DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stg and Cdc25a

DIOPT Version :9

Sequence 1:	NP_001263066.1	Gene:	stg / 43466	FlyBaseID:	FBgn0003525	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_598255.2	Gene:	Cdc25a / 171102	RGDID:	621498	Length:	525	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	158/479 - (32%)
Similarity:	230/479 - (48%)	Gaps:	74/479 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SSSSINKMSGSRRARRSL------ELMSMDQEELSFYDDDVVPQDQQRSASPELMGLLSPEGSPQ 82
            :|||:.:|..|.......      .|.|.:..|:|....:.:|| :....||.|....|......
  Rat    67 NSSSLQRMGSSESTDSGFCLDSPGPLDSKENLEISLRRINCLPQ-KLLGCSPALKRSHSDSLDHD 130

  Fly    83 RFQIVRQPK------------ILPA-MGVSSDHTPARSFRIF--NSLSSTCSMESSMDDEYME-- 130
            .||::.|.:            |.|| .|..:.|....|...|  ...|:...|.||.:.:..|
  Rat   131 IFQLIDQDENKENEAFEFKKPIRPASRGCLNAHVHEESKDPFTHRQNSAPARMLSSNESDISESG 195

  Fly   131 ----LFEMESQSQQTALGFPSGLNSLISGQ----IKEQPAAKS---PAGLSMRRPS--VRRCLSM 182
                ||..:|..:.|......|...|:.|:    .:|.|:..|   .|.|.||||:  ..||
  Rat   196 NFSPLFTPQSPVKATLSDEDDGFIDLLDGENLKNDEETPSCMSSLWTAPLVMRRPTNLADRC--- 257

  Fly   183 TESNTNSTTTPPPKTPETARDCFKRPEPPASANCSPIQSKRHRC--AAVEKENCPAPSPLSQVTI 245
               ....:.:|...|...:....||.:  .|...||..:||.:.  |:..|.:.|.|:.|...::
  Rat   258 ---GLFDSPSPCSSTSSCSTRAVKRAD--RSHEESPRGTKRRKSSEASPVKADVPEPTQLPHQSL 317

  Fly   246 SHPPPLRKCMSLNDAEIMSALARSENRNEPELIGDFSKAYALPLMEGRHRDLKSISSETVARLLK 310
            |       ..|.....|.:.|    :.:..:|||||||.|....:.|:|:|||.||.|.:|.:|.
  Rat   318 S-------LTSFPKGTIENIL----DSDPRDLIGDFSKGYLFHTVSGKHQDLKYISPEIMASVLN 371

  Fly   311 GEFSDKVASYRIIDCRYPYEFEGGHIEGAKNLYTTEQILDEFLTVQQTELQQQQNAESGHKRNII 375
            |:|::.:..:.|||||||||:|||||:||.||:..|:: :|||.       ::....:..||.|:
  Rat   372 GKFANLIKEFVIIDCRYPYEYEGGHIKGAVNLHMEEEV-EEFLL-------KKPIVPADGKRVIV 428

  Fly   376 IFHCEFSSERGPKMSRFLRNLDRERNTNAYPALHYPEIYLLHNGYKEFF---ESHVELCEPHAYR 437
            :|||||||||||:|.|::|  :|:|..|.||.|||||:|:|..||||||   :||   |||.:||
  Rat   429 VFHCEFSSERGPRMCRYVR--ERDRLGNEYPKLHYPELYVLKGGYKEFFLKCQSH---CEPPSYR 488

  Fly   438 TMLDPAYNEAYRHFRAKSKSWNGD 461
            .|....:.|..:.||.||::|.|:
  Rat   489 PMHHEDFKEDLKKFRTKSRTWAGE 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stg	NP_001263066.1	Cdc25	297..425	CDD:238788	66/130 (51%)
Cdc25a	NP_598255.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42
		Phosphodegron	74..84		2/9 (22%)
		M-inducer_phosp	86..329	CDD:399542	60/258 (23%)
		KEN box	141..143		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..318		14/59 (24%)
		Cdc25	358..475	CDD:238788	64/126 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342302
Domainoid	1	1.000	114	1.000	Domainoid score	I5909
eggNOG	1	0.900	-	-		E1_COG5105
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	193	1.000	Inparanoid score	I3762
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1423329at2759
OrthoFinder	1	1.000	-	-		FOG0000931
OrthoInspector	1	1.000	-	-		mtm9106
orthoMCL	1	0.900	-	-		OOG6_101194
Panther	1	1.100	-	-	LDO	PTHR10828
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X695
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760