Protein Alignment CG11951 and AAP1

DIOPT Version :10

• Sequence 1: NP_001350853.2
• Gene: CG11951 / 43463
• FlyBaseID: FBgn0039656
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_011913.1
• Gene: AAP1 / 856443
• SGDID: S000001089
• Length: 856
• Species: Saccharomyces cerevisiae
• Alignment Length: 927
• Identity: 285/927 - (30%)
• Similarity: 442/927 - (47%)
• Gaps: 110/927 - (11%)

  Fly    27 LPTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVLQNTHNI-TLHSKDLTIDDTEITLSQIGG 90
            ||..:.|..||:   |...|...|.|.|::||.:::  |.|:| ::....|.||.....:..:..
Yeast     6 LPNNVTPLHYDI---TLEPNFRAFTFEGSLKIDLQI--NDHSINSVQINYLEIDFHSARIEGVNA 65

  Fly    91 EET--TENCITSTAVNPTHDFYILNTCKELLAGQFYELSLPFSAKLQDQLAGYYRSSYVNTVANE 153
            .|.  .||...:|.|.|...|..|        |...:|.:.||..|.||:||:||:.|.:.|..|
Yeast    66 IEVNKNENQQKATLVFPNGTFENL--------GPSAKLEIIFSGILNDQMAGFYRAKYTDKVTGE 122

  Fly   154 TRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNETRPHESIPD-YVWTS 217
            |::::.||.|...||.||||||||..||:||:||......|.||||.|.    :|:|.: ..:|:
Yeast   123 TKYMATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTHLSNMDVR----NETIKEGKKYTT 183

  Fly   218 FEESLPMSTYLVAYSLNDFSHKPST---LPNGTLFRTWARPNAIDQCDYAAELGPKVLKYYEELF 279
            |..:..|||||||:.:.|..:..|.   :|    .|.::.|.......:||.|..:.|:::|:.|
Yeast   184 FNTTPKMSTYLVAFIVADLRYVESNNFRIP----VRVYSTPGDEKFGQFAANLAARTLRFFEDTF 244

  Fly   280 GIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANIVAHELAHQWFGN 344
            .|::||||:|.:||.:|||||||||||||:....||...|.||.:..|..|.::.||||||||||
Yeast   245 NIEYPLPKMDMVAVHEFSAGAMENWGLVTYRVIDLLLDIENSSLDRIQRVAEVIQHELAHQWFGN 309

  Fly   345 LVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLLTIFRKDSLESSHPISRPIEMT 409
            ||||.||..|||||||||:::........|:|:..:.....||......|||.|||||..|:...
Yeast   310 LVTMDWWEGLWLNEGFATWMSWYSCNKFQPEWKVWEQYVTDNLQRALNLDSLRSSHPIEVPVNNA 374

  Fly   410 SQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQDNLWESLTQAAHKTGS 474
            .:|::.||.|||.||||::||:..:||||.|..|:..||.|:.|.||:..:||::|..|:.|
Yeast   375 DEINQIFDAISYSKGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTGDLWDALADASGK--- 436

  Fly   475 LPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNTDVSRAHKGCWWVPLSYTNQE 539
                 ::.::|:.||.:.|:||::|.......|  |:|.|||...||                :|
Yeast   437 -----DVCSVMNIWTKRVGFPVLSVKEHKNKIT--LTQHRYLSTGDV----------------KE 478

  Fly   540 EKDFNNTAPKEWMECTETGESVPKTIHDLPGPDQWVIFNNQLSAP--------YKVN-------- 588
            |:|             .|...:...:.|..|.|..::.|.: ||.        :|:|
Yeast   479 EED-------------TTIYPILLALKDSTGIDNTLVLNEK-SATFELKNEEFFKINGDQSGIFI 529

  Fly   589 --YDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLERERELLPW 651
              |..:.|..|     |:..:.:.|.:|..|:.|....:.:|.......|.:||..:.|...:.|
Yeast   530 TSYSDERWAKL-----SKQANLLSVEDRVGLVADAKALSASGYTSTTNFLNLISNWKNEDSFVVW 589

  Fly   652 KSAFDNLQFVSG--ILRQTPNFRFFKNFTRRLITPIYEHLN---GINDTVASEEQQDKTILKAIV 711
            :...::|..:..  :............||..|:......|.   |.:|:.|.:.      ||..:
Yeast   590 EQIINSLSALKSTWVFEPEDILNALDKFTLDLVLNKLSELGWNIGEDDSFAIQR------LKVTL 648

  Fly   712 ADWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGCDEDWDFLWTRYQK 776
            ...||:.......:.|:..:..:   ||.:: ..:|...:.||:.|..:.|.:.:::.::..||.
Yeast   649 FSAACTSGNEKMQSIAVEMFEEY---ANGNK-QAIPALFKAVVFNTVARLGGENNYEKIFNIYQN 709

  Fly   777 ANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIADSEVGFLLAKKYLMD 841
            ...:.||.|.|.:||..::..:|:|.|....|  |.:..||.....|.|...:.|......::.:
Yeast   710 PVSSEEKIIALRALGRFEDKELLERTLSYLLD--GTVLNQDFYIPMQGIRVHKKGIERLWAWMQE 772

  Fly   842 NVDSISKFYHPQSESMSELLPPLSEQIFTQRDYDEFMNFMASSKDQLKDIEQTISQSLETMLINV 906
            :.|.|:|...|.|..:..:| .|....||..:..|.::...|.| ..|..:||::|:|:|:....
Yeast   773 HWDEIAKRLQPGSPVLGGVL-TLGLTNFTSFEALEKISAFYSRK-VTKGFDQTLAQALDTIRSKA 835

  Fly   907 QWKERNYERFTRAISKH 923
            ||..|:.|.....:.:|
Yeast   836 QWVSRDREIVATYLREH 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	182/461 (39%)
		ERAP1_C	574..902	CDD:463368	74/350 (21%)
AAP1	NP_011913.1	M1_APN-Q_like	13..447	CDD:341064	182/462 (39%)
		ERAP1_C	517..833	CDD:463368	72/334 (22%)