DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11951 and Erap1

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_109636.1	Gene:	Erap1 / 80898	MGIID:	1933403	Length:	930	Species:	Mus musculus

Alignment Length:	951	Identity:	305/951 - (32%)
Similarity:	489/951 - (51%)	Gaps:	104/951 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GEGSTYDHFRLPTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVLQNTHNITLHSKDLTIDDT 81
            |:...:::.|||..:.|..||:.|...|..   ..|.|..:::|...:.|..|.:||..|.|  :
Mouse    33 GDSFPWNNMRLPEYMTPIHYDLMIHANLST---LTFWGKTEVEIIASRPTSTIIMHSHHLQI--S 92

  Fly    82 EITLSQIGGEETTENCITSTAVNPTHDFYILNTCKELLAGQFYELSLPFSAKLQDQLAGYYRSSY 146
            :.||.:..||..:|..: .....|.|:...|...:.||||..|.:.:.::|.|.:...|:|:|:|
Mouse    93 KATLRRGAGEMLSEEPL-KVLEYPAHEQVALLAAQPLLAGSLYTVIIDYAANLSESFHGFYKSTY 156

  Fly   147 VNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMP-VNETRPHES- 209
             .|...|.|.::.|||||.|||:||||||||..||||:|.:....::..:|||| |......|.
Mouse   157 -RTQEGEMRILAATQFEPTAARMAFPCFDEPALKASFSIKIKRDPRHLAISNMPLVKSVNVAEGL 220

  Fly   210 IPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAIDQCDYAAELGPKVLKY 274
            |.|:    |:.::.|||||||:.::||........:|.....:|.|:.|:|.|||.:....:|::
Mouse   221 IEDH----FDITVKMSTYLVAFIISDFKSVSKMTKSGVKVSVYAVPDKINQADYALDAAVTLLEF 281

  Fly   275 YEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANIVAHELAH 339
            ||:.|.|.:||||.|..|:|||.:||||||||.|:.||:|||..|.||..:|.....||:|||||
Mouse   282 YEDYFNIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESSLLYDKEKSSASSKLGITMIVSHELAH 346

  Fly   340 QWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLES--MSNLLTIFRKDSLESSHPI 402
            |||||||||:||.|||||||||.::..:.|...||:   |::|.  ..........|:|.||||:
Mouse   347 QWFGNLVTMEWWNDLWLNEGFAKFMEFVSVTVTHPE---LKVEDYFFGKCFNAMEVDALNSSHPV 408

  Fly   403 SRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQDNLWESLTQ 467
            |.|:|..:||.|.||::||:||:.::.|:..:|..:.|:.|:..||:||:|||.:.::||.|:..
Mouse   409 STPVENPAQIREMFDDVSYEKGACILNMLRDYLSADTFKRGIVQYLQKYSYKNTKNEDLWNSMMH 473

  Fly   468 AAHKTGSLPKD-------------------YNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQE 513
            .....|:...|                   .::||:|::||||.|:|:|.:|  .:.|...:.||
Mouse   474 ICPTDGTQTMDGFCSRSQHSSSTSHWRQEVVDVKTMMNTWTLQKGFPLITIT--VSGRNVHMKQE 536

  Fly   514 RYLLNTDVSRAHKGCWWVPLSYTNQEEKDFNNTAPKEWMECTETGESVP----KTIHD---LPGP 571
            .|:..::........|.|||::                  .|...:||.    ||..|   ||..
Mouse   537 HYMKGSERFPETGYLWHVPLTF------------------ITSKSDSVQRFLLKTKTDVLILPEA 583

  Fly   572 DQWVIFNNQLSAPYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIAL 636
            .||:.||..::..|.|:|....|..| ..|..|.:.:|...:||.||::........:...|.||
Mouse   584 VQWIKFNVGMNGYYIVHYADDGWASL-SGLLKEAHTTISSNDRASLINNAFQLVSIEKLSIEKAL 647

  Fly   637 QVISYLERERELLPWKSAFDNLQFVSGILRQTPNFRF------------FKNFTRRLITPIYEHL 689
            .:..||:.|.|::|...|.:.|         .|.::.            ||:|..:|:..:.:
Mouse   648 DLTLYLKNETEIMPIFQALNEL---------IPMYKLMEKRDMIEVETQFKDFLLKLLKDLID-- 701

  Fly   690 NGINDTVASEEQQDKTILKAIVADWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVV 754
               ..|...|....:.:|::.:...||......||.:|..::|.|:| :|.:  ..:|:.:...|
Mouse   702 ---KQTWTDEGSVSERMLRSQLLLLACVRNYQPCVQRAERYFREWKS-SNGN--MSIPIDVTLAV 760

  Fly   755 YCTAIKHGCDEDWDFLWTRYQKANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDST 819
            :....::  .|.||||:::||.:..:|||..|..||..|::...||..|:::|.| ..|:.|:..
Mouse   761 FAVGAQN--TEGWDFLYSKYQSSLSSTEKSQIEFSLCTSKDPEKLQWLLDQSFKG-EIIKTQEFP 822

  Fly   820 SVFQAIADSEVGFLLAKKYLMDNVDSISKFYHPQSESMSELLPPLSEQIFTQRDYDEFMNFMASS 884
            .:...|..:.||:.||.|:|.:|.:.:.:.:...|.|::.::...::|..|:...:|...|.:|.
Mouse   823 HILTLIGRNPVGYPLAWKFLRENWNKLVQKFELGSSSIAHMVMGTTDQFSTRARLEEVKGFFSSL 887

  Fly   885 KD---QLKDIEQTISQSLETMLINVQWKERNYERFTRAISK 922
            |:   ||:.::|||    ||:..|::|.::|:::....:.|
Mouse   888 KENGSQLRCVQQTI----ETIEENIRWMDKNFDKIRLWLQK 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	184/477 (39%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	87/342 (25%)
Erap1	NP_109636.1	M1_APN-Q_like	50..515	CDD:341064	184/478 (38%)
		Substrate binding. /evidence=ECO:0000250	306..310		3/3 (100%)
		ERAP1_C	586..905	CDD:403137	88/343 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	120	1.000	Domainoid score	I5730
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.920