Protein Alignment CG11951 and NPEPPS

DIOPT Version :10

• Sequence 1: NP_001350853.2
• Gene: CG11951 / 43463
• FlyBaseID: FBgn0039656
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_001398059.1
• Gene: NPEPPS / 9520
• HGNCID: 7900
• Length: 924
• Species: Homo sapiens
• Alignment Length: 859
• Identity: 277/859 - (32%)
• Similarity: 427/859 - (49%)
• Gaps: 69/859 - (8%)

  Fly     8 LAALGLSFAGEGSTYDHFRLPTALRPQSYDVRILTQLENPD--DFHFNGTVKIQIEVLQNTHNIT 70
            |.:|||:...|...::  |||..:.|.:|.:.:     .||  ||.|.|.::...:|.|.|:.|.
Human    37 LHSLGLAAMPEKRPFE--RLPADVSPINYSLCL-----KPDLLDFTFEGKLEAAAQVRQATNQIV 94

  Fly    71 LHSKDLTIDDTEITLSQI--GGEETTENCITSTAVN-PTHDFYILNTCKELLAGQFYELSLPFSA 132
            ::..|:.|    ||.|..  |.||     |.:|..| ...|..:..:....|......|.:.|..
Human    95 MNCADIDI----ITASYAPEGDEE-----IHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVG 150

  Fly   133 KLQDQLAGYYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLS 197
            :|.|::.|:|||.| .|.:.|.|:.:|||||...||.||||:|||..||:|.|:|...|....||
Human   151 ELNDKMKGFYRSKY-TTPSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALS 214

  Fly   198 NMPVNETRPHESIPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAIDQCD 262
            ||.|.:.:|:....:.|...|..:..|||||||:.:.::....:...:|...|.:......:|..
Human   215 NMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGK 279

  Fly   263 YAAELGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQ 327
            :|.|:..|.|.:|::.|.:.:||||:|.||:.||:|||||||||||:.|:.||..|:.|...::|
Human   280 FALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQ 344

  Fly   328 ETANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLLTIFR 392
            ..|.:|.||||||||||||||:|||.||||||||:::..|||:...|::........::......
Human   345 WVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQE 409

  Fly   393 KDSLESSHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAE 457
            .|:|::||||...:...|::.|.||.|||.||:|||||:|.::|::.|:.|:..||.|:..|||.
Human   410 LDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAA 474

  Fly   458 QDNLWESLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYT--SRTAKLSQERYLLNTD 520
            .::|||||..|:.|.        |..:|::||.|.|:|:|.|..:..  .|..:|||:::....
Human   475 TEDLWESLENASGKP--------IAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAGG- 530

  Fly   521 VSRAHKGC--WWVPLSYTNQEEKDFNNTAPKEWMECTETGESVPKTIHDLPGPDQWVIFNNQLSA 583
             |...:.|  |.||::.:..|  |.|....|..|:..|. ..|.|.:.    |||||..|.....
Human   531 -SYVGEDCPQWMVPITISTSE--DPNQAKLKILMDKPEM-NVVLKNVK----PDQWVKLNLGTVG 587

  Fly   584 PYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLEREREL 648
            .|:..|.:...:.|:..:..   .|:..|:|..|.:|:...|..|.......|:|:.....|...
Human   588 FYRTQYSSAMLESLLPGIRD---LSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNY 649

  Fly   649 LPWKSAFDNLQFVSGILRQTPNFRFFKNFTRRLITPIYEHLNGINDTVASEEQQDKTILKAIV-- 711
            ..|.....||..:|.:|..|..:...:.|.:.:.:||.|.|..  |....|...| .:|:.:|
Human   650 TVWSDLSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLGW--DPKPGEGHLD-ALLRGLVLG 711

  Fly   712 ----ADWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGCDEDWDFLWT 772
                |....:.|.:         .|.::......::  :...:|..||.|.:|||.....|.:..
Human   712 KLGKAGHKATLEEA---------RRRFKDHVEGKQI--LSADLRSPVYLTVLKHGDGTTLDIMLK 765

  Fly   773 RYQKANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIA-DSEVGFLLAK 836
            .:::|::..||..|...||.:....::|:.|  .|....::|.||:.||...:| .|:.|...|.
Human   766 LHKQADMQEEKNRIERVLGATLLPDLIQKVL--TFALSEEVRPQDTVSVIGGVAGGSKHGRKAAW 828

  Fly   837 KYLMDNVDSISKFY 850
            |::.||.:.:...|
Human   829 KFIKDNWEELYNRY 842

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	177/459 (39%)
		ERAP1_C	574..902	CDD:463368	65/284 (23%)
NPEPPS	NP_001398059.1	M1_APN-Q_like	61..499	CDD:341064	177/460 (38%)
		ERAP1_C	578..854	CDD:463368	65/284 (23%)
		Nuclear localization signal. /evidence=ECO:0000255	726..730		1/3 (33%)