DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and Lvrn

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_038953134.1	Gene:	Lvrn / 502160	RGDID:	1562779	Length:	993	Species:	Rattus norvegicus

Alignment Length:	905	Identity:	297/905 - (32%)
Similarity:	440/905 - (48%)	Gaps:	124/905 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 YDHFRLPTALRPQSYDVRILTQLENPDDFH-----FNGTVKIQIEVLQNTHNITLHSKDLTIDDT 81
            :||.|||..|.|..||:.:..:|: ||:..     |.|.|.|.:.....|..:.|||..|.....
  Rat    90 WDHLRLPPWLVPLHYDLELWPRLQ-PDNLSTPSLTFTGRVNITVRCTVATSTLLLHSFFLNYKQV 153

  Fly    82 EI-------TLSQIGGEETTENCITSTAVNPTHDFYILNTCKELLAGQFYELSLPFSAK-LQDQL 138
            |:       |.:...|....||...:..:    .:.:|:..:.|..|..|||:..||.: ||:..
  Rat   154 EVWGPLAPDTRNATVGRVPLENVWFALDM----QYVVLDLGQSLDPGSSYELNFDFSGQVLQEGS 214

  Fly   139 AGYYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMP--- 200
            .|.:.:.|  |..::.|.:..||.||..||..|||||||..||:|.||:.:|..|..|||||
  Rat   215 EGLFLNLY--TDEDQLRALIATQMEPTFARHVFPCFDEPALKATFNITIIHHPGYVALSNMPQLG 277

  Fly   201 ------VNETRPHESIPDYVW--TSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNA 257
                  ||.:|         |  |||..:..|.|||||..:.||.:...| ..|...|.|||.:.
  Rat   278 QSHRIDVNGSR---------WTVTSFHTTPRMPTYLVALVICDFDYVSRT-ERGKEIRVWARKDD 332

  Fly   258 I--DQCDYAAELGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEY 320
            |  ...|:||.....|..:.|:||.|.:||||.|.||:|.|..||||||||:.| :::||...:.
  Rat   333 IADGYLDFAANHTGPVFSFLEDLFNISYPLPKTDIIALPTFVNGAMENWGLMIF-DASLLLELDD 396

  Fly   321 SSQEAKQETANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMS 385
            ...|.:....:|::||:.||||||||||.||.::|||||||:|.........:|:    ...:|.
  Rat   397 DLPEKRAMILSILSHEVGHQWFGNLVTMSWWNNIWLNEGFASYFEVGLTNYFYPK----VPRNMI 457

  Fly   386 NLLTIFRKDSLESSH-----PISRPIE---MTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRT 442
            ..||:.. |.||..|     .:|.|:|   .|.:|:..||..:|:||:.:..|:..||.:..|..
  Rat   458 FFLTVLH-DILEDDHSLESRAVSTPVENFTETREINRLFDIYTYKKGACMAWMLAGFLSQHLFIN 521

  Fly   443 GLKSYLEKYTYKNAEQDNLWESLTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRT 507
            .||||||.::|.|||||:||..:..|..:...:.....:|.||||||.|:|:|||.:    .:.|
  Rat   522 ALKSYLETFSYSNAEQDDLWRHIQMAIDEQSIIHLPATVKRIMDSWTHQSGFPVITL----NAST 582

  Fly   508 AKLSQERYLL---NTDVSRAHKGCWWVPLSYTNQEEKDFNNTAPKEWMECTETGESVPKTIHDLP 569
            ..:.||.:.|   ......:| ..|.||:.:...     ..|.|..|::         |:....|
  Rat   583 GVVKQEPFYLERVENQTLLSH-NTWIVPIFWMKN-----GITQPLVWLD---------KSSMIFP 632

  Fly   570 G------PDQWVIFNNQLSAPYKVNYDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTG 628
            |      ...|||.|..::..|:||||...||.|.:.| .:|..:|.|:||.||:.|....:...
  Rat   633 GMKLSDSDSDWVILNFNVTGYYRVNYDKLGWKKLNQQL-EKDPKAIPVINRLQLVSDAFALSKNN 696

  Fly   629 EQDYEIALQVISYLERERELLPWKSAFDNLQFVSGILRQTPNFRFF----KNFTRRL--ITPIYE 687
            ..:.|.||.:..|:.:|.|:|.|.....|| ....::....|:..:    |.|.:||  |..||.
  Rat   697 YIEIETALDLTKYIAKEDEILVWFEVLVNL-INREVVYDVKNYYLYPLLKKYFLKRLNSIWTIYS 760

  Fly   688 HLNGINDTVASEEQQDKTI----LKAIVADWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPL 748
            .:  |.:.:||  .||..:    ||... :.||...:.||:..:...:|.|.  |:|:  ..:|.
  Rat   761 AI--IRENMAS--LQDNFLSLLPLKKFF-ETACWLGLEDCLQLSRELFRKWM--AHPE--TAIPP 816

  Fly   749 GIRGVVYCTAIKHGCDEDWDFLWTRYQKANVATEKQ----IILDSLGCSQEVWVLQRYLERNFDG 809
            .|..||.|.||..|.::|||||:..|..   .||:|    .::.::|||::...|.|::|  :|.
  Rat   817 QIEKVVLCNAIALGSNKDWDFLFNLYIN---KTEEQEDLFHLVHAMGCSKDPRTLNRFME--YDI 876

  Fly   810 MGDIRKQDSTSVFQAIADSEVGFLLAKKYLMDNVDSISKFYHPQSESMSELLPPLSEQIF 869
            .....:.:.|::.:.:|:||||..:||.:|::|..::.     :|.|:|    ||.:|.|
  Rat   877 TVFPSRFNETNLIEVVAESEVGRYVAKDFLINNWVAVY-----ESPSLS----PLLQQYF 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	175/488 (36%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	95/310 (31%)
Lvrn	XP_038953134.1	M1_APN-Q_like	102..569	CDD:341064	175/489 (36%)
Lvrn	XP_038953134.1	ERAP1_C	643..915	CDD:403137	88/292 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	O	PTHR11533
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920