DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11951 and enpep

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001186660.1	Gene:	enpep / 504088	ZFINID:	ZDB-GENE-050309-218	Length:	951	Species:	Danio rerio

Alignment Length:	916	Identity:	286/916 - (31%)
Similarity:	464/916 - (50%)	Gaps:	68/916 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 YDHFRLPTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVLQNTHNITLHSKDLTIDDTEITLS 86
            :.:||||..:.|..||:.:...| |.|  .:.|.|.:.:::.|.:.::.||     |.||.:|:.
Zfish    76 WSNFRLPDYILPFHYDLHMEPDL-NTD--IYTGDVSVHLKLTQPSQHLWLH-----IRDTFVTVM 132

  Fly    87 QIGGEETTENCITSTAVNPTHDF----YILNTCKELLA----GQFYELSLPFSAKLQDQLAGYYR 143
            . ..:.::.:.:||..:....::    |::....|.|:    .:.|.|:|.|...|...|.|:||
Zfish   133 P-SLQRSSPSGVTSVKLKQCFEYKPQEYVVVEAAEQLSVTGPDEHYVLTLHFQGWLNGSLVGFYR 196

  Fly   144 SSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNETRPHE 208
            ::|...  ..|:.|:.|..||..||.:|||||||..||::.|::.:...|..||||||.:|   |
Zfish   197 TTYQEN--GVTKKIAATDHEPTDARKSFPCFDEPNKKATYTISITHDSTYKALSNMPVEKT---E 256

  Fly   209 SIPDY-VWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAIDQCDYAAELGPKVL 272
            .:.:. ..|||.:|:.||||||.::::.|.....|...|...|.:|:|..|....|||::...:.
Zfish   257 KLSEQKTKTSFMKSVKMSTYLVCFAVHQFDFVERTSKRGIPLRIYAQPLQISTAAYAADVTQVIF 321

  Fly   273 KYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANIVAHEL 337
            .|:||.|.:::.:.|:|:||:|||..||||||||:|:.|:.||:..:.||...||..|:::||||
Zfish   322 DYFEEYFDMEYSIQKLDKIAIPDFGTGAMENWGLITYRETNLLFDEKESSSVNKQRVASVIAHEL 386

  Fly   338 AHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLLTIFRKDSLESSHPI 402
            .||||||:|||.||.|||||||||::...:.||:....|....:..::::..:...|:|.|||||
Zfish   387 VHQWFGNIVTMDWWDDLWLNEGFASFFEYIGVEEAEHDWGMRDVMLINDVYPVMVDDALLSSHPI 451

  Fly   403 SRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQDNLWESLTQ 467
            ...:...::|:..||.|||.||:|::||:...||.|.||.|.:.||:.|.::||:..:.|::|
Zfish   452 IVDVSSPAEITSVFDAISYNKGASILRMLEDLLGRETFRDGCRRYLKTYLFQNAKTSDFWKAL-- 514

  Fly   468 AAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLL--NTDVSR-----AH 525
             |.::| ||    :..|||:||.|.||||:::|.  |...|||:|.|:||  |.|.|:     .:
Zfish   515 -ADESG-LP----VADIMDTWTKQMGYPVLSLTN--TDTEAKLTQTRFLLDPNADPSQPTTPLGY 571

  Fly   526 KGCWWVPLSYTNQEEKDFNNTAPKEWMECTETGESVPKTIHDLPGPDQWVIFNNQLSAPYKVNYD 590
            |  |.:|:.:...:..:.:....|...|...:|.|     |...|   .:..|......|:||:.
Zfish   572 K--WTIPVKWKALDSTNNSFIFEKGQTEAVISGYS-----HATNG---LIKVNKDHMGFYRVNHH 626

  Fly   591 AQNWKLLIETLNSEDYHSIH-VVNRAQLIDDVLYFAWTGEQDYEIALQVISYLERERELLPWKSA 654
            .|.|..:.|.|..:  |.:: ..:|:..|||:.........||..|..:..||..|.|.:.|...
Zfish   627 DQMWSDIAEQLLMD--HQVYDATDRSSYIDDIFALGRADMVDYGNAFNLTRYLADETEYIVWDRV 689

  Fly   655 FDNLQFVSGILR-QTPNFRFFKNFTRRLITPIYEHLNGINDTVASEEQQDKTILKAIVADWACSF 718
            ..::.:|..:|. .|..:..|:...|..:..|...| |..|    |..|.:.:|:.||...||..
Zfish   690 SASISYVREMLADDTVLYPLFQKLFRGHVQKISREL-GWKD----EGNQTQRLLREIVLGIACQM 749

  Fly   719 EVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKH-GCDEDWDFLWTRYQKANVATE 782
            ...:.:.||...:..|..    ..:..||:.:|.:||...:.: |.:|.|:.::.:|..|.:|.|
Zfish   750 GDQEALDQASDIFNKWIK----GTIGSVPVNLRLLVYRYGMMNSGTEESWEIMFQKYLSATLAQE 810

  Fly   783 KQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIADSEVGFLLAKKYLMDNVDSIS 847
            |..:|..|...:.:.:|.|.||.. .....||.||..::.|.::.|..|.::|..::..|.|.:.
Zfish   811 KDKLLYGLASVKNIHLLHRLLEAT-KNESIIRSQDVFTLVQYVSRSSDGKIMAWDWMTLNWDYLV 874

  Fly   848 KFYHPQSESMSELLPPLSEQIFTQRDYDEFMNFMASSKDQLKDIEQTISQSLETMLINVQWKERN 912
            ..|.....::..|...::....:.....:..:|.|...:.... |....|:|||:..|::|.|||
Zfish   875 NRYTINDRNLGRLPARITTTYSSNLQLWKMEHFFALHPNAGAG-EMPRKQALETVKNNIEWVERN 938

  Fly   913 YE--RF 916
            .:  ||
Zfish   939 KDEIRF 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	169/463 (37%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	77/330 (23%)
enpep	NP_001186660.1	Peptidase_M1	80..473	CDD:279741	147/406 (36%)
		M1_APN_2	89..536	CDD:189008	172/468 (37%)
		ERAP1_C	611..927	CDD:288671	76/328 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.920