DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and Erap1

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_006231762.1	Gene:	Erap1 / 80897	RGDID:	708542	Length:	954	Species:	Rattus norvegicus

Alignment Length:	985	Identity:	317/985 - (32%)
Similarity:	493/985 - (50%)	Gaps:	137/985 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AALGLSFAGEGSTYDHFRLPTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVLQNTHNITLHS 73
            |:.|.||     .:::.|||..:.|..||:.|...|..   ..|.|..:::|.|.|.|..|.:||
  Rat    30 ASNGASF-----LWNNMRLPEYITPIHYDLMIHANLST---LTFWGKTEVEITVSQPTSTIIMHS 86

  Fly    74 KDLTIDDTEITLSQIGGEETTENCITSTAVNPTHDFYILNTCKELLAGQFYELSLPFSAKLQDQL 138
            ..|.|  ::.||.: |.||..............|:...|.|.:.||||..|.:.:.::|.|.:..
  Rat    87 HQLQI--SKATLRR-GAEEMLPEEPLKLMEYSAHEQVALLTAQPLLAGSVYTVIITYAANLSENF 148

  Fly   139 AGYYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPV-- 201
            .|:|:|:| .|...|.|.::.|||||.|||:||||||||..||||:|.:....::..:||||:
  Rat   149 HGFYKSTY-RTQEGERRILAATQFEPTAARMAFPCFDEPALKASFSIKIKRDPRHLAISNMPLVK 212

  Fly   202 NETRPHESIPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAIDQCDYAAE 266
            :.|.....|.|:    |:.::.|||||||:.::||........:|.....:|.|:.|:|.|||.:
  Rat   213 SVTVAEGLIEDH----FDITVKMSTYLVAFIISDFKSVSKMTKSGVKVSVYAVPDKINQADYALD 273

  Fly   267 LGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETAN 331
            ....:|::||:.|.|.:||||.|..|:|||.:||||||||.|:.||.|||..|.||..:|.....
  Rat   274 AAVTLLEFYEDYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLYDKEKSSASSKLGITM 338

  Fly   332 IVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQL---------ESMS-- 385
            .|:||||||||||||||:||.|||||||||.::..:.|...||:.:.:|:         |.:|
  Rat   339 TVSHELAHQWFGNLVTMEWWNDLWLNEGFAKFMEFVSVTVTHPELKVMQILTANHQNEPEDLSGR 403

  Fly   386 ---------------NLLTIFRKDSLESSHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFL 435
                           |.:.:   |:|.||||:|.|:|..:||.|.|||:||:||:.::.|:..:|
  Rat   404 AMERTEEEYFFGKCFNAMEV---DALNSSHPVSTPVENPAQIREMFDEVSYEKGACILNMLRDYL 465

  Fly   436 GEEAFRTGLKSYLEKYTYKNAEQDNLWESLTQAAHKTGSLPKD-------------------YNI 481
            ..:.|:.|:..||:||:|||.:.::||.|:.......|:...|                   .:|
  Rat   466 SADTFKRGIVQYLQKYSYKNTKNEDLWNSMMHICPTDGTQTMDGFCSRNQHSSSTSHWRQEVIDI 530

  Fly   482 KTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNTDVSRAHKGCWWVPLSYTNQEEKDFNNT 546
            |::|::||||.|:|:|.:|  ...|...|.||.|:..::........|.|||::
  Rat   531 KSMMNTWTLQKGFPLITIT--VRGRNVHLKQEHYMKGSECFPETGSLWHVPLTF----------- 582

  Fly   547 APKEWMECTETGESVP----KTIHD---LPGPDQWVIFNNQLSAPYKVNYDAQNWKLLIETLNSE 604
                   .|...:||.    ||..|   ||...:|:.||..::..|.|:|....|..| ..|..|
  Rat   583 -------ITSKSDSVQRFLLKTKTDVIILPEAVEWIKFNVGMNGYYIVHYGDDGWASL-NGLLKE 639

  Fly   605 DYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLERERELLPWKSAFDNLQFVSGILRQTP 669
            .:.:|...:||.||::.......|:...|.||.:|.||:.|.|::|         ...|:....|
  Rat   640 AHTTISSNDRASLINNAFQLVSIGKLSIEKALDLILYLKNETEIMP---------IFQGLNELIP 695

  Fly   670 NFRF------------FKNFTRRLITPIYEHLNGIN-DTVASEEQQDKTILKAIVADWACSFEVS 721
            .::.            ||:|..||:..:      || .|...|....:.:|::.:...||.....
  Rat   696 MYKLMEKRDMVEVETQFKDFLLRLLKDL------INKQTWTDEGSVSERMLRSQLLLLACVHRYQ 754

  Fly   722 DCVTQALSFYRSWR-SEANPDEVNPVPLGIRGVVYCTAIKHGCDEDWDFLWTRYQKANVATEKQI 785
            .||.:|..::|.|: |..|..    :|:.:...|:....::  .|.||||:::||.:..:|||..
  Rat   755 LCVQRAERYFREWKASNGNMS----LPIDVTLAVFAVGAQN--TEGWDFLYSKYQSSLSSTEKSQ 813

  Fly   786 ILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIADSEVGFLLAKKYLMDNVDSISKFY 850
            |..||..||:...||..|:::|.| ..|:.|:...:...|..:.||:.||.|:|.:|.:.|.:.:
  Rat   814 IEFSLCISQDPEKLQWLLDQSFKG-EIIKTQEFPHILTLIGRNPVGYPLAWKFLKENWNKIVQKF 877

  Fly   851 HPQSESMSELLPPLSEQIFTQRDYDEFMNFMASSK---DQLKDIEQTISQSLETMLINVQWKERN 912
            ...|.|::.::...:.|..|:...:|...|.:|.|   .||:.::|||    ||:..|::|.::|
  Rat   878 ELGSSSIAHMVMGTTNQFSTRARLEEVKGFFSSLKKNGSQLRCVQQTI----ETIEENIRWMDKN 938

  Fly   913 YERFTRAISK 922
            :::....:.|
  Rat   939 FDKIRLWLQK 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	187/501 (37%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	93/344 (27%)
Erap1	XP_006231762.1	Peptidase_M1	42..454	CDD:279741	169/425 (40%)
		M1_APN_2	50..544	CDD:189008	191/507 (38%)
		ERAP1_C	611..927	CDD:288671	91/342 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	119	1.000	Domainoid score	I5647
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.920