DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and npepps

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001072690.1	Gene:	npepps / 780147	XenbaseID:	XB-GENE-1008338	Length:	875	Species:	Xenopus tropicalis

Alignment Length:	921	Identity:	291/921 - (31%)
Similarity:	442/921 - (47%)	Gaps:	102/921 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RLPTALRPQSYDVRILTQLENPD--DFHFNGTVKIQIEVLQNTHNITLHSKDLTIDDTEITLSQI 88
            ||||.:||.:|.:.:     .||  ||.|.|.::..:||...|:.|.::..|:.|    ||.|..
Frog     9 RLPTDVRPVNYGLCL-----KPDLIDFTFEGKLEATVEVQNATNQIVMNCADIDI----ITASYA 64

  Fly    89 --GGEETTENCITSTAVN-PTHDFYILNTCKELLAGQFYELSLPFSAKLQDQLAGYYRSSYVNTV 150
              |.||     |.:|..| ...|..:..:....|......|.:.|..:|.|::.|:|||.|. |.
Frog    65 PEGDEE-----IHATGFNYQNEDEKVTLSFPSTLQKGAGMLKIDFVGELNDKMKGFYRSKYA-TA 123

  Fly   151 ANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNETRPHESIPDYVW 215
            ..|.|:.:|||||...||.||||:|||..||:|.:.|...|....||||.:.:.:|:....:.|.
Frog   124 TGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDVILIVPKDRVALSNMNLIDRKPYPDDENLVE 188

  Fly   216 TSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAIDQCDYAAELGPKVLKYYEELFG 280
            ..|..:..|||||||:.:.::....:...:|.|.|.:......:|..:|.|:..|.|.:|::.|.
Frog   189 VKFARTPIMSTYLVAFVVGEYDFVETRSSDGVLVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFN 253

  Fly   281 IKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANIVAHELAHQWFGNL 345
            :.:||||:|.||:.||:|||||||||||:.|:.||..|:.|...::|..|.:|.|||||||||||
Frog   254 VPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGNL 318

  Fly   346 VTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLLTIFRKDSLESSHPISRPIEMTS 410
            |||:|||.||||||||:::..|||:...|::........::.......|:||:||||...:...|
Frog   319 VTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALENSHPIEVSVGHPS 383

  Fly   411 QISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQDNLWESLTQAAHKTGSL 475
            ::.|.||.|||.||:|||||:|.::|:|.||.|:..||.|:..|||..::|||||.||:.|.
Frog   384 EVDEIFDAISYSKGASVIRMLHDYIGDEDFRKGMNQYLTKFQEKNAATEDLWESLEQASGKP--- 445

  Fly   476 PKDYNIKTIMDSWTLQTGYPVINVTRDY--TSRTAKLSQERYLL----NTDVSRAHKGCWWVPLS 534
                 |..:|::||.|.|:|:|.|..:.  .|...||||:::..    |:|.|..    |.||:|
Frog   446 -----IAAVMNTWTKQMGFPLICVESEQKEDSVVLKLSQKKFCASGAPNSDDSYQ----WMVPIS 501

  Fly   535 YTNQEEKDFNNTAPKEWMECTETGESVPKTIHDLP---------GPDQWVIFNNQLSAPYKVNYD 590
            ....|                ....:..|.:.|.|         .|.|||..|......|:..|.
Frog   502 ICTSE----------------SPASATVKILMDKPEMTVVLEGVKPHQWVKLNPGTVGFYRTQYS 550

  Fly   591 AQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLERERELLPWKSAF 655
            ....:.|:..:..   .|:..|:|..|.:|:...|..|..:....|:|:.....|.....|....
Frog   551 TTMLESLLPGIRD---LSLQPVDRLGLQNDLFSLARAGMINTAEVLKVMEAFVNEPNYTVWSDLS 612

  Fly   656 DNLQFVSGILRQTPNFRFFKNFTRRLITPIYEHLNGINDTVASEEQQDKTILKAIVADWACSFEV 720
            .||..:|.:|..|......:.|.|.:.:||.:.|..  |....|...| .:|:.:|..     ::
Frog   613 CNLGILSTLLSHTDFHEEIQCFVRDVFSPIGQRLGW--DPKPGEGHLD-ALLRGLVLG-----KL 669

  Fly   721 SDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGCDEDWDFLWTRYQKANVATEKQI 785
            .....|........|.:.:.|..|.:...:|..||.|.:|||.:...:.:...:::|::..||..
Frog   670 GKAGHQPTLEEARRRFKEHVDGRNVLSADLRSPVYVTVLKHGDNSTLETMMKLHKQADMQEEKNR 734

  Fly   786 ILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIA-DSEVGFLLAKKYLMDNVDSISKF 849
            |...||...|..::::.|  :|....|:|.||:..|...:| .|::|...|..::.||.:.:...
Frog   735 IERVLGAIAEQDLIKKVL--SFSLSEDVRPQDTVCVIGGVAGGSKLGRKCAWNFVKDNWEELYNR 797

  Fly   850 YHPQSESMSELLPPLSEQIFTQRDYDEFMNFMASSK--DQLK---------DIEQTISQSLETML 903
            |  |...:...|..||            ::..||.|  .::|         ..|:|:.|..|.:|
Frog   798 Y--QGGFLISRLIKLS------------LDGFASDKMAAEIKAFFDAHPAPSAERTVQQCCENIL 848

  Fly   904 INVQWKERNYE 914
            :|..|.:|:.|
Frog   849 LNAGWLKRDAE 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	180/459 (39%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	76/339 (22%)
npepps	NP_001072690.1	Peptidase_M1	9..397	CDD:279741	156/402 (39%)
		M1_APN_2	17..460	CDD:189008	183/465 (39%)
		ERAP1_C	535..846	CDD:288671	74/337 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010