DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11951 and ERAP2

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001123612.1	Gene:	ERAP2 / 64167	HGNCID:	29499	Length:	960	Species:	Homo sapiens

Alignment Length:	941	Identity:	300/941 - (31%)
Similarity:	471/941 - (50%)	Gaps:	96/941 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GEGSTYDHFRLPTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVLQNTHNITLHSKDLTIDDT 81
            ||...:...|||:.:.|..||:.:...|.:.|   |..:.||::.|...|..|.||||||
Human    59 GERFPWQELRLPSVVIPLHYDLFVHPNLTSLD---FVASEKIEVLVSNATQFIILHSKDL----- 115

  Fly    82 EITLSQIGGEETTENCITSTAVN----PTHDFYILNTCKELLAGQFYELSLPFSAKLQDQLAGYY 142
            |||.:.:..||.:........:.    |.|:...|...::|.....|.:::.|.|||.|...|:|
Human   116 EITNATLQSEEDSRYMKPGKELKVLSYPAHEQIALLVPEKLTPHLKYYVAMDFQAKLGDGFEGFY 180

  Fly   143 RSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNETRPH 207
            :|:| .|:..|||.::||.|||..||:||||||||.:||:|:|.:....::..|||||..:|...
Human   181 KSTY-RTLGGETRILAVTDFEPTQARMAFPCFDEPLFKANFSIKIRRESRHIALSNMPKVKTIEL 244

  Fly   208 ES--IPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAIDQCDYAAELGPK 270
            |.  :.|:    ||.::.||||||||.:.||........:|.....:|.|:..:|..||.:...|
Human   245 EGGLLEDH----FETTVKMSTYLVAYIVCDFHSLSGFTSSGVKVSIYASPDKRNQTHYALQASLK 305

  Fly   271 VLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANIVAH 335
            :|.:||:.|.|.:||.|:|.||:|||:.||||||||:|:.|::||:.|:.||...|.....::||
Human   306 LLDFYEKYFDIYYPLSKLDLIAIPDFAPGAMENWGLITYRETSLLFDPKTSSASDKLWVTRVIAH 370

  Fly   336 ELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLES--MSNLLTIFRKDSLES 398
            |||||||||||||:||.|:||.||||.|:..:.|...:|:   ||.:.  ::....:..||||.|
Human   371 ELAHQWFGNLVTMEWWNDIWLKEGFAKYMELIAVNATYPE---LQFDDYFLNVCFEVITKDSLNS 432

  Fly   399 SHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQDNLWE 463
            |.|||:|.|..:||.|.|||:||.||:.::.|:..|||||.|:.|:..||:|::|:||:.|:||.
Human   433 SRPISKPAETPTQIQEMFDEVSYNKGACILNMLKDFLGEEKFQKGIIQYLKKFSYRNAKNDDLWS 497

  Fly   464 SLTQA-------------------AHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAK 509
            ||:.:                   ::....|.::..:|.:|.:||||.|.|::.|.:|..|  .:
Human   498 SLSNSCLESDFTSGGVCHSDPKMTSNMLAFLGENAEVKEMMTTWTLQKGIPLLVVKQDGCS--LR 560

  Fly   510 LSQERYL---LNTDVS-RA--HKGCWWVPLSYTNQEEKDFNNTAPKEWMECTETGESVPKTIHDL 568
            |.|||:|   ...|.. ||  .:..|.:||:|:.......:....|          |...|: ||
Human   561 LQQERFLQGVFQEDPEWRALQERYLWHIPLTYSTSSSNVIHRHILK----------SKTDTL-DL 614

  Fly   569 PGPDQWVIFNNQLSAPYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYE 633
            |....||.||...:..|.|:|:...|..||..|| :::..:...:|..||.||......|....:
Human   615 PEKTSWVKFNVDSNGYYIVHYEGHGWDQLITQLN-QNHTLLRPKDRVGLIHDVFQLVGAGRLTLD 678

  Fly   634 IALQVISYLERERELLPWKSAFDNLQFVSGILRQTPNFRFFKNFTRRLITPIYEHLNG-----IN 693
            .||.:..||:.|...   .:..:.|.::..         |:....||.|:.|.|:|..     ..
Human   679 KALDMTYYLQHETSS---PALLEGLSYLES---------FYHMMDRRNISDISENLKRYLLQYFK 731

  Fly   694 DTVASEEQQDK-----TILKAIVADWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGV 753
            ..:..:...||     .:|::.:...||....:.|:.:|...:..|...:.  ::| :|..:..:
Human   732 PVIDRQSWSDKGSVWDRMLRSALLKLACDLNHAPCIQKAAELFSQWMESSG--KLN-IPTDVLKI 793

  Fly   754 VYCTAIKHGCDEDWDFLWTRYQKANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDS 818
            ||....:  ....|::|..:|:.:..:.|:..||.:|..|:....|.:.:|...:|. .|:.|:.
Human   794 VYSVGAQ--TTAGWNYLLEQYELSMSSAEQNKILYALSTSKHQEKLLKLIELGMEGK-VIKTQNL 855

  Fly   819 TSVFQAIADSEVGFLLAKKYLMDNVDSISKFYHPQSESMSELLPPLSEQIFTQRDYDEFMNFMAS 883
            .::..|||....|..||..::.:|...:.|.:...|..:..::...:....::....|...|..|
Human   856 AALLHAIARRPKGQQLAWDFVRENWTHLLKKFDLGSYDIRMIISGTTAHFSSKDKLQEVKLFFES 920

  Fly   884 SKDQLK--DIEQTISQSLETMLINVQWKERN 912
            .:.|..  ||.||:   |||:..|::|.|:|
Human   921 LEAQGSHLDIFQTV---LETITKNIKWLEKN 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	188/481 (39%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	75/339 (22%)
ERAP2	NP_001123612.1	Peptidase_M1	68..458	CDD:279741	167/405 (41%)
		M1_APN_2	76..548	CDD:189008	192/487 (39%)
		Substrate binding	334..338		3/3 (100%)
		ERAP1_C	621..938	CDD:288671	74/338 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920