Protein Alignment CG11951 and APE2

DIOPT Version :10

• Sequence 1: NP_001350853.2
• Gene: CG11951 / 43463
• FlyBaseID: FBgn0039656
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_012765.3
• Gene: APE2 / 853699
• SGDID: S000001640
• Length: 952
• Species: Saccharomyces cerevisiae
• Alignment Length: 917
• Identity: 285/917 - (31%)
• Similarity: 441/917 - (48%)
• Gaps: 111/917 - (12%)

  Fly    27 LPTALRPQSYDVRILTQLENPD--DFHFNGTVKIQIEVLQNTHNITLHSKDLTIDDTEITLSQIG 89
            ||..:.|..||:.:     .||  .|.|.|:|||::::    :|..:.:..|...||:|..::|
Yeast   102 LPDNVVPLHYDLTV-----EPDFKTFKFEGSVKIELKI----NNPAIDTVTLNTVDTDIHSAKI- 156

  Fly    90 GEETTENCITSTAVNPTHDFYILNTCKELLAGQFYELSLPFSAKLQDQLAGYYRSSYVNTVANET 154
            |:.|:...|:......|...:...|........|  |.:.|:..|.|.:||:||:.|.:.:..||
Yeast   157 GDVTSSEIISEEEQQVTTFAFPKGTMSSFKGNAF--LDIKFTGILNDNMAGFYRAKYEDKLTGET 219

  Fly   155 RWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNETRPHESIPDYV----- 214
            ::::.||.||..||.||||||||..||||||||......|.||||.|..        :||
Yeast   220 KYMATTQMEPTDARRAFPCFDEPNLKASFAITLVSDPSLTHLSNMDVKN--------EYVKDGKK 276

  Fly   215 WTSFEESLPMSTYLVAYSLNDFSH---KPSTLPNGTLFRTWARPNAIDQCDYAAELGPKVLKYYE 276
            .|.|..:..|||||||:.:.:..:   |...:|    .|.:|.|.......:||:|..|.|.::|
Yeast   277 VTLFNTTPKMSTYLVAFIVAELKYVESKNFRIP----VRVYATPGNEKHGQFAADLTAKTLAFFE 337

  Fly   277 ELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANIVAHELAHQW 341
            :.|||::||||:|.:||.:|||||||||||||:....||...:.|:.:..|..|.:|.|||||||
Yeast   338 KTFGIQYPLPKMDNVAVHEFSAGAMENWGLVTYRVVDLLLDKDNSTLDRIQRVAEVVQHELAHQW 402

  Fly   342 FGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLLTIFRKDSLESSHPISRPI 406
            |||||||.||..|||||||||:::.....:..|:|:..:......|......|||.|||||..|:
Yeast   403 FGNLVTMDWWEGLWLNEGFATWMSWYSCNEFQPEWKVWEQYVTDTLQHALSLDSLRSSHPIEVPV 467

  Fly   407 EMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQDNLWESLTQAAHK 471
            :...:|::.||.|||.||:|::||:..:||||.|..|:..||.|:.|.||:.::||::|..|:.|
Yeast   468 KKADEINQIFDAISYSKGASLLRMISKWLGEETFIKGVSQYLNKFKYGNAKTEDLWDALADASGK 532

  Fly   472 TGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNTDVSRAHKGCWWVPLSYT 536
                    :::::|:.||.:.|:|||:|:.|...:.. ..|.|||...||.
Yeast   533 --------DVRSVMNIWTKKVGFPVISVSEDGNGKIT-FRQNRYLSTADVK-------------- 574

  Fly   537 NQEEKD----FNNTAPKEWMECTETGESVPKTIHDLPGPDQWVIFNNQLSAPYKVNYDAQNWKLL 597
            ..|:|.    |.....|..::.:.......||| :|..|..:.: |::.|..|..:|..:.|..|
Yeast   575 PDEDKTIYPVFLALKTKNGVDSSVVLSERSKTI-ELEDPTFFKV-NSEQSGIYITSYTDERWAKL 637

  Fly   598 ---IETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLERERELLPWKSAFDNLQ 659
               .:.|:.||        |..|:.||...:.:|.......|.::|....|:..:.|.      |
Yeast   638 GQQADLLSVED--------RVGLVADVKTLSASGYTSTTNFLNLVSKWNNEKSFVVWD------Q 688

  Fly   660 FVSGILRQTPNFRF--------FKNFTRRLITPIYEHLN---GINDTVASEEQQDKTILKAIVAD 713
            .::.|......:.|        ..|||::||:.:..||.   ..:|:.:::.      ||..:..
Yeast   689 IINSISSMKSTWLFEPKETQDALDNFTKQLISGMTHHLGWEFKSSDSFSTQR------LKVTMFG 747

  Fly   714 WACSFEVSDCVTQALSF---YRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGCDEDWDFLWTRYQ 775
            .||:...:|....||..   |.|...||       :|..|:.:|:.|..:.|..|:::.::..|.
Yeast   748 AACAARDADVEKAALKMFTDYCSGNKEA-------IPALIKPIVFNTVARVGGAENYEKVYKIYL 805

  Fly   776 KANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIADSEVGFLLAKKYLM 840
            ......||...|.|||..:|..:|:|.|...||  |.:..||.....|.:...:.|......::.
Yeast   806 DPISNDEKLAALRSLGRFKEPKLLERTLGYLFD--GTVLNQDIYIPMQGMRAHQEGVEALWNWVK 868

  Fly   841 DNVDSISKFYHPQSESMSELLPPLSEQIFTQRDYDEFMNFMASSKDQLKDIEQTISQSLETMLIN 905
            .|.|.:.|...|....:..::...:....:.:..||...|.|:.  ..|..:|:::|||:|:...
Yeast   869 KNWDELVKRLPPGLSMLGSVVTLGTSGFTSMQKIDEIKKFFATK--STKGFDQSLAQSLDTITSK 931

  Fly   906 VQWKERN 912
            .||..|:
Yeast   932 AQWVNRD 938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	179/464 (39%)
		ERAP1_C	574..902	CDD:463368	77/344 (22%)
APE2	NP_012765.3	M1_APN-Q_like	109..543	CDD:341064	179/465 (38%)
		ERAP1_C	614..928	CDD:463368	77/345 (22%)