DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and Npepps

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_536320.1	Gene:	Npepps / 50558	RGDID:	619962	Length:	920	Species:	Rattus norvegicus

Alignment Length:	924	Identity:	298/924 - (32%)
Similarity:	454/924 - (49%)	Gaps:	78/924 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LAALGLSFAGEGSTYDHFRLPTALRPQSYDVRILTQLENPD--DFHFNGTVKIQIEVLQNTHNIT 70
            |.:|||:...|...::  ||||.:.|.:|.:.:     .||  ||.|.|.::...:|.|.|:.|.
  Rat    38 LHSLGLAAMPEKRPFE--RLPTEVSPINYSLCL-----KPDLLDFTFEGKLEAAAQVRQATNQIV 95

  Fly    71 LHSKDLTIDDTEITLSQI--GGEETTENCITSTAVN-PTHDFYILNTCKELLAGQFYELSLPFSA 132
            ::..|:.|    ||.|..  |.||     |.:|..| ...|..:..:....|......|.:.|..
  Rat    96 MNCADIDI----ITASYAPEGDEE-----IHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVG 151

  Fly   133 KLQDQLAGYYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLS 197
            :|.|::.|:|||.| .|.|.|.|:.:|||||...||.||||:|||..||:|.|:|...|....||
  Rat   152 ELNDKMKGFYRSRY-TTPAGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALS 215

  Fly   198 NMPVNETRPHESIPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAIDQCD 262
            ||.|.:.:|:....:.|...|..:..|||||||:.:.::....:...:|...|.:......:|..
  Rat   216 NMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGK 280

  Fly   263 YAAELGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQ 327
            :|.|:..|.|.:|::.|.:.:||||:|.||:.||:|||||||||||:.|:.||..|:.|...::|
  Rat   281 FALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQ 345

  Fly   328 ETANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLLTIFR 392
            ..|.:|.||||||||||||||:|||.||||||||:::..|||:...|::........::......
  Rat   346 WVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQE 410

  Fly   393 KDSLESSHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAE 457
            .|:|::||||...:...|::.|.||.|||.||:|||||:|.::|::.|:.|:..||.|:..|||.
  Rat   411 LDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAA 475

  Fly   458 QDNLWESLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYT--SRTAKLSQERYLLNTD 520
            .::|||||..|:.|.        |..:|::||.|.|:|:|.|..:..  .|..||||:::.
  Rat   476 TEDLWESLESASGKP--------IAAVMNTWTKQMGFPLIYVEAEQVEDDRVLKLSQKKFC---- 528

  Fly   521 VSRAHKG--C--WWVPLSYTNQEEKDFNNTAPKEWMECTETGESVPKTIHDLPGPDQWVIFNNQL 581
            .|..:.|  |  |.||::.:..|  |.|....|..|:..|. ..|.|.:.    |||||..|...
  Rat   529 ASGPYVGEDCPQWMVPITISTSE--DPNQAKLKILMDKPEM-SVVLKNVK----PDQWVKLNLGT 586

  Fly   582 SAPYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLERER 646
            ...|:..|.:...:.|:..:..   .|:..|:|..|.:|:...|..|.......|:|:.....|.
  Rat   587 VGFYRTQYSSAMLESLLPGIRD---LSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEP 648

  Fly   647 ELLPWKSAFDNLQFVSGILRQTPNFRFFKNFTRRLITPIYEHLNGINDTVASEEQQDKTILKAIV 711
            ....|.....||..:|.:|..|..:...:.|.:.:.:||.|.|..  |....|...| .:|:.:|
  Rat   649 NYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLGW--DPKPGEGHLD-ALLRGLV 710

  Fly   712 ------ADWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGCDEDWDFL 770
                  |....:.|.:         .|.::......::  :...:|..||.|.:|||.....|.:
  Rat   711 LGKLGKAGHKATLEEA---------RRRFKEHVEGKQI--LSADLRSPVYLTVLKHGDGTTLDIM 764

  Fly   771 WTRYQKANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIA-DSEVGFLL 834
            ...:::|::..||..|...||.:....::|:.|  .|....::|.||:.||...:| .|:.|...
  Rat   765 LKLHKQADMQEEKNRIERVLGATLSPELIQKVL--TFALSEEVRPQDTVSVIGGVAGGSKHGRKA 827

  Fly   835 AKKYLMDNVDSISKFYHPQSESMSELLPPLSEQIF-TQRDYDEFMNFMASSKDQLKDIEQTISQS 898
            |.|::.||.:.:...|  |...:...|..||.:.| ..:...|...|..|  ......|:||.|.
  Rat   828 AWKFIKDNWEELYNRY--QGGFLISRLIKLSVEGFAVDKMAGEVKAFFES--HPAPSAERTIQQC 888

  Fly   899 LETMLINVQWKERN 912
            .|.:|:|..|.:|:
  Rat   889 CENILLNAAWLKRD 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	178/459 (39%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	78/335 (23%)
Npepps	NP_536320.1	Peptidase_M1	54..442	CDD:279741	156/402 (39%)
		M1_APN_2	62..505	CDD:189008	181/465 (39%)
		ERAP1_C	580..891	CDD:288671	76/333 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920