.|.
Human    97 NLENPMRRIHSLPQKLLGCSPALKRSHSDSLDHDIFQLIDPDENKENEAFEFKKPVRPVSRGCLH 161

  Fly    77 PEGSPQRFQIVRQ-PKILPAMGVSSDH----TPARSFRIFNSLSSTCSMESSMDDEYMELFEMES 136
            ..|..:...:..| ....||..:||:.    .|.....:|...|...:..|..||.:::|.:.|:
Human   162 SHGLQEGKDLFTQRQNSAPARMLSSNERDSSEPGNFIPLFTPQSPVTATLSDEDDGFVDLLDGEN 226

  Fly   137 --QSQQTALGFPSGLNSLISGQIKEQPAAKSPAGLSMRRPSV-RRCLSMTESNTNSTTTPPPKTP 198
              ..::|    ||.:.||.:            |.|.||..:: .||......:..|::|
Human   227 LKNEEET----PSCMASLWT------------APLVMRTTNLDNRCKLFDSPSLCSSST------ 269

  Fly   199 ETARDCFKRPE------PPASANCSPIQSKRHRCAAVEKENCPAPSPLSQVTISHPPPLRKCMSL 257
               |...||||      ||.|.     :.::....|..||:            ::|....:.:..
Human   270 ---RSVLKRPERSQEESPPGST-----KRRKSMSGASPKES------------TNPEKAHETLHQ 314

  Fly   258 NDAEIMSALARSEN--RNEP-ELIGDFSKAYALPLMEGRHRDLKSISSETVARLLKGEFSDKVAS 319
            :.:...|.....||  .|:| :|||||||.|....:.|:|:|||.||.|.:|.:|.|:|::.:..
Human   315 SLSLASSPKGTIENILDNDPRDLIGDFSKGYLFHTVAGKHQDLKYISPEIMASVLNGKFANLIKE 379

  Fly   320 YRIIDCRYPYEFEGGHIEGAKNLYTTEQILDEFLTVQQTELQQQQNAESGHKRNIIIFHCEFSSE 384
            :.|||||||||:|||||:||.||:..|::.|..|        ::....:..||.|::||||||||
Human   380 FVIIDCRYPYEYEGGHIKGAVNLHMEEEVEDFLL--------KKPIVPTDGKRVIVVFHCEFSSE 436

  Fly   385 RGPKMSRFLRNLDRERNTNAYPALHYPEIYLLHNGYKEFFESHVELCEPHAYRTMLDPAYNEAYR 449
            |||:|.|::|  :|:|..|.||.|||||:|:|..||||||......|||.:||.|....:.|..:
Human   437 RGPRMCRYVR--ERDRLGNEYPKLHYPELYVLKGGYKEFFMKCQSYCEPPSYRPMHHEDFKEDLK 499

  Fly   450 HFRAKSKSWNGD 461
            .||.||::|.|:
Human   500 KFRTKSRTWAGE 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stg	NP_001263066.1	Cdc25	297..425	CDD:238788	64/127 (50%)
CDC25A	NP_001780.2	Phosphodegron	74..84
		M-inducer_phosp	86..328	CDD:310900	53/272 (19%)
		KEN box	141..143		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	264..317		14/78 (18%)
		Cdc25	357..475	CDD:238788	64/127 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148392
Domainoid	1	1.000	114	1.000	Domainoid score	I6064
eggNOG	1	0.900	-	-		E1_COG5105
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	203	1.000	Inparanoid score	I3749
Isobase	1	0.950	-	0	Normalized mean entropy	S3967
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1423329at2759
OrthoFinder	1	1.000	-	-		FOG0000931
OrthoInspector	1	1.000	-	-		mtm8627
orthoMCL	1	0.900	-	-		OOG6_101194
Panther	1	1.100	-	-	LDO	PTHR10828
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R583
SonicParanoid	1	1.000	-	-		X695
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.740