DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11951 and npepps

DIOPT Version :9

Sequence 1:	NP_001350853.2	Gene:	CG11951 / 43463	FlyBaseID:	FBgn0039656	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001157499.1	Gene:	npepps / 407726	ZFINID:	ZDB-GENE-060524-3	Length:	872	Species:	Danio rerio

Alignment Length:	916	Identity:	298/916 - (32%)
Similarity:	452/916 - (49%)	Gaps:	97/916 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RLPTALRPQSYDVRILTQLENPD--DFHFNGTVKIQIEVLQNTHNITLHSKDLTIDDTEITLSQI 88
            ||||.:.|.:|.:|:     .||  ||.|.|.::..:||.|.|:.|.::..|:.|    ||.|.:
Zfish     9 RLPTDVYPVNYGLRL-----KPDLVDFTFEGKLEAAVEVTQGTNQIVMNCADIDI----ITASFV 64

  Fly    89 --GGEETTENCITSTAVNPTHDFYILNTC--KELLAGQFYELSLPFSAKLQDQLAGYYRSSYVNT 149
              ||||     |.:|..|..::...:..|  ..|..|. ..|.:.|..:|.|::.|:|||.|  :
Zfish    65 PDGGEE-----INATGFNYQNEDEKVTLCFPSTLQKGS-GSLKIDFVGELNDKMKGFYRSKY--S 121

  Fly   150 VANETRWISVTQFEPAAARLAFPCFDEPGYKASFAITLGYHKKYTGLSNMPVNETRPHESIPDYV 214
            .:.|.|:.:|||||...||.||||:|||..||:|.|||...|....||||.|.:.:|:......|
Zfish   122 SSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDITLIVPKDRVALSNMNVVDRKPYAEDQSLV 186

  Fly   215 WTSFEESLPMSTYLVAYSLNDFSHKPSTLPNGTLFRTWARPNAIDQCDYAAELGPKVLKYYEELF 279
            ...|..:..|||||||:.:.::....|...:|...|.:......:|..:|.|:..|.|.:|::.|
Zfish   187 EVKFATTPIMSTYLVAFVIGEYDFVESQSSDGVTVRVYTPVGKAEQGKFALEVATKTLPFYKDYF 251

  Fly   280 GIKFPLPKVDQIAVPDFSAGAMENWGLVTFAESTLLYSPEYSSQEAKQETANIVAHELAHQWFGN 344
            .:.:||||:|.||:.||:|||||||||||:.|:.||..|:.|...::|..|.:|.||||||||||
Zfish   252 SVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCASSRQWVALVVGHELAHQWFGN 316

  Fly   345 LVTMKWWTDLWLNEGFATYVASLCVEDIHPQ---WRTLQLESMSNLLTIFRKDSLESSHPISRPI 406
            ||||:|||.||||||||:::..|||:...|:   |........:..|.:   |:|::||||...:
Zfish   317 LVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRALDL---DALDNSHPIEVDV 378

  Fly   407 EMTSQISESFDEISYQKGSSVIRMMHLFLGEEAFRTGLKSYLEKYTYKNAEQDNLWESLTQAAHK 471
            ...|::.|.||.|||.||:|||||:|.::|:|.||.|:.:||.|:.:|||..::|||.|.||:.|
Zfish   379 GHPSEVDEIFDAISYSKGASVIRMLHNYIGDEDFRKGMNAYLLKFQHKNASTEDLWECLEQASGK 443

  Fly   472 TGSLPKDYNIKTIMDSWTLQTGYPVINVTRDY--TSRTAKLSQERYLLNTDVSRAHKGC--WWVP 532
            .        |..:|:|||.|.|:|:|.|.::.  :.|..|:||:::..:.  .|..:.|  |.||
Zfish   444 P--------IAAVMNSWTKQMGFPIIVVDQEQHGSDRVLKISQKKFCASG--PRNDEDCPNWMVP 498

  Fly   533 LSYTNQEEKDFNNTAPKEWMECTETGESVPKTIHDLP---------GPDQWVIFNNQLSAPYKVN 588
            :|....|:.           .||:|     |.:.|.|         .||.|:..|......|::.
Zfish   499 ISICTSEDP-----------SCTKT-----KILLDQPETTVNITNVAPDHWIKINPGTVGFYRIQ 547

  Fly   589 YDAQNWKLLIETLNSEDYHSIHVVNRAQLIDDVLYFAWTGEQDYEIALQVISYLERERELLPWKS 653
            |.:...:.|:..:..   .::..|:|..|.:|:...|..|.......|:|:.....|.....|..
Zfish   548 YSSAMLESLLPGIRD---LTLLPVDRLGLQNDLFSLARAGMISTVEVLKVMEAFVNEPNYTVWSD 609

  Fly   654 AFDNLQFVSGILRQTPNFRFFKNFTRRLITPIYEHLNGINDTVASEEQQDKTILKAIV------A 712
            ...||..:|.:|..|......:.|.|.|.|||...|..  |:...|...| .:|:.:|      |
Zfish   610 LSCNLGVLSSLLSHTDFHEDIQEFIRDLFTPIGMKLGW--DSRTGEGHLD-ALLRGLVLGKLGKA 671

  Fly   713 DWACSFEVSDCVTQALSFYRSWRSEANPDEVNPVPLGIRGVVYCTAIKHGCDEDWDFLWTRYQKA 777
            ....:.|.:         .|.:|......::  :...:|..||.|.:|||.....|.:...:::|
Zfish   672 GHKATLEEA---------RRRFREHVEGKQI--LSADLRSPVYLTVLKHGDSTTLDTMLKLHKQA 725

  Fly   778 NVATEKQIILDSLGCSQEVWVLQRYLERNFDGMGDIRKQDSTSVFQAIA-DSEVGFLLAKKYLMD 841
            ::..||..|...||......::||.|  ||....::|.||:.||...:| .|:.|...|.|::.|
Zfish   726 DMQEEKNRIERVLGAIPAPDLIQRVL--NFALSEEVRPQDTVSVIGGVAGSSKQGRKAAWKFVKD 788

  Fly   842 NVDSISKFYHPQSESMSELLPPLSEQIFTQRDYDEFMNFMASSKDQLKDIEQTISQSLETMLINV 906
            |.:.:...|. ....:|.|:....:.....:...|..:|..|  ......|:|:.|..|.:|:|.
Zfish   789 NWEELHNRYQ-GGFLISRLIKLTVDGFAIDKMAAEVKSFFES--HHAPAAERTVQQCCENILLNA 850

  Fly   907 QWKERN 912
            .|.:|:
Zfish   851 AWLKRD 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11951	NP_001350853.2	M1_APN-Q_like	35..490	CDD:341064	187/463 (40%)
CG11951	NP_001350853.2	ERAP1_C	574..902	CDD:338125	77/334 (23%)
npepps	NP_001157499.1	Peptidase_M1	9..396	CDD:279741	162/406 (40%)
		M1_APN_2	17..459	CDD:189008	190/469 (41%)
		ERAP1_C	534..845	CDD:288671	75/332 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D110058at2759
OrthoFinder	1	1.000	-	-		FOG0000044
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X67
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920