Protein Alignment CG11951 and RNPEPL1

DIOPT Version :10

• Sequence 1: NP_001350853.2
• Gene: CG11951 / 43463
• FlyBaseID: FBgn0039656
• Length: 842
• Species: Drosophila melanogaster
• Sequence 2: NP_060696.4
• Gene: RNPEPL1 / 57140
• HGNCID: 10079
• Length: 725
• Species: Homo sapiens
• Alignment Length: 567
• Identity: 135/567 - (23%)
• Similarity: 216/567 - (38%)
• Gaps: 125/567 - (22%)

  Fly    97 CITSTAVNPTHDF---YILNTCKELLAGQFYELSLPFSAKLQDQLAGYYRSSYVNTVANETRWIS 158
            |..:..|:|..|:   ..:....||.|.|      ||...|:          |.:|.|....|:.
Human   133 CPLAFRVDPFTDYGSSLTVTLPPELQAHQ------PFQVILR----------YTSTDAPAIWWLD 181

  Fly   159 ------------VTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNETRPHESIP 211
                        .||......|..|||||.|..|.:::..:   |..:|:..: ::.||......
Human   182 PELTYGCAKPFVFTQGHSVCNRSFFPCFDTPAVKCTYSAVV---KAPSGVQVL-MSATRSAYMEE 242

  Fly   212 DYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARP-----------NAIDQCDYAA 265
            :.|: .|....|:..||||....|.  ||:.:  |...|.||.|           .|::|...||
Human   243 EGVF-HFHMEHPVPAYLVALVAGDL--KPADI--GPRSRVWAEPCLLPTATSKLSGAVEQWLSAA 302

  Fly   266 E--LGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQE 328
            |  .||.:...|:.:|     ||       |.|...|||| ..:||..|::|.|.|:...:
Human   303 ERLYGPYMWGRYDIVF-----LP-------PSFPIVAMEN-PCLTFIISSILESDEFLVID---- 350

  Fly   329 TANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATY-----------VASLCVEDIHPQWRTLQLE 382
                |.||:||.||||.||...|.::||:||.|||           .|..|:|      ...:|:
Human   351 ----VIHEVAHSWFGNAVTNATWEEMWLSEGLATYAQRRITTETYGAAFTCLE------TAFRLD 405

  Fly   383 SMSNLLTIFRKDSLESSHPISR---PIEMTSQISESFDEISYQKGSSVIRMMHLFLGE-EAFRTG 443
            ::...:.:..:||     |:|:   .:|.....|...:..:|:||...:..:....|: :.|...
Human   406 ALHRQMKLLGEDS-----PVSKLQVKLEPGVNPSHLMNLFTYEKGYCFVYYLSQLCGDPQRFDDF 465

  Fly   444 LKSYLEKYTYKNAEQDNLWESLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTA 508
            |::|:|||.:.:....:|.:|......:......|.......:.|...||.|:........|...
Human   466 LRAYVEKYKFTSVVAQDLLDSFLSFFPELKEQSVDCRAGLEFERWLNATGPPLAEPDLSQGSSLT 530

  Fly   509 KLSQERYLLNTDVSRAHKGCWWV--PLSYTNQEEKDFNNTAPKEWMECTETGESVPKTIHDLPGP 571
            :..:..:.|            |.  ||   :|.....:.....:| ...:|...:.:.:...|.|
Human   531 RPVEALFQL------------WTAEPL---DQAAASASAIDISKW-RTFQTALFLDRLLDGSPLP 579

  Fly   572 DQWVIFNNQLSAPYKVNYDAQNWKLLIETL----NSEDYHSIHVVNR 614
            .:.|:   .||..|....|:.|.::.|..|    .::.|..:|.|.|
Human   580 QEVVM---SLSKCYSSLLDSMNAEIRIRWLQIVVRNDYYPDLHRVRR 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	110/435 (25%)
		ERAP1_C	574..902	CDD:463368	12/45 (27%)
RNPEPL1	NP_060696.4	M1_LTA4H	29..512	CDD:341062	110/435 (25%)
		Leuk-A4-hydro_C	560..673	CDD:462686	16/68 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	676..699