DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and CG14516

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_651674.3	Gene:	CG14516 / 43444	FlyBaseID:	FBgn0039640	Length:	999	Species:	Drosophila melanogaster

Alignment Length:	918	Identity:	355/918 - (38%)
Similarity:	535/918 - (58%)	Gaps:	41/918 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 AGEGST--YDH-FRLPTALRPQSYDVRILTQLENPDDFHFNGTVKIQIEVLQNTHNITLHSKDLT 77
            ||...|  ||. .|||.::||..|::.|..||..  :|.|.|:|:|:|.||::.:|||:|:::|.
  Fly   100 AGHDDTPKYDRDVRLPHSIRPLKYNITIEPQLSG--NFTFAGSVQIRIRVLEDCYNITMHAEELN 162

  Fly    78 I--DDTEITLSQIGGEETTENC-ITSTAVNPTHDFYILNTCKELLAGQFYELSLPFSAKLQDQLA 139
            |  .|..:...|..||...:.. |....:.....|:::....:||....|.:.|.|...::|.|.
  Fly   163 ISRSDASVHRVQNNGEPEGDGLRIHKQYLVGAKQFFVIELYDKLLKDVEYVVHLRFDGIIEDYLQ 227

  Fly   140 GYYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNET 204
            |:|||||  .|.|||||::.|||:...||.||||||||..||:|.:.:...:..|.:||||:..:
  Fly   228 GFYRSSY--EVHNETRWVASTQFQATDARRAFPCFDEPALKANFTLHIARPRNMTTISNMPIVSS 290

  Fly   205 RPHESIPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAIDQCDYAAELGP 269
            ..|.::|.|||..|.||||||||||||:::||:|    :.:|. |..|||.:||...:||..:||
  Fly   291 NDHATMPSYVWDHFAESLPMSTYLVAYAISDFTH----ISSGN-FAVWARADAIKSAEYALSVGP 350

  Fly   270 KVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANIVA 334
            ::|.:.::.|.:.|||||:|.||:|:|.|||||||||:||.|:.:||.|..::...||..|::|.
  Fly   351 RILTFLQDFFNVTFPLPKIDMIALPEFQAGAMENWGLITFRETAMLYDPGVATANNKQRVASVVG 415

  Fly   335 HELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLESMSNLLTIFRKDSLESS 399
            |||||||||||||..||:|:|||||||:|:..|..:.:.|:|:.|....::.|..:|:.|:|.:|
  Fly   416 HELAHQWFGNLVTPSWWSDIWLNEGFASYMEYLTADAVAPEWKQLDQFVVNELQAVFQLDALSTS 480

  Fly   400 HPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQDNLWES 464
            |.||..:....:|||.||.|||.|||::||||..||....||.||..||::..|.:|.||:||..
  Fly   481 HKISHEVFNPQEISEIFDRISYAKGSTIIRMMAHFLTNPIFRRGLSKYLQEMAYNSATQDDLWHF 545

  Fly   465 LTQAAHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTSRTAKLSQERYLLNTDVSRAHKGCW 529
            ||..|..:|.|....::|.|||:|||||||||:.|:|...|...:|.|.|::............|
  Fly   546 LTVEAKSSGLLDDSRSVKEIMDTWTLQTGYPVVKVSRHPNSDVIRLEQVRFVYTNTTREDESLLW 610

  Fly   530 WVPLSYTNQEEKDFNNTAPKEWMECTETGESVPKT-IHDLPGPD----QWVIFNNQLSAPYKVNY 589
            ::|:::|...|.:|.||.|..||         |:| :::|...:    :|.|||.|.:..|:|||
  Fly   611 YIPITFTTDSELNFANTRPTTWM---------PRTKLYELENRELSLAKWFIFNVQQTGYYRVNY 666

  Fly   590 DAQNWKLLIETL-NSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLERERELLPWKS 653
            |.:||..:.|.| :.:::..|...|||||||||:..|......||.|:.:..||..|...:|||:
  Fly   667 DLENWMAITEHLMDVDNFEDIAPANRAQLIDDVMNLARGSYLSYETAMNLTRYLGHELGHVPWKA 731

  Fly   654 AFDNLQFVSGILRQTPNFRFFKNFTRRLITPIYEHLNGINDTVASEEQQDKTILK---AIVADWA 715
            |..|..|:..:...:.::...||:..:.:..:|:.: |..|   |:::.:..::|   |.:...|
  Fly   732 AISNFIFIDSMFVNSGDYDLLKNYLLKQLKKVYDQV-GFKD---SQDESEDILVKLKRADILSMA 792

  Fly   716 CSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGCDEDWDFLWTRYQKANVA 780
            |.....:|:.:|...:::|....|||..||:...:||||||:||::|.:.:|||.:.|:.|.||.
  Fly   793 CHLGHQECIAEASRHFQNWMQTPNPDSNNPIVPNLRGVVYCSAIQYGTEYEWDFAFERFLKTNVP 857

  Fly   781 TEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIADSEVGFLLAKKYLMDNVDS 845
            .||.::|::||||:|.|:|.|:|.|...|. .|||||...||.|::.:.||..:|..:|.:|...
  Fly   858 GEKDLLLNALGCSKEPWLLYRFLRRGISGQ-HIRKQDLFRVFAAVSTTVVGQNIAFDFLRNNWQE 921

  Fly   846 ISKFYHPQSESMSELLPPLSEQIFTQRDYDEFMNFMASSKDQLKDIEQTISQSLETMLINVQWKE 910
            |..:...|..|:..|....::...::....||.||:   ||...|.::.:.|.:|.:..:|.|..
  Fly   922 IKTYMGSQMSSIHTLFKFATKGFNSKFQLGEFENFV---KDAHWDYDRPVQQIVEHIETSVDWMN 983

  Fly   911 RNYERFTR 918
            :||:...|
  Fly   984 KNYKSIVR 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	202/457 (44%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	111/331 (34%)
CG14516	NP_651674.3	Peptidase_M1	113..505	CDD:279741	176/400 (44%)
		M1_APN_2	121..576	CDD:189008	207/463 (45%)
		ERAP1_C	652..974	CDD:288671	109/329 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	114	1.000	Domainoid score	I6014
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	585	1.000	Inparanoid score	I998
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10752at50557
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	1	1.000	-	-		mtm6446
orthoMCL	1	0.900	-	-		OOG6_100307
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	9	8.970