DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and Lvrn

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_083284.1	Gene:	Lvrn / 74574	MGIID:	1921824	Length:	991	Species:	Mus musculus

Alignment Length:	947	Identity:	296/947 - (31%)
Similarity:	452/947 - (47%)	Gaps:	114/947 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 YDHFRLPTALRPQSYDVRILTQLE----NPDDFHFNGTVKIQIEVLQNTHNITLHSKDLTIDDTE 82
            :||.|||..|.|..||:.:...|:    :|.:..|.|.|.|.:.....:..:.|||..|.....|
Mouse    90 WDHLRLPPWLVPLHYDLELWPWLQPDKLSPPNLTFTGRVNITVRCTVASSRLLLHSFLLNYKQVE 154

  Fly    83 I--TLSQIGGEETTENCITSTAVN-----PTHDFYILNTCKELLAGQFYELSLPFSAK-LQDQLA 139
            :  .|:|    :|....:....|.     |...|.:|:..:.|..|..||||..||.: ||..|.
Mouse   155 VWGPLAQ----DTRNATVGRVQVEKVWFAPDMQFVVLDLGQSLEPGSRYELSFHFSGQVLQVGLE 215

  Fly   140 GYYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMP---- 200
            |.:.:.|.:  .:|.|.:..||.||..||..|||||||..||:|.||:.:|..|..|||||
Mouse   216 GLFLNLYHD--EDELRALVATQMEPTFARHVFPCFDEPALKATFNITVIHHPGYAALSNMPQLGQ 278

  Fly   201 -----VNETRPHESIPDYVW--TSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPN-- 256
                 ||.:|         |  |:|..:..|.|||||..:.|..|...| ..|...|.|||.:
Mouse   279 SERIDVNGSR---------WTVTTFHTTPRMPTYLVALVVCDLDHISRT-ERGKEIRVWARKDDI 333

  Fly   257 AIDQCDYAAELGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYS 321
            |....|:||.:...:..:.|:||.|.:.|||.|.:|:|.|::||||||||:.|.||:||..||..
Mouse   334 ASGYLDFAANITGPIFSFLEDLFNISYRLPKTDIVALPIFASGAMENWGLLIFDESSLLLEPEDE 398

  Fly   322 SQEAKQETANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSN 386
            ..|.:....:|:|||:.||||||||||.||.::|||||||:|.........:|:.....:...:.
Mouse   399 LTEKRAMILSIIAHEVGHQWFGNLVTMSWWNNIWLNEGFASYFELELTNYFYPKVPMNMIFFFTV 463

  Fly   387 LLTIFRKDSLESSHPISRPIE---MTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYL 448
            |..|..:|....|..:|..:|   .||:|:..||..:|:||:.:..|:..||....|...|||||
Mouse   464 LHGILGEDHALESRAVSTAVENFTETSEINRLFDLYTYKKGACMAWMLASFLSPHLFINALKSYL 528

  Fly   449 EKYTYKNAEQDNLWESLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQE 513
            |.::|.|||||:||..:..|..:.........:|.||||||.:.|:|:|.|    ...|..:.||
Mouse   529 ETFSYSNAEQDDLWRHIQMAIGEQNVTHLPATVKGIMDSWTHRGGFPIITV----NVSTGVVKQE 589

  Fly   514 RYLLN---TDVSRAHKGCWWVPLSYTNQEEKDFNNTAPKE--WMECTETGESVPKTIHDLPG--- 570
            .:.|:   .....:|...|.||:.:       ..|..|:.  |::         |:....||
Mouse   590 PFYLDKVENQTLLSHNSTWIVPIFW-------MKNGIPQPLVWLD---------KSNMMFPGMKL 638

  Fly   571 ---PDQWVIFNNQLSAPYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDY 632
               ...|||.|..::..|:||||...||.|.|.| .:|..:|.|:||.||:.|..........:.
Mouse   639 SDSDSDWVILNFNVTGYYRVNYDELGWKKLSEQL-EKDPKAIPVINRLQLVSDAFALTKNNYIEI 702

  Fly   633 EIALQVISYLERERELLPWKSAFDNLQFVSGILRQTPNFRFF---KNFTRRLITPIYEHLNG-IN 693
            |.||.:..|:..|.|:|.|.....|| ....::....|:..:   |.:..:....|:...:. |.
Mouse   703 ETALDLTKYIAEEDEILVWFEVLLNL-INREVIYDVNNYALYPLLKKYLLKRFNSIWNTYSAIIR 766

  Fly   694 DTVASEEQQDKTILK-AIVADWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCT 757
            :.|||.:....::.. ..:.:.||...:.||:..:...::.|  .|:|:  ..:|..|...|.|:
Mouse   767 ENVASLQDNYLSLFSLERIFETACWLGLEDCLQLSRELFKKW--TAHPE--TAIPPQIENAVLCS 827

  Fly   758 AIKHGCDEDWDFLWTRYQKANVATE-----KQIILDSLGCSQEVWVLQRYLE-------RNFDGM 810
            |:..|.|:|||||:..|  .|...|     ::.::.::.||::.|:|.|::|       .||
Mouse   828 AVALGSDKDWDFLFNLY--INTTEEEDESRRRRLVHAMSCSKDPWILNRFMEYAITAVSSNF--- 887

  Fly   811 GDIRKQDSTSVFQAIADSEVGFLLAKKYLMDNVDSISKFYHPQSESMSELLPPLSEQIFTQRDYD 875
                  ..|::...:|.||||..:||.:||||..::::.|  ..:.:..|:|.|...:.|.:...
Mouse   888 ------SETNIIVVVATSEVGRYIAKDFLMDNWVAVTERY--GMDWLDALVPVLGRTVSTDQQVT 944

  Fly   876 EFMNFMAS-SKDQLKDIEQTISQSLETMLINVQWKER 911
            |..:|.:: .::..:.:.|...|:::|.  |:|.|:|
Mouse   945 ELQHFFSTVLEEHQRVVVQAKLQAMKTK--NLQNKKR 979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	175/482 (36%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	90/345 (26%)
Lvrn	NP_083284.1	Peptidase_M1	94..504	CDD:279741	153/425 (36%)
		M1_APN_2	102..575	CDD:189008	177/488 (36%)
		Substrate binding. /evidence=ECO:0000250	376..380		3/3 (100%)
		ERAP1_C	646..964	CDD:288671	87/336 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2868
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.770