DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and ERAP1

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_005272072.1	Gene:	ERAP1 / 51752	HGNCID:	18173	Length:	951	Species:	Homo sapiens

Alignment Length:	933	Identity:	298/933 - (31%)
Similarity:	481/933 - (51%)	Gaps:	92/933 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 YDHFRLPTALRPQSYDVRI---LTQLENPDDFHFNGTVKIQIEVLQNTHNITLHSKDLTIDDTEI 83
            ::..|||..:.|..||:.|   ||.|.      |.||.|::|...|.|..|.|||..|.|  :..
Human    49 WNKIRLPEYVIPVHYDLLIHANLTTLT------FWGTTKVEITASQPTSTIILHSHHLQI--SRA 105

  Fly    84 TLSQIGGEETTENCITSTAVNPTHDFYILNTCKELLAGQFYELSLPFSAKLQDQLAGYYRSSYVN 148
            ||.:..||..:|..: ....:|..:...|...:.||.|..|.:.:.::..|.:...|:|:|:| .
Human   106 TLRKGAGERLSEEPL-QVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTY-R 168

  Fly   149 TVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPV--NETRPHESIP 211
            |...|.|.::.|||||.|||:||||||||.:||||:|.:....::..:||||:  :.|.....|.
Human   169 TKEGELRILASTQFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAISNMPLVKSVTVAEGLIE 233

  Fly   212 DYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAIDQCDYAAELGPKVLKYYE 276
            |:    |:.::.|||||||:.::||........:|.....:|.|:.|:|.|||.:....:|::||
Human   234 DH----FDVTVKMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYE 294

  Fly   277 ELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANIVAHELAHQW 341
            :.|.|.:||||.|..|:|||.:||||||||.|:.||.||:..|.||..:|......|||||||||
Human   295 DYFSIPYPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLGITMTVAHELAHQW 359

  Fly   342 FGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLLTIFRKDSLESSHPISRPI 406
            |||||||:||.|||||||||.::..:.|...||:.:.... ...........|:|.||||:|.|:
Human   360 FGNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDY-FFGKCFDAMEVDALNSSHPVSTPV 423

  Fly   407 EMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQDNLWESL------ 465
            |..:||.|.||::||.||:.::.|:..:|..:||::|:..||:|::|||.:.::||:|:
Human   424 ENPAQIREMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWDSMASICPT 488

  Fly   466 ----------TQAAHKTGSL---PKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLL 517
                      :::.|.:.|.   .:..::||:|::||||.|:|:|.:|  ...|...:.||.|:.
Human   489 DGVKGMDGFCSRSQHSSSSSHWHQEGVDVKTMMNTWTLQKGFPLITIT--VRGRNVHMKQEHYMK 551

  Fly   518 NTDVSRAHKGCWWVPLSYTNQEEKDFNNTAPKEWMECTETGESVPKTIHDLPGPDQWVIFNNQLS 582
            .:|.:......|.|||::...:....:....|     |:|...:      ||...:|:.||..::
Human   552 GSDGAPDTGYLWHVPLTFITSKSDMVHRFLLK-----TKTDVLI------LPEEVEWIKFNVGMN 605

  Fly   583 APYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLERERE 647
            ..|.|:|:...|..|...|.. .:.::...:||.||::.......|:...|.||.:..||:.|.|
Human   606 GYYIVHYEDDGWDSLTGLLKG-THTAVSSNDRASLINNAFQLVSIGKLSIEKALDLSLYLKHETE 669

  Fly   648 LLPWKSAFDNLQFVSGILRQTPNFRF------------FKNFTRRLITPIYEHLNGINDTVASEE 700
            ::|         ...|:....|.::.            ||.|..||:..:.:     ..|...|.
Human   670 IMP---------VFQGLNELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLID-----KQTWTDEG 720

  Fly   701 QQDKTILKAIVADWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGCDE 765
            ...:.:|::.:...||......||.:|..::|.|: |:|.:...||.:.:  .|:  |:.....|
Human   721 SVSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWK-ESNGNLSLPVDVTL--AVF--AVGAQSTE 780

  Fly   766 DWDFLWTRYQKANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIADSEV 830
            .||||:::||.:..:|||..|..:|..:|....||..|:.:|.| ..|:.|:...:...|..:.|
Human   781 GWDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKG-DKIKTQEFPQILTLIGRNPV 844

  Fly   831 GFLLAKKYLMDNVDSISKFYHPQSESMSELLPPLSEQIFTQRDYDEFMNFMASSKD---QLKDIE 892
            |:.||.::|..|.:.:.:.:...|.|::.::...:.|..|:...:|...|.:|.|:   ||:.::
Human   845 GYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFFSSLKENGSQLRCVQ 909

  Fly   893 QTISQSLETMLINVQWKERNYER 915
            |||    ||:..|:.|.::|:::
Human   910 QTI----ETIEENIGWMDKNFDK 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	183/478 (38%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	86/342 (25%)
ERAP1	XP_005272072.1	M1_APN_2	61..531	CDD:189008	187/484 (39%)
ERAP1	XP_005272072.1	ERAP1_C	597..916	CDD:314669	87/343 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920