DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and APM1

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_195035.2	Gene:	APM1 / 829446	AraportID:	AT4G33090	Length:	879	Species:	Arabidopsis thaliana

Alignment Length:	956	Identity:	292/956 - (30%)
Similarity:	469/956 - (49%)	Gaps:	127/956 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FAGEGSTYDHFRLPTALRPQSYDVRILTQLENPD--DFHFNGTVKIQIEVLQNTHNITLHSKDLT 77
            |.||.      |||....|:.||:|:     |||  ...|.|||.|.::::.:|..|.|::.||:
plant     4 FKGEP------RLPKFAVPKRYDLRL-----NPDLIACTFTGTVAIDLDIVADTRFIVLNAADLS 57

  Fly    78 IDDTEITLSQIGGEETTENCITSTAVNPTHDFYILNTCKELLAGQFYE--------LSLPFSAKL 134
            ::|..::.:    ..::...:.:..|       :|....|:|..:|.|        |.|.|:..|
plant    58 VNDASVSFT----PPSSSKALAAPKV-------VLFEEDEILVLEFGEILPHGVGVLKLGFNGVL 111

  Fly   135 QDQLAGYYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNM 199
            .|::.|:|||:|.:.  .|.:.::|||||||.||..|||:|||..||:|.|||........||||
plant   112 NDKMKGFYRSTYEHN--GEKKNMAVTQFEPADARRCFPCWDEPACKATFKITLEVPTDLVALSNM 174

  Fly   200 PVNETRPHESIPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAIDQCDYA 264
            |:.|.:.:.::.   ..|::||..|||||||..:..|.:......:|...|.:.:....||..:|
plant   175 PIMEEKVNGNLK---IVSYQESPIMSTYLVAIVVGLFDYVEDHTSDGIKVRVYCQVGKADQGKFA 236

  Fly   265 AELGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQET 329
            ..:|.|.|..::|.|.:.:||||:|.||:|||:||||||:||||:.|:.|||..::|:...||..
plant   237 LHVGAKTLDLFKEYFAVPYPLPKMDMIAIPDFAAGAMENYGLVTYRETALLYDEQHSAASNKQRV 301

  Fly   330 ANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWR--TLQLESMSNLLTIFR 392
            |.:||||||||||||||||:|||.|||||||||:|:.|..:.:.|:|:  |..|:..:..|   |
plant   302 ATVVAHELAHQWFGNLVTMEWWTHLWLNEGFATWVSYLATDSLFPEWKIWTQFLDESTEGL---R 363

  Fly   393 KDSLESSHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAE 457
            .|.||.||||...:...::|.|.||.|||:||:|||||:..:||.|.|:..|.:|::.:.|.||:
plant   364 LDGLEESHPIEVEVNHAAEIDEIFDAISYRKGASVIRMLQSYLGAEVFQKSLAAYIKNHAYSNAK 428

  Fly   458 QDNLWESLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNTDVS 522
            .::||     ||.:.||   ...:..:|.|||.|.||||  |:........:|.|.|:|.:   .
plant   429 TEDLW-----AALEAGS---GEPVNKLMSSWTKQKGYPV--VSAKIKDGKLELEQSRFLSS---G 480

  Fly   523 RAHKGCWWVPL-----SYTNQEEKDFNNTAP------KEWMECTETGESVPKTIHDLPGPDQWVI 576
            ...:|.|.||:     ||  ::.|:|...:.      ||.:.|     |:......:.|...|:.
plant   481 SPGEGQWIVPVTLCCGSY--EKRKNFLLESKSGAYDLKELLGC-----SIADGSDKINGTCSWIK 538

  Fly   577 FNNQLSAPYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISY 641
            .|...:..|:|.||.   .|.....|:.:..|:..::|..::||........:|.....|.:.|.
plant   539 INVDQAGFYRVKYDD---SLAAGLRNATESQSLTSIDRYGILDDSFALTMARQQSLASLLTLCSA 600

  Fly   642 LERERELLPWKSAFDNLQFVSGILRQTPNFRFFK---NFTRRLITPIYEHLNGINDTVASE---- 699
            .::|.:.    :...||..:|        ::..|   :..:.|::.|.....|:....|.:
plant   601 YKKELDY----TVLSNLIAIS--------YKVVKIGADANQELMSGIKHFFIGVFQFAAGKLGWD 653

  Fly   700 ----EQQDKTILKAIVADWACSFEVSDCVTQALSFYRSWRSEANPDEVNP-VPLGIRGVVYCTAI 759
                |.....:|:..|......|...:.:.:|:..:.::.::.|    .| :|..||...|...:
plant   654 PKQGESHLDAMLRGEVLTALAVFGHDETLKEAVRRFDAFLADRN----TPLLPPDIRRAAYVAVM 714

  Fly   760 KHGCDED---WDFLWTRYQKANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSV 821
            :.....|   ::.|...|::.:::.||..||.||....:..::|..|  ||....::|.||:...
plant   715 QRANKSDKSGYESLLRVYRETDLSQEKTRILGSLASCPDPTIVQDVL--NFVLSDEVRNQDALYG 777

  Fly   822 FQAIADSEVGFLLAKKYLMDNVDSISKFYHPQ---SESMSELLPPLSEQIFTQ-RDYDEFMNFMA 882
            ...:  |..|..:|.|:|.:..:.|...:...   :..:|.::.|.:.  |.: ::.:||  |..
plant   778 LSGV--SWEGREVAWKWLQEKWEYIGNTWGSGFLITRFISAVVSPFAS--FEKAKEVEEF--FAT 836

  Fly   883 SSKDQLKDIEQTISQSLETMLINVQW-----KERNYERFTRAISKH 923
            .||..:   .:|:.||:|.:.||..|     ||.|..:....:|.:
plant   837 RSKPSM---ARTLKQSIERVHINANWVESIKKEDNLTQLVAQLSSN 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	185/466 (40%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	69/346 (20%)
APM1	NP_195035.2	M1_APN-Q_like	18..453	CDD:341064	185/466 (40%)
APM1	NP_195035.2	ERAP1_C	536..855	CDD:403137	69/348 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020