DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and AAP1

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_011913.1	Gene:	AAP1 / 856443	SGDID:	S000001089	Length:	856	Species:	Saccharomyces cerevisiae

Alignment Length:	927	Identity:	285/927 - (30%)
Similarity:	442/927 - (47%)	Gaps:	110/927 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LPTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVLQNTHNI-TLHSKDLTIDDTEITLSQIGG 90
            ||..:.|..||:   |...|...|.|.|::||.:::  |.|:| ::....|.||.....:..:..
Yeast     6 LPNNVTPLHYDI---TLEPNFRAFTFEGSLKIDLQI--NDHSINSVQINYLEIDFHSARIEGVNA 65

  Fly    91 EET--TENCITSTAVNPTHDFYILNTCKELLAGQFYELSLPFSAKLQDQLAGYYRSSYVNTVANE 153
            .|.  .||...:|.|.|...|..|        |...:|.:.||..|.||:||:||:.|.:.|..|
Yeast    66 IEVNKNENQQKATLVFPNGTFENL--------GPSAKLEIIFSGILNDQMAGFYRAKYTDKVTGE 122

  Fly   154 TRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNETRPHESIPD-YVWTS 217
            |::::.||.|...||.||||||||..||:||:||......|.||||.|.    :|:|.: ..:|:
Yeast   123 TKYMATTQMEATDARRAFPCFDEPNLKATFAVTLVSESFLTHLSNMDVR----NETIKEGKKYTT 183

  Fly   218 FEESLPMSTYLVAYSLNDFSHKPST---LPNGTLFRTWARPNAIDQCDYAAELGPKVLKYYEELF 279
            |..:..|||||||:.:.|..:..|.   :|    .|.::.|.......:||.|..:.|:::|:.|
Yeast   184 FNTTPKMSTYLVAFIVADLRYVESNNFRIP----VRVYSTPGDEKFGQFAANLAARTLRFFEDTF 244

  Fly   280 GIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANIVAHELAHQWFGN 344
            .|::||||:|.:||.:|||||||||||||:....||...|.||.:..|..|.::.||||||||||
Yeast   245 NIEYPLPKMDMVAVHEFSAGAMENWGLVTYRVIDLLLDIENSSLDRIQRVAEVIQHELAHQWFGN 309

  Fly   345 LVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLLTIFRKDSLESSHPISRPIEMT 409
            ||||.||..|||||||||:::........|:|:..:.....||......|||.|||||..|:...
Yeast   310 LVTMDWWEGLWLNEGFATWMSWYSCNKFQPEWKVWEQYVTDNLQRALNLDSLRSSHPIEVPVNNA 374

  Fly   410 SQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQDNLWESLTQAAHKTGS 474
            .:|::.||.|||.||||::||:..:||||.|..|:..||.|:.|.||:..:||::|..|:.|
Yeast   375 DEINQIFDAISYSKGSSLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTGDLWDALADASGK--- 436

  Fly   475 LPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNTDVSRAHKGCWWVPLSYTNQE 539
                 ::.::|:.||.:.|:||::|.......|  |:|.|||...||                :|
Yeast   437 -----DVCSVMNIWTKRVGFPVLSVKEHKNKIT--LTQHRYLSTGDV----------------KE 478

  Fly   540 EKDFNNTAPKEWMECTETGESVPKTIHDLPGPDQWVIFNNQLSAP--------YKVN-------- 588
            |:|             .|...:...:.|..|.|..::.|.: ||.        :|:|
Yeast   479 EED-------------TTIYPILLALKDSTGIDNTLVLNEK-SATFELKNEEFFKINGDQSGIFI 529

  Fly   589 --YDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLERERELLPW 651
              |..:.|..|     |:..:.:.|.:|..|:.|....:.:|.......|.:||..:.|...:.|
Yeast   530 TSYSDERWAKL-----SKQANLLSVEDRVGLVADAKALSASGYTSTTNFLNLISNWKNEDSFVVW 589

  Fly   652 KSAFDNLQFVSG--ILRQTPNFRFFKNFTRRLITPIYEHLN---GINDTVASEEQQDKTILKAIV 711
            :...::|..:..  :............||..|:......|.   |.:|:.|.:.      ||..:
Yeast   590 EQIINSLSALKSTWVFEPEDILNALDKFTLDLVLNKLSELGWNIGEDDSFAIQR------LKVTL 648

  Fly   712 ADWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGCDEDWDFLWTRYQK 776
            ...||:.......:.|:..:..:   ||.:: ..:|...:.||:.|..:.|.:.:::.::..||.
Yeast   649 FSAACTSGNEKMQSIAVEMFEEY---ANGNK-QAIPALFKAVVFNTVARLGGENNYEKIFNIYQN 709

  Fly   777 ANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIADSEVGFLLAKKYLMD 841
            ...:.||.|.|.:||..::..:|:|.|....|  |.:..||.....|.|...:.|......::.:
Yeast   710 PVSSEEKIIALRALGRFEDKELLERTLSYLLD--GTVLNQDFYIPMQGIRVHKKGIERLWAWMQE 772

  Fly   842 NVDSISKFYHPQSESMSELLPPLSEQIFTQRDYDEFMNFMASSKDQLKDIEQTISQSLETMLINV 906
            :.|.|:|...|.|..:..:| .|....||..:..|.::...|.| ..|..:||::|:|:|:....
Yeast   773 HWDEIAKRLQPGSPVLGGVL-TLGLTNFTSFEALEKISAFYSRK-VTKGFDQTLAQALDTIRSKA 835

  Fly   907 QWKERNYERFTRAISKH 923
            ||..|:.|.....:.:|
Yeast   836 QWVSRDREIVATYLREH 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	182/461 (39%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	74/350 (21%)
AAP1	NP_011913.1	PepN	2..844	CDD:223385	283/917 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
TreeFam	0	0.000	Not matched by this tool.
	4	4.010