DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11951 and CG5849

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_650979.1	Gene:	CG5849 / 42556	FlyBaseID:	FBgn0038897	Length:	968	Species:	Drosophila melanogaster

Alignment Length:	956	Identity:	272/956 - (28%)
Similarity:	442/956 - (46%)	Gaps:	150/956 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LILAALGLSFAGE-GSTYDHFRLPTALRPQSYDVRILTQLENPDDFH-----FNGTVKIQIEVLQ 64
            ::|..|||..:|. |......|||.|..|..|      ||....|.|     |:|...|.:.:.|
  Fly     9 VVLVTLGLLVSGSMGERERSLRLPNATYPLFY------QLHISSDIHKGQLLFSGNATIDVAIRQ 67

  Fly    65 NTHNITLHSKDLTIDDTEITLSQI--GGEETTENCITSTAVNPTHDFYILNTCKELLA---GQFY 124
            :|:.|.||:|:||  |.:||:.::  .|.|..:: :|.| ::||....|::..:...|   ||.|
  Fly    68 STNEIVLHAKNLT--DIQITVHRLMAEGSEIVDD-LTHT-LHPTAALLIIHPIENYQAFEEGQQY 128

  Fly   125 ELSLPFSAKLQDQLAGYYRSSYVNTVANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGY 189
            .|.:.::|.:..:.||.|...|.:...|.|.:::.||.||...||.|||:||||:|::|:|.:.:
  Fly   129 RLEILYTAIMASRPAGLYYMDYRDEENNHTVYVAATQCEPTYGRLIFPCYDEPGFKSNFSIKITH 193

  Fly   190 HKKYTGLSNMPVNETRPHESIPDYVWTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWAR 254
            ...::.:|||||.|...|   .|...|||..:.|:||||||:.::||.....|. .|.....:..
  Fly   194 GSSHSAISNMPVKEVLAH---GDLKTTSFHTTPPISTYLVAFVISDFGSISETY-RGITQSIYTS 254

  Fly   255 PNAIDQCDYAAELGPKVLKYYEELFGIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPE 319
            |.:.::...|.:...:.:...|:.||:.:||||:|.:|:......|||||||:|:.:..||.:..
  Fly   255 PTSKEKGQVALKNAVRTVAALEDYFGVSYPLPKLDHVALKKNYGAAMENWGLITYKDVNLLKNIS 319

  Fly   320 YSSQEAKQE--TANIVAHELAHQWFGNLVTMKWWTDLWLNEGFATYVASLCVEDIHPQWRTLQLE 382
            ...|:.|.:  |.|   ||:|||||||||:.:|||..|:|||||||.:.:..:.|:|..:.:.:.
  Fly   320 SDGQKRKLDLITQN---HEIAHQWFGNLVSPEWWTYTWMNEGFATYFSYVITDLIYPNDKMMDMF 381

  Fly   383 SMSNLLTIFRKDSLESSHPISRPIEMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSY 447
            ......:.:..:|....||:|..:|....|...||.|||::|:.||:|.|....::.|..|:..:
  Fly   382 MTHEADSAYSYNSFFDVHPMSHYVEGEKDIMGVFDIISYKRGACVIKMFHHAFRQKLFVRGISHF 446

  Fly   448 LEKYTYKNAEQDNLWESLTQA-------AHKTGSLPKDYNIKTIMDSWTLQTGYPVINVTRDYTS 505
            ||||.|..|.:.||:::|...       :|:    |....|:.||.|||.....|::.|||:|.:
  Fly   447 LEKYRYSVANELNLFDALHSELQDDEYFSHQ----PWASRIREIMLSWTHSEWLPILVVTRNYEN 507

  Fly   506 RTAKLSQERYLLNTDVSRAHKGCWWVPLSYTNQEEKDFNNTAPKEWM----ECTETGESVPKTIH 566
            .|...:|....:..::       ||:|:::...:..:|.:|....:|    :.|.:.|.:  .||
  Fly   508 NTITFTQRSVHMKDEL-------WWIPINFATTQSPNFEDTQVDMFMPPQPQYTVSLEDL--NIH 563

  Fly   567 DLPGPDQWVIFNNQLSAPYKVNYDAQNWKLLIETLNSEDYHS-IHVVNRAQLIDDVLYFAWTGE- 629
             :.|.| |::.|.|.:..|.|.||..|...:...|.:.  || ||.:||..|..|:.......|
  Fly   564 -VSGRD-WIMVNKQHTGFYLVRYDTDNLMAIARQLQTN--HSVIHPINRLGLFRDLGPLIEHNEI 624

  Fly   630 QDYEIALQVISYLERERELLPWKSAFDNLQFVSGILRQTPNFRFFKNFTRRLITPIYEHL---NG 691
            :..|:..:::.|||.|.::|.|....|.::.::..|..|.:...|..|.|||:.|.:..:   .|
  Fly   625 EQVEVVFELLKYLELEEDVLTWNQLQDTIECLTRNLHGTSSQSLFNEFVRRLVGPTFRRVYVEQG 689

  Fly   692 INDTVASEEQQDKTILKAIVADWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYC 756
            :|   .:|:...:.||:.     |||.::.:|    |.:.|....|...|::
  Fly   690 VN---LAEDGMFRGILEI-----ACSADLPEC----LEYTRRLAKEHIIDKI------------- 729

  Fly   757 TAIKHGCDEDWDFLWTRYQKANVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSV 821
             ..|.|.|                  ...|:||:.|.               |:..:..||
  Fly   730 -YFKDGSD------------------YHAIIDSVLCM---------------GVRYLSDQD---- 756

  Fly   822 FQAIADSEVGFLLAKKYLMDNVDSISKFYHP------QSESMSELLPPLSEQIFTQRDYDEFMNF 880
            ||.|.|           :|..:|..|.:|..      .::|...||..| |.:..:..    .:.
  Fly   757 FQRIID-----------MMQEIDRASVYYDDIIYALRCTQSHRHLLYYL-EGLMGENS----THM 805

  Fly   881 MASSKDQLKDIEQTISQSLETMLINVQWKERNYERFTRA--ISKHF 924
            :.|..:.|..:......:|.:..:..|:.||||:...||  ..:||
  Fly   806 VLSEFEDLMYLLYIYKSNLASRPVIWQYIERNYKVLCRAPNFLEHF 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	159/473 (34%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	73/338 (22%)
CG5849	NP_650979.1	Peptidase_M1	30..423	CDD:279741	141/409 (34%)
		M1_APN_2	38..497	CDD:189008	160/479 (33%)
		ERAP1_C	570..>841	CDD:288671	77/351 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I364
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11533
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
	6	6.020