DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and si:ch211-276a23.5

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_001922987.2	Gene:	si:ch211-276a23.5 / 555317	ZFINID:	ZDB-GENE-141215-4	Length:	956	Species:	Danio rerio

Alignment Length:	942	Identity:	323/942 - (34%)
Similarity:	473/942 - (50%)	Gaps:	114/942 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 YDHFRLPTALRPQSYDVRILTQLENPD--DFHFNGTVKIQIEVLQNTHNITLHSKD----LTIDD 80
            :|.:|||..|.|:.|::.:..:|...|  .:.|.|...:....::.|..|.:||.:    ||.:.
Zfish    65 WDKYRLPDTLLPEYYNITLWPRLTKDDLGMYIFTGKSGVAFLCVKETDLILIHSSNLNYSLTAEK 129

  Fly    81 TEITLSQIGGEETTENCITSTAVNPTHDFYILNTCKELLAGQFYELSLPFSAKLQDQLAGYYRSS 145
            ....|..:||  |....|..|......:|.::...:.|..|:.|.|...|..:|.|.|.|:|||.
Zfish   130 HHAELMGLGG--TRAPVILKTWFQDQTEFMVIQLRENLQVGKSYWLYTEFQGELADDLGGFYRSE 192

  Fly   146 YVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYT-----GLSNMPVNETR 205
            ||.....:.  ::.||.:|.|||.||||||||..||.|.:|| .|...|     |:.....|.|.
Zfish   193 YVENGVEKV--VATTQMQPTAARTAFPCFDEPSMKAVFHLTL-IHPPGTVALANGMETGTENITI 254

  Fly   206 PHESIPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTL-PNGTLFRTWARPNAID--QCDYAAEL 267
            .::.:   :.|.||.:..|||||:|:.:::|....|.| .|..|.|.|.|..||:  :.|||..:
Zfish   255 ENQQV---LQTRFEPTEKMSTYLLAFVISEFPSIQSPLGANKILVRIWGRREAIENGEGDYALNV 316

  Fly   268 GPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANI 332
            ...||||.|..:...:||.|.||||:|||||||||||||||:.|:.|.|.|:.||.|.|:....:
Zfish   317 TFPVLKYLESYYNTTYPLSKSDQIALPDFSAGAMENWGLVTYRETFLFYEPKVSSHEDKEGVITV 381

  Fly   333 VAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLLTIFRKDSLE 397
            ::|||||.||||||||:||.|||||||||:||:.|..:...|.|...:|..:..:...|..|:|.
Zfish   382 ISHELAHMWFGNLVTMRWWNDLWLNEGFASYVSYLAADYAEPTWNIKELMVLQQVYRAFTVDALV 446

  Fly   398 SSHPISR---PIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQD 459
            ||||:|.   .:....||.|.||.::|.||::|:||:..||.|..|..||.:||:::.|.|....
Zfish   447 SSHPLSSREDAVNTPQQIEELFDAVTYSKGAAVLRMLSEFLSESVFAKGLHNYLQEHAYSNTVYT 511

  Fly   460 NLWESLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNTD--VS 522
            :||:.|.:.|...|::....:|:.||:.|.||.|:||:.:    .:.|..:||:.:|::.:  |:
Zfish   512 DLWKKLQEVADSDGNVHLPASIEEIMNRWILQAGFPVVTI----DTHTGSISQQHFLIDPEAVVN 572

  Fly   523 RA--HKGCWWVPLSYTNQEEKDFNNTAPKEWMECTETGESVPKTIHDLPGPDQWVIFNNQLSAPY 585
            :.  :...|:||:::.    |:..|.. :.|:....|...:.||      ...|::.|..::..|
Zfish   573 KPSDYNYEWFVPITWM----KNGRNMG-QHWLLNKSTSYELMKT------ETNWILANLNVTGYY 626

  Fly   586 KVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLERERELLP 650
            :||||:|||:.||:.|.| |:.:|.|:||.|:|||....|.....:..:||:...||..|:|.:|
Zfish   627 RVNYDSQNWERLIKQLTS-DHQAIPVLNRGQIIDDAFTLARAKILNITMALRTTQYLSNEKEYIP 690

  Fly   651 WKSAFDNLQF---------VSGIL------RQTPNFRFFK----NFTRRLITPIYEHLNGINDTV 696
            |:||..||::         |.|.|      :..|.|.:||    |:||:   |. .|::..|.
Zfish   691 WESAIRNLEYFFLMFDRTEVRGPLEAYLRRKVEPLFHYFKVITSNWTRK---PT-RHMDQYNQ-- 749

  Fly   697 ASEEQQDKTILKAIVADWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKH 761
                      |.||.  .||...|..|......:||.|..:.|   |||||..::.||||.||..
Zfish   750 ----------LNAIT--MACKTRVKACSELTSMWYRQWMKDPN---VNPVPSDLKTVVYCNAIAA 799

  Fly   762 GCDEDWDFLWTRYQKANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIA 826
            |..|:|||.|..::.:.||.|.:.::..|.|::|.|:|.|||....| ...|||||.|.....||
Zfish   800 GGVEEWDFGWAMFKNSTVAAEAEKLMYGLSCTKEPWLLNRYLHYAID-PNLIRKQDVTYPIVYIA 863

  Fly   827 DSEVG------FLLAKKYLMDN-----VDSISKFYHPQSESMSELLPPLSEQIFTQRDYDEFMNF 880
            .:.:|      |..||..||..     :..|.|.:..:               |..:....|...
Zfish   864 SNVIGQPLAWDFFRAKWQLMTTEFRVLILGIVKTFSTE---------------FQLQQLQRFQEE 913

  Fly   881 MASSKDQLKDIEQTISQSLETMLINVQWKERN 912
            :|.|...|.  ...|.|::|....||:|...|
Zfish   914 VAESGVSLG--THAIEQAIEQTKANVKWVSEN 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	181/471 (38%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	113/357 (32%)
si:ch211-276a23.5	XP_001922987.2	M1_APN_2	79..547	CDD:189008	184/475 (39%)
si:ch211-276a23.5	XP_001922987.2	ERAP1_C	615..935	CDD:314669	113/359 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		mtm6446
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.920