DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stg and Cdc25b

DIOPT Version :9

Sequence 1:	NP_001263066.1	Gene:	stg / 43466	FlyBaseID:	FBgn0003525	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_598256.2	Gene:	Cdc25b / 171103	RGDID:	621500	Length:	575	Species:	Rattus norvegicus

Alignment Length:	460	Identity:	150/460 - (32%)
Similarity:	225/460 - (48%)	Gaps:	75/460 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NISNNTSSSSSINKMSGSRRARRSLELMSMDQEELSFYDDDVV---PQDQQRSASPELMGLLSPE 78
            ||:|:.:..|.....:|.|.|....|    |:|     :|..:   ||....|:|...:.    |
  Rat   163 NITNSQALDSWEKDEAGYRAASSPGE----DKE-----NDGYIFKMPQKLPHSSSARALA----E 214

  Fly    79 GSPQRFQIVRQPKILP---------AMGVSSDHTPARSFRIFNSLSSTCSMESSM--DDEYMELF 132
            .:.:|....::|...|         .|.|......|:|       ||...:|.:.  ||.::::.
  Rat   215 WASRREAFTQRPSSAPDLMCLTTDGKMDVEEASPVAQS-------SSLTPVERACEEDDGFVDIL 272

  Fly   133 EMESQSQQTALGFPSGLNSLISGQIKEQPAAKSPAGLSMRRPSVRRCLSMTESNTNSTTTPPPKT 197
            |.:.:.....   |:|:.:|||..:.::...:....|.|    ..:|..:..|         |..
  Rat   273 ESDLKDDDMV---PAGMENLISAPLVKKLDKEEEQDLIM----FSKCQRLFRS---------PSM 321

  Fly   198 P-ETARDCFKRPEPPASANCSPIQSKRHRCAAVEKENCPAPSPLSQVTISHPPPLRKCMSLNDAE 261
            | ...|...||.|.|...:. |:.|||.:          :.:||.:..:.. |..|...|.:...
  Rat   322 PCSVIRPILKRLERPHDRDV-PVLSKRRK----------SGTPLEEQQLEE-PKARVFRSKSLCH 374

  Fly   262 IMSALARSENRNEPELIGDFSKAYALPLMEGRHRDLKSISSETVARLLKGEFSDKVASYRIIDCR 326
            .:.::..|::|.   ||||:|||:.|..::|:|:|||.||.||:..||.|:||:.|..:.|:|||
  Rat   375 EIESILDSDHRG---LIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVEKFVIVDCR 436

  Fly   327 YPYEFEGGHIEGAKNLYTTEQILDEFLTVQQTELQQQQNAESGHKRNIIIFHCEFSSERGPKMSR 391
            ||||:|||||:.|.|| ..|...:.||      |:......:..||.|:||||||||||||:|.|
  Rat   437 YPYEYEGGHIKNAVNL-PLEPDAETFL------LKHPITPCNLDKRIILIFHCEFSSERGPRMCR 494

  Fly   392 FLRNLDRERNTNAYPALHYPEIYLLHNGYKEFFESHVELCEPHAYRTMLDPAYNEAYRHFRAKSK 456
            |:|  :|:|..|.||:|:|||:|:|..||||||..|...|||..||.|...|:.:..|:||.|::
  Rat   495 FIR--ERDRAANDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHAAFRDELRNFRLKTR 557

  Fly   457 SWNGD 461
            ||.|:
  Rat   558 SWAGE 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stg	NP_001263066.1	Cdc25	297..425	CDD:238788	67/127 (53%)
Cdc25b	NP_598256.2	M-inducer_phosp	111..378	CDD:399542	54/262 (21%)
Cdc25b	NP_598256.2	Cdc25	407..526	CDD:238788	67/127 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	114	1.000	Domainoid score	I5909
eggNOG	1	0.900	-	-		E1_COG5105
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	193	1.000	Inparanoid score	I3762
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1423329at2759
OrthoFinder	1	1.000	-	-		FOG0000931
OrthoInspector	1	1.000	-	-		mtm9106
orthoMCL	1	0.900	-	-		OOG6_101194
Panther	1	1.100	-	-	O	PTHR10828
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X695
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.870